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Updated: August 29, 2007
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| Month |
Monday - Lecture |
Wednesday - Lecture |
Friday - Recitation |
| September |
5 Introduction to the problem |
7 Side-chain review and Sulphur redox chemistry | |
|
10 The Anfinsen experiments |
12 Globular protein structure & protein interiors |
14 Using the Protein Databank (PDB) | |
|
17 Helix-helix packing in globular proteins |
19 Beta-sheets and beta-sheet packing |
21 Experimental techniques: circular dichroism | |
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|
24 Student Holiday-- no classes |
26 Thermal denaturation; coiled-coils and refolding of Tropomyosin |
28 Fluorescence spectroscopy |
| October |
1 S-peptide helical folding |
3 Detecting partially folded intermediates |
5 Prolyl isomerization |
|
8 - Columbus Day - No Classes |
10 Cytochrome c refolding pathway |
12 2-D MNR techniques | |
| 15 Collagen structure and folding in vitro |
17 Procollagen folding in vivo |
19 Protein calorimetry: BPTI S-S discussion | |
| 22 Protein misfolding and aggregation |
24 Ribosome channel, nascent chains and trigger factor |
26 Graded problem set due | |
| Oct/November |
29 Scaffolding proteins in viral shell assembly |
31Amyloid fiber formation in neuro degenerative disease |
2 MID-TERM |
| 5 Chaperonin assisted folding |
7 Eukarotic chaperonins |
9 Research paper topics and choices |
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| 12 Veteran's Day - no classes |
14 Membrane protein (rhodopsin) folding and assembly |
16 Prion diseases |
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| 19 Social
issues in Biomedical research |
21 Thanksgiving
- No Class |
23 Thanksgiving - No Recitation | |
| 26 Student
presentations |
28 Student
presentations |
30 Student
presentations |
|
| December |
3 Student
presentations |
5 Student
presentations |
7 Student
presentations |
| 10 Student
presentations |
12 Student
presentations |
14 - Final papers DUE | |
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