Function

1. Filaments in the cycloskeleton:

  • Actin, threadmilling
  • Microtubules, dynamic instability
  • Molecular motors, ratchet models, asymmetric hopping models

2. Cooperativity:

  • Hemoglobin: evolution, polymorphism, folding and fibrilation, function, regulation, ...
  • kinetic proof reading
4. Protein-Nucleic acid composites:
  • Electrostatic interactions
  • Specific and non-specific binding of factors to DNA regulatory elements
  • Berg-von Hippel, wight matrices (profiles), information content

4. Cells of the adaptive immune system:

  • Affinity maturation of B cells
  • Thymic selection of  T cells

Monday 3/28
L17  (MK) Microtubules

Wednesday 3/30
L18 (MK) Motors

Friday April 1
L19 (LM via zoom)  Cooperativity

Monday April 4
L20 (LM via zoom)  protein-DNA energetics

Wednesday April 6
L21 (LM via zoom)  protein-DNA kinetics

Monday  April 11
L22 (AKC) Thymic selection

Wednesday April 13
L23  (AKC) Affinity maturation

lec1- function