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Project 4.1.3: Rugged, High Sensitivity, Integrated, Photonic Chemical Sensing
Project 4.1.3 seeks to endow surfaces with the ability
to inactivate human viruses, in particular pathogenic strains
of influenza virus. The proposed work builds on the previous
4 years of ISN research (ISN-1 Project 3.1) focused on
creating novel, non-leaching, nano-inspired, bactericidal
and also fungicidal surfaces. Recently, in ISN-sponsored
studies, Klibanov discovered the efficacy of N-dodecyl,N-methyl-polyethylenimine
coatings for reducing the viral titer of the H1N1 (WSN/33)
strain of influenza. Project 4.1.3 proposes to expand,
investigate, rationalize, exploit, and thoroughly explore
these initial findings. Hammond will derivatize hyperbranched
polyelectrolytes tailor-made for virucidal applications
and investigate their incorporation onto surfaces using
layer-by-layer techniques. Chen (new ISN PI) will supervise
all virucidal and toxicity testing and provide a mechanistic
examination of virucidal action. The nano-inspired hydrophobic
virucidal polymers dissolved in organic solvents would
be “painted” (e.g., sprayed or brushed) onto
a variety of objects and surfaces of military relevance,
including weapons, uniforms, interior walls, barrack furniture
and fixtures, and air ducts and filters. These coatings
should drastically reduce the spread of influenza (and
possibly other viral) infections. Note that even mild flu
adversely affects the battle readiness and performance
of the Soldier and other military, security, and support
personnel.
Project 4.1.3 Researchers
Prof. Marc Baldo, Department of Electrical Engineering and Computer Science
Prof. Vladimir Bulovic, Department of Chemical Engineering
Prof. Timothy Swager,
Department of Chemistry
Prof. Michael Watts,
Department of Chemistry
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