Jason Locasale Graduate Student Department of Biological Engineering Room E19-534 Phone: 617-252-1744 Fax: 617-253-2272 E-mail: locasale@mit.edu Using theoretical and computational frameworks that are rooted in statistical physics, I study models that probe the mechanisms underlying complex dynamical behavior that emerges in the course of signal transduction with particular attention to T cells. Current and past projects involve: 1.) the role of scaffold proteins in MAPK signaling with particular attention to the KSR system in mammalian cells 2.) signaling dynamics in the immunological synapse 3.) investigations into the nature of memory effects in T cell activation.