Graybiel Laboratory Department of Brain and Cognitive Sciences
McGovern Institute for Brain Research
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Hideki Shimazu

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Hideki received an MD from Shimane University, Japan in 1992 and a PhD in Neurology/Medical Science from Kyoto University in 2000. Most recently Hideki served as the Director of Clinical Neurology at the Itsuki Hospital in Tokushima, Japan, a lecturer for Tokushima University's Department of Neurology, and a Research Fellow for the National Institute for Physiological Sciences in Okazaki.

He has studied the physiological interaction between the premotor cortex (area F5) and the primary motor cortex (M1); the treatment, physiological mechanisms and histological changes in various types of dystonia; as well as a physiological study of the changes in somatosensory evoked potentials (SEP) that occur in the thalamus.

PUBLICATIONS
Shimazu H, Kaji R, Murase N, Kohara N, Ikeda A, Shibasaki H, Kimura J, Rothwell JC. Pre-movement gating of short-latency somatosensory evoked potentials. Neuroreport. 1999 Aug 20;10(12):2457-60.

Shimazu H, Kaji R, Tsujimoto T, Kohara N, Ikeda A, Kimura J, Shibasaki H. High-frequency SEP components generated in the somatosensory cortex of the monkey. Neuroreport. 2000 Aug 21;11(12):2821-6.

Murase N, Kaji R, Shimazu H, Katayama-Hirota M, Ikeda A, Kohara N, Kimura J, Shibasaki H, Rothwell JC. Abnormal premovement gating of somatosensory input in writer's cramp.  Brain. 2000 Sep;123 ( Pt.9):1813-29.

Murase N, Kaji R, Sakamoto T, Shimazu H, Matumoto S, Kohar N, Shibasaki H, Kimura J. Nicotine-sensitive writer's cramp. Mov Disord. 2000 Nov;15(6):1276-9.

Matsumoto S, Nishimura M, Kaji R, Sakamoto T, Mezaki T, Shimazu H, Murase N, Shibasaki H DYT1 mutation in Japanese patients with primary torsion dystonia. Neuroreport. 2001 Mar 26;12(4):793-5.

Cerri G, Shimazu H, Maier MA, Lemon RN. Facilitation from ventral premotor cortex of primary motor cortex outputs to macaque hand muscles. J Neurophysiol. 2003 Aug;90(2):832-42.

Tsujimoto T, Shimazu H, Isomura Y, Sasaki K. Prefrontal theta oscillations associated with hand movements triggered by warning and imperative stimuli in the monkey. Neurosci Lett. 2003 Nov 13;351(2):103-6.

Shimazu H, Maier MA, Cerri G, Kirkwood PA, Lemon RN. Macaque ventral premotor cortex exerts powerful facilitation of motor cortex outputs to upper limb motoneurons. J Neurosci. 2004 Feb 4;24(5):1200-11.

Goto S, Lee LV, Munoz EL, Tooyama I, Tamiya G, Makino S, Ando S, Dantes MB, Yamada K, Matsumoto S, Shimazu H, Kuratsu J, Hirano A, Kaji R. Functional anatomy of the basal ganglia in X-linked recessive dystonia-parkinsonism. Ann Neurol. 2005 Jul;58(1):7-17.

Kaji R, Urushihara R, Murase N, Shimazu H, Goto S. Abnormal sensory gating in basal ganglia disorders. J Neurol. 2005 Oct;252 Suppl 4:IV13-IV16. Review. 

Urushihara R, Murase N, Rothwell JC, Harada M, Hosono Y, Asanuma K, Shimazu H, Nakamura K, Chikahisa S, Kitaoka K, Sei H, Morita Y, Kaji R. Effect of repetitive transcranial magnetic stimulation applied over the premotor cortex on somatosensory-evoked potentials and regional cerebral blood flow. Neuroimage. 2006 Jun;31(2):699-709. Epub 2006 Feb 8.

Tsujimoto T, Shimazu H, Isomura Y. Direct recording of theta oscillations in primate prefrontal and anterior cingulate cortices. J Neurophysiol. 2006 May;95(5):2987-3000. Epub 2006 Feb 8.

Yamada K, Goto S, Matsuzaki K, Tamura T, Murase N, Shimazu H, Nagahiro S, Kuratsu J, Kaji R. Alleviation of camptocormia by bilateral subthalamic nucleus stimulation in a patient with Parkinson's disease. Parkinsonism Relat Disord. 2006 Sep;12(6):372-5. Epub 2006 May 30.

Goto S, Yamada K, Shimazu H, Murase N, Matsuzaki K, Tamura T, Nagahiro S, Kuratsu J, Kaji R. Impact of bilateral pallidal stimulation on DYT1-generalized dystonia in Japanese patients. Mov Disord. 2006 Oct;21(10):1785-7.

Nodera H, Bostock H, Izumi Y, Nakamura K, Urushihara R, Sakamoto T, Murase N, Shimazu H, Kusunoki S, Kaji R. Activity-dependent conduction block in multifocal motor neuropathy: magnetic fatigue test. Neurology. 2006 Jul 25;67(2):280-7.

Yamada K, Goto S, Matsuzaki K, Tamura T, Murase N, Shimazu H, Nagahiro S, Kuratsu J, Kaji R. Alleviation of camptocormia by bilateral subthalamic nucleus stimulation in a patient with Parkinson's  disease.Parkinsonism Relat Disord. 2006 Sep;12(6):372-5. Epub 2006 May 30.

Yamada K, Goto S, Kuratsu J, Matsuzaki K, Tamura T, Nagahiro S, Murase N, Shimazu H, Kaji R. Stereotactic surgery for subthalamic nucleus stimulation under general anesthesia: a retrospective evaluation of Japanese patients with Parkinson's disease. Parkinsonism Relat Disord. 2007 Mar;13(2):101-7. Epub 2006 Oct 19.

Kaji R, Tamiya G, Makino S, Shimazu H, Murase N, Sakamoto T, Tooyama I, Urushihara R.[Dystonia update] Rinsho Shinkeigaku. 2006 Nov;46(11):962. Japanese. No abstract available.

Goto S, Shimazu H, Matsuzaki K, Tamura T, Murase N, Nagahiro S, Kaji R. Thalamic Vo-complex vs pallidal deep brain stimulation for focal hand dystonia.Neurology. 2008 Apr 15;70(16 Pt 2):1500-1.