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Indene bioconversion in Rhodococcus Sp.This organism possesses a rich spectrum of enzymatic activities catalyzing oxygenation and dehydrogenation reactions of high chiral specificity. One product of indene bioconversion is a precursor in the manufacturing of the AIDS drug Crixivan which, however, is formed along with other byproducts. This study examines ways to increase the yield and selectivity of this product through analysis and specific modifications of the indene bioconversion network. People: |
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