Function

1. Filaments in the cycloskeleton:

• Actin, threadmilling
• Microtubules, dynamic instability
• Molecular motors, ratchet models, asymmetric hopping models

2. Cooperativity:

• Hemoglobin: evolution, polymorphism, folding and fibrilation, function, regulation, ...
• kinetic proof reading

4. Protein-Nucleic acid composites:

• Electrostatic interactions
• Specific and non-specific binding of factors to DNA regulatory elements
• Berg-von Hippel, wight matrices (profiles), information content

4. Cells of the adaptive immune system:

• Affinity maturation of B cells
• Thymic selection of  T cells

L13:  (MK) Microtubules

L14: (MK) Molecular motors

L15:  (MK)  Adaptive immunity, Thymic selection

L16: (MK)  Adaptive immunity, Affinity maturation

L17: (LM)  Cooperativity, Hemoglobin

L18: (LM)  Protein-DNA energetics

L19: (LM) Protein-DNA kinetics