V.A. Shiva Ayyadurai, Ph.D.

Faculty Lecturer

E-mail: vashiva@mit.edu
Office: 3-237
Office Phone: (617) 617-324-4383
Cell Phone: (617) 617-755-8664

Research Focus

My major interests are in computational systems biology and understanding how traditional medicines interact with biological systems.

Relative to computational systems biology, I am supporting the continuted development of CytoSolve, the product of my Ph.D. research. CytoSolve is now available on the web for those interested on CytoSolve. A great team has continued the work. I'm currently working to test an integrative model of Interferon (IFN) to virus infection on this new web-based version.

Since my return back from India, I am also working to build a Seminar course for the MIT Spring semester on traditional medicines and biological systems. This IAP will be used to test interest in this area. In early IAP a 2-day course will be offered in traditional medicines and systems biology. In the latter part of IAP (January 25 - January 29, 2010), a 5-day series in a symposium and performance format will be offered to explore the power of traditional arts/medicines on the human biological system.

Selected Publications

S. Ayyadurai, Commentary: Innovation Demands Freedom, Nature India, December, 2009.

S. Ayyadurai, A Scalable Computational Architecture for Integrating an Ensemble of Biological Pathway Models, (in submission to Annals of Biomedical Engineering), November 2009.

S. Ayyadurai, Modeling the Cell, Proceedings of BIO-IT Conference, In Silicon Modeling Section, Boston. MA, April 2009.

S. Ayyadurai, Integration of Siddha with Systems Biology,Proceedings of Fullbright Conference 2009, Kolkata, India, March 2009.

S. Ayyadurai, Mission of Systems Biology, Bio-IT Beyond Genome Conference Proceedings, June 2008.

S. Ayyadurai, C.F. Dewey, Jr., Scaleable methods for large molecular pathway calculations: application to EGFR, In Biomedical Engineering Society Annual Fall Meeting, Los Angeles, September 2007.

K. R. Stiehl, K. Dang, S. Ayyadurai, B.-S Seah, S. S. Bhowmick, C. Forbes Dewey, Jr., A New Approach to Database Creation Using Ontologies: OWLdb. K. Dang, K. R. Stiehl , S. Ayyadurai, B.-S Seah, S. S. Bhowmick, C. F. Dewey, Jr., An Information Architecture to Support Molecular Pathway Models., In Biomedical Engineering Society Annual Fall Meeting, Los Angeles, September 2007.

S. Ayyadurai, C.F. Dewey, Jr., Integrating an Ensemble of Biochemical Network Models, In International Society of Computational Biology (ISCB 2007), Vienna, July 2007.

S. Ayyadurai, Cytosolve, In proceedings of the Singapore MIT Symposium for Computational and Systems Biology, January 2007.

S. Ayyadurai, Integrating Biological Pathway Models, In MIT CSBi Oktoberfest Proceedings, Cambridge, October, 2006

S. Ayyadurai, C. Forbes Dewey, Jr., C. Tan, Distributed Computing of Complex Collections of Biological Pathways, In World Congress on Medical Physics and Biomedical Engineering (WC 2006), Seoul, August-September 2006.

S. Ayyadurai, C. F. Dewey, Jr., J. Bassingthwaighte, J. Butterworth, P. Villiger, P. Hunter, Normalization of Biological Pathways, In World Congress on Medical Physics and Biomedical Engineering (WC 2006), Seoul, August-September 2006.

S. Ayyadurai, C.F. Dewey, Jr., Cytosolve: A Distributed Computational Architecture for the Integration of Biomolecular Pathways, In Biomedical Engineering Society Annual Meeting, Chicago, September 2006.

C. F. Dewey, Jr., S. Ayyadurai, V. Rouilly, C. L. Poh, S. S. Bhowmick, J. Evans, R. I. Kitney, Footprints in the Sand: Supporting External Analysis of Medical and Biological Databases, In World Congress on Medical Physics and Biomecal Engineering (WC 2006), Seoul, August-Sept 2006.

S. Ayyadurai, Modeling Actin Polymerization as a System of Integrated Biomolecular Pathways, In Proceedings of the Annual MIT CSBi Oktoberfest, October 2005.

S. Ayyadurai, C.F. Dewey, Jr., Computing unsteady phenomenon across multiple molecular pathways, In Biomedical Engineering Society Annual Meeting, Washington, D.C., September 2005.

S. Ayyadurai, S. A. Cimaszewski, J. H. Williams, Jr.: Unsupervised Classification of Fiber Composite Interphases, In Proceedings of the Second International Conference on Acusto-Electronics, The American Society of Nondestructive Testing, June 24-25, 1993.

A. Gupta, M. V. Nagendraprasad, A. Liu, Patrick Shen-Pei Wang, S. Ayyadurai: An Integrated Architecture for Recognition of Totally Unconstrained Handwritten Numerals, In International Journal of Pattern Recognition and Artificial Intelligence, Vol. 7, No. 4, pp. 757-773, 1993.

G. V. Novakovic, L. E. Freed, S. Ayyadurai, H. Bernstein, Robert S. Langer and C. L. Cooney, Fluid-Dynamic Study of the Enzymatic Fluidized Bed Reactor for Blood Dehparinization, Fluidization VI, In Proceedings of the International Fluidization Conference, Banff, Canada, May 1989.

S. Laxminarayan, O. Mills, L. Rajaram, S. Ayyadurai, L.P. Michelson, Sleep Stage and Apnea Pattern Analysis, In Proceedings of the International Conference on Medical and Biological Engineering, Espoo, Finland, August 1985.