Function

1. Filaments in the cycloskeleton:

  • Actin, threadmilling
  • Microtubules, dynamic instability
  • Molecular motors, ratchet models, asymmetric hopping models

2. Cooperativity:

  • Hemoglobin: evolution, polymorphism, folding and fibrilation, function, regulation, ...
  • kinetic proof reading
4. Protein-Nucleic acid composites:
  • Electrostatic interactions
  • Specific and non-specific binding of factors to DNA regulatory elements
  • Berg-von Hippel, wight matrices (profiles), information content

4. Cells of the adaptive immune system:

  • Affinity maturation of B cells
  • Thymic selection of  T cells

Tuesday October 22
L13:  (MK) Microtubules

Thursday  October 24
L14: (MK) Molecular motors

Tuesday October 29
L15:  (MK)  Adaptive immunity, Thymic selection

Thursday  October  31
L16: (MK)  Adaptive immunity, Affinity maturation

Tuesday November 5
L17: (LM)  Cooperativity, Hemoglobin

Thursday  November  7
L18: (LM)  Protein-DNA energetics

Tuesday November 12
L19: (LM) Protein-DNA kinetics

lec1- function