Arjun (AJ)
Bhutkar is a research scientist at the Koch Institute for Integrative Cancer
Research at MIT. His focus is in the area of computational biology /
bioinformatics related to cancer genomics.
Prior to this,
he held a joint research appointment at the Department of Molecular and
Cellular Biology at Harvard University and BioMolecular Engineering Research
Center at Boston University.
Previously, AJ worked for over 11
years in the semiconductor industry including as Engineering Department Manager
at Intel Corporation and VP of Business Development at Liberato Technologies.
He holds a PhD in Bioinformatics from
Boston University, an SM in Engineering and Management from MIT, an MS in Computer Science from Texas
A&M University, and a BE in Computer Engineering from the University of
Poona, India.
Contact: arjun”at”mit.edu
Publications:
Genomics:
Proliferation and Tumorigenesis of a Murine Sarcoma Cell Line in the Absence of Dicer (Arvind Ravi, Allan M. Gurtan, Madhu S. Kumar, Arjun Bhutkar, Christine Chin, Victoria Lu, Jacqueline A. Lees, Tyler Jacks, Phillip A. Sharp
), Cancer Cell, 2012 [Online]
In vivo structure-function analysis of human Dicer reveals directional processing of precursor miRNAs (Allan M. Gurtan, Victoria Lu, Arjun Bhutkar, and Phillip A. Sharp
), RNA, 2012 [Online]
Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop (Trudy G. Oliver, Etienne Meylan, Gregory P. Chang, Wen Xue, James R. Burke, Timothy J. Humpton, Diana Hubbard, Arjun Bhutkar, and Tyler Jacks
), Molecular Cell, 2011 [Online]
Poly(ADP-Ribose) Regulates Stress Responses and MicroRNA Activity in the Cytoplasm (Leung AK,
Vyas S, Rood JE, Bhutkar A, Sharp PA, Chang P), Molecular Cell, 2011 [Online]
Genome-wide
identification of Ago2 binding sites from mouse embryonic stem cells with and
without mature microRNAs (Leung AK,
Young AG, Bhutkar A, Zheng GX, Bosson AD, Nielsen CB, Sharp PA), Nature Structural
& Molecular Biology, 2011 [PDF]
Chronic
cisplatin treatment promotes enhanced damage repair and tumor progression in a
mouse model of lung cancer (Oliver TG, Mercer KL, et al.), Genes Dev.,24(8):
837 852, 2010 [PDF]
Chromosomal
rearrangement inferred from comparisons of twelve Drosophila genomes (Arjun
Bhutkar, Stephen W Schaeffer, Susan M Russo, Mu Xu, Temple F. Smith, William M.
Gelbart), Genetics,179:
1657 1680, 2008 [PDF]
Polytene Chromosomal Maps of 11 Drosophila species: The order of genomic
scaffolds inferred from genetic and physical maps
(Stephen W Schaeffer, Arjun Bhutkar, et al.), Genetics,179: 1601 1655, 2008 [PDF]
Evolution of
genes and genomes on the Drosophila phylogeny (Drosophila 12 Genomes
Consortium), Nature
450(7167):203-18, 2007 [PDF]
Genome-scale
analysis of Positionally Relocated Genes (Arjun Bhutkar, Susan M. Russo,
Temple F. Smith, William M. Gelbart), Genome Research 17(12):1880-7, 2007 [PDF]
Inferring
genome-scale rearrangement phylogeny and ancestral gene order: A Drosophila
case study (Arjun Bhutkar, Temple F. Smith, William M. Gelbart), Genome Biology
8(11):R236, 2007 [PDF]
Techniques
for Multi-Genome Synteny Analysis to Overcome Assembly Limitations (Arjun
Bhutkar, Susan Russo, Temple F. Smith, William M. Gelbart), Genome
Informatics 17(2): 152-161, 2006 [PDF]
Constraining
Ribosomal RNA Conformational Space (P. Favaretto, Arjun Bhutkar, and Temple
F. Smith), Nucleic
Acids Research, 33(16), 2005 [PDF]
Synthetic Biology:
Synthetic
Biology: Navigating the Challenges Ahead J.
BIOLAW & BUS. Vol. 8, No. 2, 2005 [PDF]
Three
Lenses on Synthetic Biology: Patentability, Ethics, Regulation Poster, Synthetic Biology 2.0 Conference, Berkeley CA, 2006
[PDF]
Synthetic
Biology, Social Dimensions and Global Policy: A co-evolutionary
perspective Poster, Synthetic Biology 3.0
Conference, Zurich, 2007 [PDF]
Commentary
on Synthetic Biology: Policy, Society & Systems The Royal Society Call for Views, 2007
[PDF]
Background:
Experience:
2008-Present Research
Scientist, Koch Institute for Integrative Cancer Research, MIT
2006-2008 Fellow,
Dept. of Molecular & Cellular Biology, Harvard University
2004-2006 Joint
research appointment, Dept. of Molecular & Cellular Biology, Harvard
University and BMERC, Boston University
2002-2003 VP
Business Development, Liberato Technologies
1991-2002 Engineering
Department Manager, Intel Corporation
Education:
PhD Bioinformatics, Boston
University, Boston MA.
SM Engineering & Management, MIT Sloan School of Management &
School of Engineering, Cambridge MA.
MS Computer Science, Texas
A&M University, College Station TX.
BE Computer Engineering,
University of Poona, India.
