8.592 - HST.452J (Spring 2022)

Statistical Physics in Biology

Lecture 20

(zoom link: https://mit.zoom.us/j/9399)

Recording from the zoom session

Protein-DNA Interaction (Kinetics)

1. Specificity
• length of transcription factor binding sites
• bacteria vs. human
2. Kinetics of binding (2009 lecture notes)

• Reaction Kinetics
• Debye-Smoluchowski theory and equation
• Estimated and observed rates
• Berg-von Hippel theory of facilitated diffusion

(Lecture note from 4/4/2022)

• Notes on protein-DNA interaction energetics
• Slides on Facilitated Diffusion
• Lecture note from 4/15/2020