Sequence information & evolution

1. Elements of population Genetics:

  • Mutations, Finess, selection
  • Fixation
2. Mathematical tools:
  • Transition probability matrix; approach to steady state
  • Master equation
  • Forward and backward Kolmogorov equations
  • Mean first passage time

3. Population Genetics of Cancer

4. Immune system

  • Fitness landscape for pathogens

Monday  January 31
L1: (MK) Introduction and evolving probabilities

Wednesday February 2
L2: (LM in person) Elements of population genetics

Friday  February 4
L3:   (LM in person) Fitness landscapes

Monday   February 7
L4: (LM in person) Population genetics of cancer

Wednesday  February 9
L5: (MK) Forward Kolmogorov equation

Friday February 11
L6:  (MK) Backward Kolmogorov equation

Monday February 14 
L7: (AKC) viral fitness landscapes I

Wednesday February 16 
L8: (AKC) viral fitness landscapes II


lec1- Sequence