Multi-phase packed-bed microreactor with active carbon catalyst (Courtesy of M. Losey, MIT) |
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Multi-phase packed-bed microreactor with active carbon catalyst (Courtesy of M. Losey, MIT) |
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Projects : Microfluidic Chemical Systems
Paper presentation and Review Guidelines -also available in PDF format
Each group of 4-3 students will give a presentation and prepare a report of a paper selected from the recent microfluidics literature. The format of the presentation and the report are summarized below. The presentation and report will be graded on the basis of the following items:
1. Summarize the motivation for the microfluidic study and the application.
Place the work in context by reviewing similar work in the field.
2. Describe the microfluidic study - including fabrication sequence
and microfluidic experiments on a particular application.
3. Give an analysis of relevant chemical engineering concepts used
in the paper.
4. Evaluate whether or not the use of microfluidics enables investigations
that could not have been done with conventional macroscopic approaches.
5. Consider improvements to the microfluidic device or study.
Develop a better design.
6. Evaluate the overall contributions of the work by comparing to other
work and macroscopic approaches.
Presentations
Each presentation will be 12 minutes with 3 minutes for questions.
The presentation should address the items above and be prepared on overheads.
Because of the short time constraint, select one (or at most two) presenters
for the group.
The presentations will be scheduled for the last 2-3 days of
the module.
Reports
The report should follow the outline above and address all items.
The report should be typed (for readability: 1 1/2 or double spaced, 1"
margins on all sides, 12 pt font) and not exceed 6 pages excluding graphics,
appendix, and literature cited. Include details of the chemical engineering
analysis in the Appendix. If any design calculations are made in
point 5, place them in the Appendix.
Reports are due in 66-560 March 9 by 3 pm.
Microfluidic Projects:
1. Use of microreactors to perform difficult/hazardous liquid phase reactions.
K. Jaehnisch, M. Baerns, V. Hessel, W. Ehrfeld, V. Haverkamp, H. Loewe, Ch. Wille, A. Guber," Direct fluorination of toluene using elemental fluorinein gas/liquid microreactors," Journal of Fluorine Chemistry 105, 117-128 (2000).
2. Use of microreactors to perform difficult/hazardous gas phase reactions
3. Soft lithography as a method for making integrated microfluidic systems for biological applications.
Marc A. Unger, Hou-Pu Chou, Todd Thorsen, Axel Scherer, and Stephen R. Quake," Monolithic Microfabricated Valves and Pumps by Multilayer Soft Lithography," Science 288, 113-116 (2000).
4. Microreactors incorporating solid particles for reactions and separations.
Richard D. Oleschuk, Loranelle L. Shultz-Lockyear, Yuebin Ning, and D. Jed Harrison, "Trapping of Bead-Based Reagents within Microfluidic Systems: On-Chip Solid-PhaseExtraction and Electrochromatography," Anal. Chem. 72, 585-590 (2000).
5. Hydrogels as materials for making integrated microfluidic systems for biological applications.
David J. Beebe, Jeffrey S. Moore, Qing Yu, Robin H. Liu, Mary L. Kraft, Byung-Ho Jo, and Chelladurai Devadoss, "Microfluidic tectonics: A comprehensive construction platform for microfluidic systems," Proc. Natl. Acad. Sci. USA, 97, 13488?13493 (2000).
6. Microreactors with immobilized enzymes
7. Using microreactors to create emulsions and controlling reactions in dispersed liquid phases.
Verena Haverkamp, Wolfgang Ehrfeld, Klaus Gebauer, Volker Hessel, Holger Löwe, Thomas Richter, and Christian Wille, "The potential of micromixers for contacting of disperse liquid phases," Fresenius J Anal Chem 364 617?624 (1999).
8. Find your own microreactor papers and
propose a project.
