Research

A major challenge in cell biology is to understand how spatiotemporally regulated dynamical interactions between single molecules result in the emergence of specific coordinated function on cellular length-scales. To address this challenge we are developing advanced computational techniques to analyze and integrate high resolution light microscopy data with mechanistic, molecular-based models of fundamental cytoskeletal processes. Our present focus is on chromosome movement during meiosis in oocytes and contractile ring assembly and contraction during cytokinesis. Models are tested and refined via iterative rounds of data analysis, prediction, and cellular perturbation via RNAi and cytoskeletal-disrupting compounds. We additionally pursue in vitro studies of reconstituted cytoskeletal assemblies using cellular extracts and purified proteins to advance our understanding of cytoskeletal dynamics in a controlled, minimalist setting.

Selected Publications

Click here for complete publication listing.