8.592 - HST.452J (Spring 2022)
Statistical Physics in Biology
Lecture 9
(Please note that lecture is being recorded)
8.592 in 4-265 on 02/23/2022 at 2:30PM
Electostatic Interactions
Ionic solutions:
Why do electrolytes dissociate (ionize) in water?
The bare Coulomb interaction and the Bjerrum length
Acids, bases, and salts
The importance of Coulomb repulsion in biological systems
Macroions, counterions, salt ions
Restricted partition function
Statistical treatments of ionic solutions:
`Mean-field' potential and charge density via the self-consistent
Poisson-Boltzmann equation
Screening in salt solutions
Linearized Poisson-Boltzman
Debye-Hückel theory
Dissociation from a charged membrane
Solution of the 1d equation
The Gouy-Chapman layer
Interaction between charged parallel plates
Importance of fluctuations;
like charges can attract
(
Lecture Notes
)
Some related links
DNA-Inspired Electrostatics
, Gelbart et al, Physics Today
53
, 38 (2000).
Electrostatics in DNA-peptide complexes
; from a course on Principles of Protein Structure
Ten years of tension: single-molecule DNA mechanic
; Bustamante, et al, Nature
421
, 423 (2003).
On
DNA elasticity
;
Philip Nelson
at UPenn
The residual potential
;
Bruce Tidor
at MIT
8.592
lec9- last update 2/21/22 by M. Kardar