Macromolecular Structure

1. Introduction to polymers:

  • Entropy and elasticity
  • Interactions and the coil-globule transition
  • Simple lattice models of protein folding
  • Random Energy Model for freezing
2. Protein folding:
  • Role of hydrophobicity and other interactions
  • Secondary structure elements:    alpha-helices & beta-sheets
  • Classification of protein structures, and their evolution
  • Dynamics of fast folding
3. DNA and RNA:
  • Watson-Crick pairing
  • Energy/entropy considerations, and DNA melting
  • RNA secondary structures
  • Hartree equation for obtaining secondary structures without pseudo-knots

L6: (MK) Phases of polymers

L7: (MK) Compact polymers and REM

L8:  (LM) Interactions in biology

L9: (LM)  Protein folding energetics

L10: (LM)  Protein folding kinetics

L11: (MK)  DNA

L12: (MK) RNA


lec1- Structure