Graybiel Laboratory Department of Brain and Cognitive Sciences
McGovern Institute for Brain Research
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Christine Keller-McGandy


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Christine joined the Graybiel lab in 2006 after working for the Neurology Department of the Massachusetts General Hospital in Boston. She will work with striosome and matrix gene expression profiles using laser capture microscopy techniques.

Christine is a native of Switzerland and enjoys traveling back home as well as exploring new countries.

PUBLICATIONS
Cantuti-Castelvetri I, Hernandez LF, Keller-McGandy CE, Kett LR, Landy A, Hollingsworth ZR, Saka E, Crittenden JR, Nillni EA, Young AB, Standaert DG, Graybiel AM. (2010) Levodopa-induced dyskinesia is associated with increased thyrotropin releasing hormone in the dorsal striatum of hemi-parkinsonian rats. PLoS One.  Nov 10; 5 (11): e13861.

Crittenden JR, Cantuti-Castelvetri I, Saka E, Keller-McGandy CE, Hernandez LF, Kett LR, Young AB, Standaert DG, Graybiel AM. (2009) Dysregulation of CalDAG-GEFI and CalDAG-GEFII predicts the severity of motor side-effects induced by anti-parkinsonian therapy. Proc Natl Acad Sci U S A. 106 (8): 2892-6.

Cantuti-Castelvetri I, Keller-McGandy C, Bouzou B, Asteris G, Clark TW, Frosch MP, Standaert DG. Effects of gender on nigral gene expression and parkinson disease. Mar 3 2007. Neurobiol Dis.

Shelbourne PF, Keller-McGandy C, Bi WL, Yoon SR, Dubeau L, Veitch NJ, Vonsattel JP, Wexler NS, Arnheim N, Augood SJ. Triplet repeat mutation length gains correlate with cell-type specific vulnerability in Huntington disease brain. Apr 4 2007 Hum Mol Genet.

St Martin JL, Klucken J, Outeiro TF, Nguyen P, Keller-McGandy C, Cantuti-Castelvetri I, Grammatopoulos TN, Standaert DG, Hyman BT, McLean PJ. Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra. Mar 2007. J Neurochem. 100(6):1449-57.

Sadri-Vakili G, Menon AS, Farrell LA, Keller-McGandy CE, Cantuti-Castelvetri I, Standaert DG, Augood SJ, Yohrling GJ, Cha JH. Huntington inclusions do not down-regulate specific genes in the R6/2 Huntington's disease mouse. Jun 2006. Eur J Neurosci. 23(12):3171-5.

Cantuti-Castelvetri I, Lin MT, Zheng K, Keller-McGandy CE, Betensky RA, Johns DR, Beal MF, Standaert DG, Simon DK. Somatic mitochondrial DNA mutations in single neurons and glia.Nov-Dec 2005. Neurobiol Aging 26(10):1343-55.

Augood SJ, Keller-McGandy CE, Siriani A, Hewett J, Ramesh V, Sapp E, DiFiglia M, Breakefield XO, Standaert DG. Distribution and ultrastructural localization of torsinA immunoreactivity in the human brain. Oct 3 2003. Brain Res. 986(1-2):12-21.

Bi WL, Keller-McGandy C, Standaert DG, Augood SJ. Identification of nitric oxide synthase neurons for laser capture microdissection and mRNA quantification. Biotechniques. 2002 Dec;33(6):1274-83.

Cantuti-Castelvetri I, Keller-McGandy CE, Albers DS, Beal MF, Vonsattel JP, Standaert DG, Augood SJ.Expression and activity of antioxidants in the brain in progressive supranuclear palsy. Brain Res. 2002 Mar 15;930(1-2):170-81.

St Clair WH, Billings PC, Carew JA, Keller-McGandy C, Newberne P, Kennedy AR.Suppression of dimethylhydrazine-induced carcinogenesis in mice by dietary addition of the Bowman-Birk protease inhibitor. Cancer Res. 1990 Feb 1;50(3):580-6.

Billings PC, Carew JA, Keller-McGandy CE, Goldberg AL, Kennedy AR.A serine protease activity in C3H/10T1/2 cells that is inhibited by anticarcinogenic protease inhibitors. Proc Natl Acad Sci U S A. 1987 Jul;84(14):4801-5.

Lieberman MA, Keller-McGandy CE, Woolsey TA, Glaser L. Binding of isolated 3T3 surface membranes to growing 3T3 cells and their effect on cell growth. J Cell Biochem. 1982;20(1):81-93.

Cathomas G, Stalder A, McGandy CE, Mihatsch MJ. Distribution of human herpesvirus 8 DNA in tumorous and nontumorous tissue of patients with acquired immunodeficiency syndrome with and without Kaposi's sarcoma. Mod Pathol. 1998 May;11(5):415-20.

Tamm M, Reichenberger F, McGandy CE, Stalder A, Tietz A, Dalquen P, Perruchoud AP, Cathomas G. Diagnosis of pulmonary Kaposi's sarcoma by detection of human herpes virus 8 in bronchoalveolar lavage.
Am J Respir Crit Care Med. 1998 Feb;157(2):458-63.

Cathomas G, Tamm M, McGandy CE, Itin PH, Gudat F, Thiel G, Mihatsch MJ. Transplantation-associated malignancies: restriction of human herpes virus 8 to Kaposi's sarcoma.
Transplantation. 1997 Jul 15;64(1):175-8.

Cathomas G, Stalder A, McGandy CE, Gudat F, Terracciano LM.Detection of human herpesvirus 8 (HHV 8) in Kaposi sarcomas of the gastrointestinal tract]
Schweiz Med Wochenschr. 1997 Jun 7;127(23):988-91.

Cathomas G, Tamm M, McGandy CE, Itin PH, Gudat F, Thiel G, Mihatsch MJ. Absence of Kaposi's sarcoma-associated human herpes virus 8 in transplantation-related tumors other than Kaposi's sarcoma.
Transplant Proc. 1997 Feb-Mar;29(1-2):836-7.

Cathomas G, McGandy CE, Terracciano LM, Gudat F, Bianchi L. Detection and typing of hepatitis C RNA in liver biopsies and its relation to histopathology.
Virchows Arch. 1996 Dec;429(6):353-8.

Cathomas G, McGandy CE, Terracciano LM, Itin PH, De Rosa G, Gudat F. Detection of herpesvirus-like DNA by nested PCR on archival skin biopsy specimens of various forms of Kaposi sarcoma.
J Clin Pathol. 1996 Aug;49(8):631-3.

Cathomas G, Tamm M, McGandy CE, Perruchoud AP, Mihatsch MJ, Dalquen P. Detection of herpesvirus-like DNA in the bronchoalveolar lavage fluid of patients with pulmonary Kaposi's sarcoma.
Eur Respir J. 1996 Aug;9(8):1743-6.

Cathomas G, McGandy CE, Terracciano LM, Itin PH, DeRosa G, Mihatsch MJ, Gudat F. Detection of herpes virus-like DNA in various forms of Kaposi's sarcoma but not in other mesenchymal tumors or inflammatory changes in skin Verh Dtsch Ges Pathol. 1996;80:318-21.

Cathomas G, McGandy CE, Terracciano LM, Gudat F, Bianchi L.Detection and typing of hepatitis C RNA in liver biopsies in comparison with histopathology Verh Dtsch Ges Pathol. 1995;79:254-7.

Diamantis ID, McGandy CE, Chen TJ, Liaw YF, Gudat F, Bianchi L.Detection of hepatitis B and C viruses in liver tissue with hepatocellular carcinoma. J Hepatol. 1994 Mar;20(3):405-9.

Diamantis ID, McGandy CE, Chen TJ, Liaw YF, Gudat F, Bianchi L.Hepatitis B X-gene expression in hepatocellular carcinoma. J Hepatol. 1992 Jul;15(3):400-3.

Diamantis ID, McGandy CE, Pult I, Widmann JJ, Gudat F, Bianchi L.Detection of hepatitis C virus RNA in liver needle biopsies by polymerase chain reaction. J Hepatol. 1992 Mar;14(2-3):405-6.