Publications
Y. Boucher, M. Labbate, J.E. Koenig and H.W. Stokes (2007) The Integron: an adaptable and mobilizable platform that promotes genetic diversity in bacteria. Trends in Microbiology (in press).
A. Robinson, A.P. Guilfoyle, S.J. Harrop, Y. Boucher, H.W. Stokes, P.M.G. Curmi and B.C. Mabbutt (2007) A putative house-cleaning enzyme encoded within an integron array: 1.8 Å crystal structure defines a new MazG subtype. Molecular Microbiology (in press).
M. Labbate, Y. Boucher, M. J. Joss, C. Michael and H. W. Stokes (2007) Use of chromosomal integron arrays as a phylogenetic typing system for Vibrio cholerae pandemic strains. Microbiology (in press).
R.J. Case, Y. Boucher, I. Dahllöf, C. Holmström, W. F. Doolittle, S. Kjelleberg (2007) Comparing the 16S rRNA and rpoB genes as molecular markers for microbial ecology. Applied and Environmental Microbiology 73(1):278-288.
J. Bucknam, Y. Boucher and E. Bapteste (2006) Refuting Phylogenetic Relationships. Biology Direct 1:26.
H.W. Stokes, C.L. Nesbo, M. Holley, M.I. Bahl, M.R. Gillings, Y. Boucher (2006) Class 1 integrons potentially predating the association with tn402-like transposition genes are present in a sediment microbial community. Journal of Bacteriology 188(16):5722-30.
Y. Boucher, C.L. Nesbø, M.J. Joss, A. Robinson, B.C. Mabbutt, M.R. Gillings, W.F. Doolittle and H.W. Stokes (2005) Recovery and evolutionary analysis of complete integron gene cassette arrays from Vibrio. BMC evolutionary biology 6(1):3
J.W. Liu, Y. Boucher, H.W. Stokes and D.L. Ollis (2005) Improving protein solubility: the use of Escherichia coli dihydrofolate reductase (DHFR) gene as a fusion reporter. Protein Expression and Purification 46(2):173-178.
C.L. Nesbø, Y. Boucher, M. Dlutek and W.F. Doolittle (2005) Estimating Levels of Lateral Gene Transfer in Environmental Fosmid Clones. Environmental Microbiology 7(12):2011-2026.
U. Gophna, J.R. Thompson, Y. Boucher and W.F. Doolittle (2005) Complex histories of genes encoding 3-hydroxy-3-methylglutaryl-Coenzyme A reductase. Molecular Biology and Evolution 23(1):168-178.
E. Bapteste, C. Brochier and Y. Boucher (2005) Higher-level Classification of the Archaea: evolution of Methanogenesis and Methanogens. Archaea 1:353-363.
M. O’Malley and Y. Boucher (2005) Paradigm shift in evolutionary microbiology. Studies in the History and Philosophy of Biological and Biomedical Sciences 36(1):183-208.
E. Bapteste, Y. Boucher and W. Ford Doolittle (2004) Phylogenetic reconstruction and lateral gene transfer. Trends in Microbiology 12(9):406-411.
Y. Boucher, C.J. Douady, A.K. Sharma, M. Kamekura and W.F. Doolittle (2004) Frequent intraspecific heterogeneity of rDNA genes among extremely halophilic archaea. Journal of Bacteriology 186(12):3980-3990.
Y. Boucher, M. Kamekura and W.F. Doolittle (2004) Origin and evolution of isoprenoid lipid biosynthesis in archaea. Molecular Microbiology 52(2):515-527.
C.J. Douady, F. Delsuc, Y. Boucher, W.F. Doolittle and E.J.P. Douzery (2003) Comparison of Bayesian and maximum likelihood bootstrap measures of phylogenetic reliability. Molecular Biology and Evolution 20(2):248-254.
C. Blouin, Y. Boucher, A.J. Roger (2003) Inferring functional constraints and divergence in protein families using 3D mapping of phylogenetic information. Nucleic Acids Research 31(2):790-7.
Y. Boucher and W.F. Doolittle (2002) Something new under the
sea. Nature 417(6884):27-28.
Y. Boucher, H. Huber, S. L’Haridon, K.O. Stetter and W.F. Doolittle (2001) Bacterial Origin for the Isoprenoid Biosynthesis Enzyme HMG-CoA Reductase of the Archaeal Orders Thermoplasmatales and Archaeoglobales. Molecular Biology and Evolution 18(7):1378-88.
C.L. Nesbø, Y. Boucher and W. F. Doolittle. (2001) Comparative Genomics of Four Archaea: Is there a Core of Non-Transferable Proteins? Journal of Molecular Evolution 53(4-5):340-50.
Y. Boucher and W.F. Doolittle (2000) The Role of Lateral Gene Transfer in the Evolution of Isoprenoid Biosynthesis Pathways. Molecular Microbiology 37(4): 703-716.
Research Interests
‣General: Microbial evolution, Molecular evolution, Molecular phylogenetics, Bioinformatics, Environmental microbiology.
‣Specific: Mobile genetic elements, Evolution of the ribosome, Evolution of isoprenoid biosynthesis pathways, Lateral gene transfer in prokaryotes, Microbiology of halophilic archaea.

Education
2003 - Ph.D., Dalhousie University, Molecular Evolution
1998 - B.Sc., Université Laval, Biochemistry
Yan Boucher

Postdoctoral Associate
Department of Civil and Environmental Engineering
MIT 48-336A
77 Massachusetts Avenue
Cambridge, MA 02139
Phone: (617) 258-7407 Fax: (617) 253-7475
Email: yboucher(at)mit.edu