Financial support for research in the Center comes from many sources. The core of this support, which provides much of the funds for administration, partial faculty salary support, and central research facilities (i.e. glass washing facility, specialized laboratories and partial support for new faculty), is a Center Core grant from the National Cancer Institute. This grant was renewed this year and its current term extends to April 30, 2000. In addition to the core grant, the Center's faculty have a total of 44 fully funded projects (plus over half a million dollars of competitive support in fellowships for postgraduate studies). This support comes largely from the National Institutes of Health and the Howard Hughes Medical Institute and from a variety of foundations supporting research in particular disease areas (American Cancer Society, Hereditary Disease Foundation, Muscular Dystrophy Association, National Neurofibromatosis Foundation, etc.). This latter type of support is particularly valuable for starting projects which later mature into federally funded grants. The Center's success in attracting grant support is a reflection of the excellence of the research and educational activities of its faculty members. The FY95 research volume was approximately $11 million, which does not include $2.9 million in support from the Howard Hughes Medical Institute.
Several groups in the Center study the identity of oncogenes. This work includes the recent identification of the Wilm's tumor oncogene as well as basic molecular studies on other oncogenes and tumor suppressor genes that regulate gene expression controlling the cell cycle and tumor growth. Another focus is on the biochemical mechanisms controlling RNA transcription and splicing, including studies of genes of the AIDS virus, HIV.
The immunologists in the Center study the development of cytotoxic and helper T lymphocytes, their antigen-specific receptors, and the molecular mechanisms of antigen presentation. Since the immune response to tumors is poorly understood, these basic studies are crucial to a more profound analysis of tumor rejection. Immune cells can destroy cancer cells and it may be possible to stimulate this process.
The cell biologists study cell surface proteins involved in cellular adhesion and migration, as well as cytoskeletal proteins involved in cell motility and shape. Alterations in cell adhesion proteins contribute to the malignant phenotype of tumor cells. These proteins as well as cytoskeletal proteins are important targets for antitumor drugs, and deeper understanding of their structure and function should contribute to better therapeutic agents.
Since the cellular processes of development and cancer have much in common, useful insights into the behavior of tumor cells can be obtained from studies of normal embryos; several projects in the Center focus on developmental processes. Recent advances in the generation of transgenic mice and mice with mutations in targeted genes are being exploited to investigate the roles of a variety of proteins important in tumorigenesis, including oncogene proteins, tumor suppressor genes, cell adhesion receptors, T-cell receptors and protein kinases.
Major research advances in the past year include:
In addition to its strengths in basic research, the CCR performs an important role in training future researchers in biomedical science, including undergraduate and graduate students, postdoctoral and clinical fellows. The faculty of the Center fulfill critical roles in the educational programs of the Department of Biology. Our colleague, Dr. Phillip Sharp, has served as Head of the Department for the past four years. Dr. Frank Solomon serves as Chairman of the Department's Graduate Program. Extensive collaborations exist with medical schools, hospitals and the biotechnology/pharmaceutical industries. Thus, the research in the CCR has a major impact both on the fundamental understanding of cancer and on translation to and from the clinical arena.
A major strength of the Center remains its attractiveness as an environment for the training of young scientists. The Center has 61 graduate and undergraduate students and 91 postdoctoral fellows/associates. The Center also benefited from a number of international faculty-rank visitors during the past year.
Major honors received by faculty of the Center during this past year were:
Professor Susumu Tonegawa was made an Honorary Member of the Polish Academy of Sciences and will receive the Golden Medal Medicus Magnus in Warsaw in 1996.
Richard O. Hynes
MIT Reports to the President 1994-95