8.592 - HST.452J (Spring 2025)

Statistical Physics in Biology

Lecture 14

Protein-DNA energetics

1. Regulation of genes by protein-DNA interactions  (slides)
• Lac repressor
• CRP activation
• Recruitment of polymerase
2. Structure of protein-DNA complexes 
• Lac repressor
• Specificity
• Bonds
• DNA bending, non-direct readout

(Lecture note from 4/1/2022)

(Lecture note from 2024)

• Mirny lecture notes on protein-DNA interactions from 2018
• Protein-DNA energetics