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Particles & Cancer
Janary 10 & 11, 2006
Condado Plaza Hotel, San Juan, Puerto Rico
Massachusetts Institute of Technology, Biological Engineering Division
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Program

Monday, January 9

6 p.m. - 8 p.m.   Welcome reception

Tuesday, January 10

8 a.m. - 5 p.m.   Registration

Introduction: purpose of conference (9 a.m.) R. McCunney, MD, MPH

  • Macro epidemiology of lung cancer W. Thilly, ScD
  • Stem cells as targets of environmental agents E. Gostjeva, PhD
  • Genetic susceptibility to lung cancer D. Christiani, MD, MPH
  • Environmental particulates and lung cancer A. Pope, PhD
  • Pathological studies of particles and lung cancer Speaker tbd
  • Discussion: links env-occ-clinical-path; do particles cause cancer? Moderator tbd

Lunch

  • Issues in Academic Publishing Paul Brandt-Rauf, MD, PhD, ScD

Epidemiology Studies of Selected Particles

  • A cohort mortality study of USA carbon black workers K. Mundt, PhD
  • A cohort mortality study of German carbon black workers J. Wellman, PhD
  • Lung cancer mortality and carbon black exposure – Cox regression analysis of a cohort from a German carbon black production plant P. Morfeld, PhD
  • A nested case-control study of German carbon black workers S. Buchte, PhD
  • Lung cancer risk of European talc workers P. Wild, PhD
  • Mortality among European workers in the titanium dioxide industry. E. Widerpass, PhD
  • Discussion: Key points in interpreting epidemiology studies regarding causal connections between exposure and disease Moderator tbd
  • Lung cancer mortality and carbon black exposure – Uncertainties of SMR analyses in a cohort study at a German carbon black production plant P. Morfeld, PhD

Reception   6 p.m. - 7:30 p.m.
Dinner   7:30 p.m.

Wednesday, January 11

Exposure Characterization and Toxicology of Particles 9 a.m. - 5 p.m.

  • Studies of the Robustness of Industrial Aciniform Aggregates – Carbon Black and Amorpous Silicas C. Gray, PhD
  • Carbon black particles as carriers of exogenous substances: hazard assessment and risk evaluation. P. Borm, PhD
  • Integrating In Vivo, In Vitro, and Epidemiologic Evidence Regarding the Carcinogenicity of Inhaled Carbon Black P. Valberg, PhD
  • Does lung surfactant promote disaggregation of nanostructured titanium dioxide M. Meier, PhD
  • Characterization and reclassification of TiO2 related pulmonary lesions. D. Warheit, PhD
  • Nano sized particles in the workplace and the environment: cause for concern? G.Oberdoerster, PhD
  • Mechanism of lung cancer in lab animals P.Borm, PhD
  • Discussion: Is there a threshold for particles and cancer? P. Morfeld, PhD

Regulatory Issues

  • Regulatory classification of particles regarding risk of cancer – Scientific principles Len Levy PhD

Discussion

  • Research needs and risk assessment of particle exposure Moderator tbd