My main research interests are complex trait genomics, regulatory
genomics, and epigenomics. I work on algorithms and statistical methods
to elucidate the genetic basis of human disease.
My current work develops efficient Bayesian methods to understand the
architecture of common diseases: how many causal genetic variants are
there, where in the genome do they reside, and how should we design
studies to more rapidly discover them in the population?
Previously, I developed methods to query how genetic variation which
does not alter protein-coding sequences contributes to human disease.
We integrate epigenomic information from
Epigenomics consortia to identify cell-type–specific
enhancers enriched for disease associated variants, and additional
information about the transcriptional regulatory network to dissect
their mechanistic role in psychiatric, metabolic, and autoimmune
- Yongjin Park*, Abhishek K. Sarkar*, et al. “Multi-tissue polygenic models for transcriptome-wide association studies.” BioRxiv. (2017) *Equal contribution
- Kunal Bhutani*, Abhishek Sarkar*, et al. “Modeling prediction error improves power of transcriptome-wide association studies.” BioRxiv. (2017) *Equal contribution
- Felix Day, …, Abhishek K. Sarkar, et al. “Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility.” BioRxiv. (2016) Author 9/215 (accepted)
- Abhishek K. Sarkar, Lucas D. Ward, Manolis Kellis. “Functional enrichments of disease variants across thousands of independent loci in eight diseases.” BioRxiv. (2016) (in revision)
- Yaping Liu, Abhishek Sarkar, Manolis Kellis. “Evidence of a recombination rate valley in human regulatory domains.” BioRxiv. (2016) (in revision)
- Abhishek Sarkar, Yongjin Park, Manolis Kellis. “Dissecting the non-infinitesimal architecture of complex traits using group spike-and-slab priors” (contributed talk). Workshop on Machine Learning in Computational Biology, Thirtieth Annual Conference on Neural Information Processing Systems, Barcelona, Spain. 2016.
- Abhishek Sarkar, Yongjin Park, Manolis Kellis. “Dissecting the non-infinitesimal architecture of complex traits” (poster). 68th meeting of the American Society of Human Genetics, Vancouver, Canada. 2016.
- Abhishek Sarkar, Luke Ward, Manolis Kellis. “Functional enrichments of disease variants across thousands of independent loci in eight diseases.” (talk). Leena Peltonen School of Human Genomics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK. 2016.