Home work set 4 (sample figures)
Examination of the kinetic properties of AMPA and NMDA receptors
The kinetic steps of glutamate receptor activation following the release of transmitters can be summarized in the following general scheme. The set of equations can be used to simulate the process of glutamate receptor activation.
For NMDA receptor
For AMPA receptor
and R the glutamate receptor, A the concentration of transmitter, AR the receptor with single transmitter binding, A2R the receptor with two transmitter binding, and A2R* the receptor in open channel configuration. Therefore, the probability of channel opening after transmitter release Po will be determined by A2R*.
The kinetic rate constants for AMPA receptors are
The kinetic rate constants for NMDA receptors are
The concentration of glutamate in the synaptic cleft can be imitated by
where Amax is the peak concentration of transmitters. During the process of synaptic transmission, Amax can vary from 100 mM up to 3000 mM.
Solve above equations numerically using MATLAB and answer the following questions.