People at the Graybiel Lab

Kyle Stephen Smith

Email Kyle

Kyle joined the Graybiel lab in 2007 after completing his Masters and Ph.D. in Psychology and Biopsychology at the University of Michigan. He is particularly interested in continuing his work in studying the mechanisms of learning, plasticity and reward.

EDUCATION

2007 Ph.D., University of Michigan
2004 M.S., University of Michigan
2002 B.A., Indiana University
2002 Certificate, Liberal arts and Management Program, Indiana University
2001 Visiting student, University of Oxford, U.K.
2000 Visiting student, University of Michigan

AWARDS & ACTIVITIES

2008-pres NIH Individual National Research Service Award F32
2008-pres Associate faculty member and reviewer, Faculty of 1000 Biology
2008-pres AAAS/Science Program for Excellence in Science
2008 Finalist, Donald B. Lindsley Prize, Society for Neuroscience
2007 Wyvell Award for Most Outstanding Dissertation in Biopsychology, U.M.
2007 Chair and co-organizer, Gordon-Kenan Graduate Research Seminar on Catecholamines.
2007 Honorable mention, Irwin Kopin Young Investigator Award, Gordon Research Conference on Catecholamines
2007 Travel award, Motivational Neural Network Conference, Porquerolles, France
2007 National Science Foundation conference grant, co-PI
2006-07 Biopsychology graduate admissions committee, U.M.
2006 Poster competition award, Michigan Society for Neuroscience meeting
2006 Outstanding graduate student instructor honor roll, department of psychology, U.M.
2006 Departmental associate in psychology, U.M.
2005 Early research award, American Psychological Association
2005 pres Ad hoc reviewer for journals
2002-2005 NIH Institutional National Research Service Award T32
2003-2007 Travel grants & dissertation fellowships, U.M.
2006 Poster competition award, Michigan Society for Neuroscience meeting.
2006 Elected departmental associate in psychology, UMich.
2006 Outstanding graduate student instructor honor roll, department of psychology, UMich.
2005 Early research award, American Psychological Association
2005 Psychology department dissertation grant, UMich.
2003-05 Rackham graduate school travel grants, UMich.
2002-05 Ruth L. Kirschstein National Research Service Award Institutional Research Training Grant.

TALKS

2010 MIT McGovern Institute for Brain Research retreat symposium
2010 MIT Friends of the McGovern Institute symposium
2009 Minisymposium speaker, Society for Neuroscience annual meeting (SFN Hot Topic)
2008 Panel speaker, Winter Conference on Brain Research
2007 Gordon-Kenan Research Seminar on Catecholamines, Oxford, UK
2007 University of Michigan, biopsychology colloquium
2006 Massachusetts Institute of Technology, Ann M. Graybiel laboratory
2005 University of Michigan, Neural Plasticity and Behavior discussion group
2005 University of Michigan, guest lecture for Introduction to Biopsychology course
2003 University of Michigan, biopsychology colloquium

TEACHING

2006 Graduate student instructor for "Drugs of Abuse", U.M.
2005 Graduate student instructor for "Introduction to Biopsychology", U.M.
2005 Mentor to graduate student instructors, U.M.
2004 Graduate student instructor for "Introduction to Biopsychology", U.M.
2002-pres Supervised >20 undergraduates and 6 honors theses, U.M. & M.I.T.

PUBLICATIONS

Smith KS, Berridge KC, Aldridge JW (2011). Disentangling pleasure from incentive salience and learning signals in brain reward circuitry. PNAS, 108(27):E255-64.

Smith KS (2011). Neuronal Correlates of Normal and Drug-Potentiated Pavlovian-Instrumental Transfer. European Journal of Neuroscience, 33:2272-73. Feature commentary on: Saddoris et al., 33:2274-87.

Peciña S*, Smith KS* (2010). Hedonic and motivational roles of opioids in food reward: implications for overeating disorders. Pharmacology, Biochemistry and Behavior, 97(1):34-46. *equal contribution

Smith KS, Mahler SV, Peciña S, Berridge KC (2009). Chapter 1. Hedonic hotspots: brain generation of sensory pleasures. In: Berridge KS and Kringelbach ML (Eds.), Pleasures of the Brain. Oxford, England: Oxford University Press.

Smith KS, Tindell AJ, Aldridge JW, Berridge KC (2009). Ventral pallidum roles in reward and motivation. Behavioural Brain Research, 96(2):155-67.

Tindell AJ, Smith KS, Berridge KC, Aldridge JW (2009). Dynamic computation of incentive salience: 'wanting' what was never 'liked'. The Journal of Neuroscience, 29(39):12220-8. (Editorial highlight: Nature Reviews Neuroscience 10(11):767)

Pennartz CMA, Berke JD, Graybiel AM, Ito R, Lansink CS, van der Meer M, Redish AD, Smith KS, Voorn P (2009). Corticostriatal interactions during learning and memory processing. The Journal of Neuroscience, 29(41):12831-8.

Zhang J, Berridge KC, Tindell AJ, Smith KS, Aldridge JW (2009). A neural computational model of incentive salience. PLoS Computational Biology, 5(7):e1000437.

Smith KS, Berridge KC (2007). Opioid limbic circuit for reward: interaction between hedonic hotspots of nucleus accumbens and ventral pallidum. The Journal of Neuroscience, 27(7):1594-1605. (Editorial highlight: The Journal of Neuroscience, 27(7):i)

Mahler SV, Smith KS, Berridge KC (2007). Endocannabinoids modulate taste 'liking' in the nucleus accumbens. Neuropsychopharmacology, 32(11):2267-78.

Tindell AJ, Smith KS, Peciña S, Berridge KC, Aldridge JW (2006). Ventral pallidum firing codes hedonic reward: when a bad taste turns good. Journal of Neurophysiology, 96:2399-2409. (Feature Commentary: Wheeler RA & Carelli RM, 2175-2176)

Peciña S, Smith KS, Berridge KC (2006). Hedonic hotspots in the brain. The Neuroscientist, 12(6):500- 11.

Smith KS, Berridge KC (2005). The ventral pallidum and hedonic reward: neurochemical maps of 'liking' and food intake. The Journal of Neuroscience, 25(38):8637-49.

F1000 COMMENTARIES

Smith KS, Berridge KC (2010). Evaluation for Fujiyama et al., Eur J Neurosci 2010, 33(4):668-77.
http:// f1000.com/8578962

Smith KS, Berridge KC (2009). Evaluation for Yin, Society for Neuroscience symposium 2009.
http:// f1000.com/1778957#eval1307056

Smith KS, Berridge KC (2009). Evaluation for Wassum et al., Proc Natl Acad Sci 2009, 106(30):12512-7. http://f1000.com/1164382#eval626118

Smith KS, Berridge KC (2009). Evaluation for Tricomi et al., Eur J Neurosci 2009, 29 (11):2225-32. http://f1000.com/1162158#eval622628 (F1000 Hidden Jewel)

Smith KS, Berridge KC (2008). Evaluation for Vijayaraghavan et al., Neuropsychology 2008, 22(3):412- 8. http://f1000.com/1113106#eval569092

CONFERENCE ABSTRACTS

Smith KS, Graybiel AM. Firing Dynamics in Prefrontal Cortical and Striatal Sites Coordinately Promote Habitual Behavior. Society for Neuroscience abstract, 2011.

Smith KS, Graybiel AM. Neural Plasticity in Infralimbic Cortex and Dorsolateral Striatum Associated with Habit Formation. International Basal Ganglia Society conference, 2010.

Smith KS, Graybiel AM. Reward devaluation in a T-maze task shows dynamics of stimulus-response habit formation. Society for Neuroscience abstract, 2009.

Smith KS, Berridge KC. Ventral pallidal neurons distinguish 'liking' and 'wanting' elevations caused by opioids versus dopamine in nucleus accumbens. Society for Neuroscience abstract, 2007. (SFN press release)

Taylor JL, Smith KS, Klein AC, Sakai ST, Aldridge JW. The role of the caudal ventral pallidum in reward and action circuits in the rat. International Basal Ganglia Society conference, 2007.

Smith KS, Berridge KC. Ventral pallidal neurons distinguish 'liking' and 'wanting' elevations caused by opioids versus dopamine in nucleus accumbens. Gordon Research Conference on Catecholamines, 2007.

Smith KS, Berridge KC. Ventral pallidal neurons distinguish 'liking' and 'wanting' elevations caused by opioids versus dopamine in nucleus accumbens. Motivational Neural Networks conference abstract, 2007.

Taylor JL, Smith KS, Klein AC, Sakai ST, Aldridge JW. Ventral pallidal efferents to reward and motor centers in the rat. Michigan Society for Neuroscience abstract, 2007.

Smith KS, Mahler SV, Berridge KC. Intra-accumbens anandamide effects on taste 'liking', feeding and Fos: mapping endocannabinoid reward within accumbens shell. Society for Neuroscience abstract, 2006.

Hoberg PD, Smith KS, Berridge KC. Neurochemical mechanisms of food reward: GABA and opioid regulation of 'liking' in the ventral pallidum. Society for Neuroscience Abstract, 2006.

Smith KS, Berridge KC. Nucleus accumbens and ventral pallidum interact as opioid hotspots to amplify 'liking' and 'wanting' for food reward. Michigan Society for Neuroscience abstract, 2006.

Hoberg PD, Smith KS, Berridge KC. Neurochemical mechanisms of food reward: GABA and opioid regulation of 'liking' in the ventral pallidum. Michigan Society for Neuroscience abstract, 2006.

Smith KS, Berridge KC. The accumbens-pallidum reward pathway: opioid modulation of eating and 'liking'. Society for Neuroscience abstract, 2005.

Jones JJ, Smith KS, Berridge KC. Food reward and the ventral pallidum: dopamine activation of eating and locomotion. Society for Neuroscience abstract, 2005.

Tindell AJ, Smith KS, Berridge KC, Aldridge JW. VP neurons integrate learning and physiological signals to code incentive salience of conditioned cues. Society for Neuroscience abstract, 2005.

Smith KS, Tindell AJ, Berridge KC, Aldridge JW. Ventral pallidal neurons code hedonic enhancement of an NaCl taste after sodium-depletion. Society for Neuroscience abstract, 2004.

Mahler SV, Smith KS, Berridge KC. What is the motivational mechanism of the marijuana munchies? The effects of intra-accumbens anandamide on hedonic taste reactions to sucrose. Society for Neuroscience abstract, 2004. (SFN press release)

Crawley AM, Smith KS, Due M, Smith BR, Farley J. Inhibitory learning in Hermissenda: the effects of backwards- and explicitly-unpaired conditioning. Midwestern Psychology Association abstract, 2004.

Smith KS, Berridge KC. GABA and opioid microinjections in ventral pallidum evoke eating and other motivated behaviors. Society for Neuroscience abstract, 2003.

Farley J, Smith KS, Smith BR. Arachidonic acid decreases spiking and increases IA in Hermissenda type B cells. Society for Neuroscience abstract, 2003.

Smith KS, Berridge KC. GABA and opioid microinjections in ventral pallidum evoke eating and other motivated behaviors. Kyoto-Michigan Collaboration in Psychology on Self, Cognition and Emotion, 2003.