In my NIH Project (5R01-GM48358-07) I am involved in developing new ways
to treat the thermodynamics of systems of biochemical reactions and in
producing new types of tables of thermodynamic properties of biochemical
reactants, including proteins. Mathematica programs and data bases have
been put on the web so that the apparent equilibrium constants and other
thermodynamic properties of biochemical reactions can be calculated by
simply typing in the reactions. It is important to understand that if
the standard transformed Gibbs energy of a reactant or reaction can be
expressed as a function of its natural variables (for example temperature
and pH), all the other standard thermodynamic properties can be calculated
by taking partial derivatives. These are calculations that have been facilitated
by the development of mathematical programs for personal computers.
Alberty, R. A. Effect of Temperature on Standard Transformed Gibbs Energies of Formation of Reactants at Specified pH and Ionic Strength and Apparent Equilibrium Constants of Biochemical Reactions, J. Phys. Chem. B, 105, 7865-7870 (2001).
Alberty, R. A. Systems of Biochemical Reactions from the Point of View of a Semigrand Partition Function, Biophys. Chem., 93, 1-10 (2001).
Alberty, R. A. Thermodynamics of Systems of Biochemical Reaction Systems, J. Theoret. Biology, 215, 491-501 (2002).
Alberty, R. A. Inverse Legendre Transform in Biochemical Thermodynamics: Applied to the Last Five Reactions of Glycolysis, J. Phys. Chem., B 106, 6594-6599 (2002).
Alberty, R. A. BasicBiochemData2, (2002)
Alberty, R. A. Standard Transformed Gibbs Energies of Coenzyme Derivatives as Functions of pH and Ionic Strength, Biophys. Chem., in press.
Alberty, R. A. Thermodynamics of Biochemical Reactions, Wiley (2003).
Alberty, R. A. Effect of Temperature on the Standard Transformed Thermodynamic Properties of Biochemical Reactions with Emphasis on the Maxwell Equations, J. Phys. Chem., in press.
Alberty, R. A. Fundamental Equation of Thermodynamics for Protein-Ligand
Binding, Biophys. Chem., in press.
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