8.592 - HST.452J (Spring
2024)
Statistical Physics
in Biology
Lecture 9
Population Genetics of Cancer
- Haldane's equation for fixation of
- Near neutral mutations
- Weakly advantageous/deleterious mutations
- Hallmarks of cancer:
- Driver mutations: oncogenes and tumor suppressors
- High mutation rates
- Passenger mutations
- Model of tumor progression
- Target spaces for drivers/passengers
- Population size from logistic map
- Punctuated growth due to mutations
Some useful links:
Copy-number changed in cancer https://portals.broadinstitute.org/tcga/home
Somatic mutation in cancer and normal cells https://pubmed.ncbi.nlm.nih.gov/26404825/
(Slides from Mirny)
(Mirny Lecture Notes)
(Kardar Lecture Notes, slightly updated)
8.592 lec8- last update 10/7/24 by
M. Kardar