8.592 - HST.452J (Spring 2024)

Statistical Physics in Biology

Lecture 12


RNA secondary structure

  1. Structure and function of RNA   (wikipedia)
  2. The 'RNA world' hypothesis
  3. Structural levels:
  4. Representations without psuedoknots
  5. Algorithms for finding optimal secondary structure: Nussinov (article), unafold web-server (M. Zuker)
  6. Recursive calculation of partition function
  7. RNA folding and Matrix Field Theory (McGenus)
  8. Counting secondary structures. [Chandrasekhar, Rev. Mod. 15, 1 (1943)]
  9. Thermal denaturation of RNA
  10. The melting of a hairpin

Lecture notes



8.592  lecture- last update    10/17/2024    by M. Kardar