Course Description:

Emphasizes methods and logic used to analyze eukaryotic cells in diverse systems (e.g., yeast, fly, worm, mouse, human; development, neurons).

Subject combines lectures and in-depth roundtable discussions of literature readings with active participation of faculty experts. Focuses on membranes, organelles, the cell surface, cytoskeleton and extracellular matrix.

Topics include:

membrane protein structure, cell surface receptors and transporters;

signal transduction pathways;

membrane trafficking/sorting/secretion;

adhesion and its effects on organization, migration and polarity of cells;

regulation of the cell cycle;

integration of cells into tissues and organs.

Ranges from basic studies to applications to human disease, while emphasizing critical analysis of experimental approaches. Limited enrollment.