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Department of Biological Engineering
Peter Dedon, M.D., Ph.D.

Peter Dedon, M.D., Ph.D.

Professor of Biological Engineering
Principal Investigator, Singapore-MIT Alliance for Research and Technology Infectious Disease IRG

Research group web site

E-mail: pcdedon@mit.edu
Office: 56-787B
Phone: (617) 253-8017
Fax: (617) 324-5280
Administrative Assistant: Josephina Lee
      Office: 56-787
      Phone: 617-452-2631

Courses: 20.201, Mechanisms of drug action; 20.213, DNA damage and genomic instability; 20.440, Analysis of biological networks


Selected Publications

Chan, C.T.Y., M. Dyavaiah, M.S. DeMott, K. Taghizadeh, P.C. Dedon and T.J. Begley (2010) A quantitative systems approach reveals dynamic control of tRNA modifications during cellular stress. PLoS Genetics, in press.

Chan, S.W.C., and P.C. Dedon (2010) The biological and metabolic fates of endogenous DNA damage products. J. Nucleic Acids, in press.

Lonkar, P., and P.C. Dedon (2010) Reactive species and DNA damage in chronic inflammation: Reconciling chemical mechanisms and biological fates. Int. J. Cancer, in press.

Yun B.H., P.C. Dedon, N.E. Geacintov, V. Shafirovich (2010) One-electron oxidation of a pyrenyl photosensitizer covalently attached to DNA and competition between its further oxidation and DNA hole injection. Photochem. Photobiol. 86: 563-570.

Fu, D., J.A.N. Brophy, C.T.Y. Chan, K.A. Atmore, U. Begley, R.S. Paules, P.C. Dedon, T.J. Begley and L.D. Samson (2010) Human AlkB homolog ABH8 is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival. Mol. Cell Biol. 30: 2449-2459.

Cooke, M., S. Loft, R. Olinski, M. Evans, K. Bialkowski, J. Wagner, P. Dedon, P. Moller, M. Greenberg, and J. Cadet (2010) Recommendations for standardised description of, and nomenclature concerning, oxidatively damaged nucleobases in DNA. Chem. Res. Toxicol. 23: 705-707.

Dedon, P.C. (2010) Oxidation and deamination of DNA by endogenous sources, in Chemical Carcinogenesis, ed. T. Penning. Springer, New York.

Chan, W., L. Wang, B. Chen, K. Taghizadeh, M.S. Demott, P.C. Dedon (2010) Quantification of the 2-deoxyribonolactone and nucleoside 5’-aldehyde products of 2-deoxyribose oxidation in DNA and cells by isotope-dilution gas chromatography mass spectrometry: Differential effects of γ-radiation and Fe+2-EDTA. J. Am. Chem. Soc. 132: 6145-6153.

Fox, J.G., Y. Feng, E.J. Theve, R.C. Fry, J.L.A. Fiala, A.L. Doernte, M. Williams, A.R. Raczynski, J.L. McFaline, J.M. Essigmann, D.B. Schauer, S.R. Tannenbaum, P.C. Dedon, S.A. Weinman, S.M. Lemon, A.B. Rogers (2010) Gut microbes define liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens. Gut 59: 88-97.

Margolin, Y., and P.C. Dedon (2010) A general method for quantifying sequence effects on nucleobase oxidation in DNA. Meth. Molec. Biol. 610: 325-340

Rai, P., T.T. Onder, J.J. Young, J.L. McFaline, B. Pang, P.C. Dedon and R.A. Weinberg (2009) Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence. Proc. Nat. Acad. Sci. USA, 106: 169-74.

DeMott, M.S., and P.C. Dedon (2009) The chemistry of inflammation and DNA damage: biological impact of reactive nitrogen species, in The Chemical Biology of DNA Damage, ed. N. Geacintov, S. Broyde. Wiley-VCH, Weinheim, in press.

Prestwich, E.G., and P.C. Dedon (2009) Endogenous DNA damage, in Endogenous Toxins: Diet, Genetics, Disease and Treatment, ed. P.J. O’Brien, R.W. Bruce. Wiley-VCH, Wienheim, in press.

Barth, M.C., D.A. Dederich and P.C. Dedon (2009) Using ionic strength to control supercoiling in large-scale preparations of positively and negatively supercoiled plasmid DNA. Biotechniques 47: 633-635.

Lee, Y.A., A. Durandin, P.C. Dedon, N.E. Geacintov, and V. Shafirovich (2008) Oxidation of guanine in G, GG, and GGG sequence contexts by aromatic pyrenyl radical cations and carbonate radical anions: Relationship between kinetics and distribution of alkali-labile lesions. J. Phys. Chem. B, 112: 1834-1844.

Son, J., B. Pang, J. McFaline, K. Taghizadeh, P.C. Dedon (2008) Surveying the damage: The challenges of developing nucleic acid biomarkers of inflammation. Molecular Biosys., 4: 902-908.

Ringvoll, J., M.P. Nabong, L.M. Nordstrand, L.B. Meira, B. Pang, A. Bekkelund, P.C. Dedon, S. Bjelland, L.D. Samson, P.Ø. Falnes, and A. Klungland (2008) AlkB homolog 2 (ABH2) is the principle dioxygenase for repair of ethenoadenine lesions in mammalian DNA. Cancer Res., 68: 4142-4149.

Meira, L.B., J.M. Bugni, S.L. Green, C.-W. Lee, B. Pang, D. Borenshtein, B.H. Rickman, A.B. Rogers, C.A. Moroski, J.L. McFaline, D.B. Schauer, P.C. Dedon, J.G. Fox and L.D. Samson (2008) DNA damage induced by chronic inflammation contributes to colon carcinogenesis. J. Clin. Invest., 118: 2516-2525.

Taghizadeh, K., J.L. McFaline, B. Pang, M. Sullivan, M. Dong, E. Plummer, and P.C. Dedon (2008) Quantification of DNA damage products resulting from deamination, oxidation and reaction with products of lipid peroxidation by liquid chromatography isotope dilution tandem mass spectrometry. Nat. Protocols, 3: 1287-1298.

Lim, C.-H., P.C. Dedon and W.M. Deen (2008) Kinetic analysis of intracellular concentrations of reactive nitrogen species. Chem. Res. Toxicol., 21: 2134-47.

Margolin, Y., V. Shafirovich, N.E. Geacintov, M.S. DeMott and P.C. Dedon (2008) DNA sequence context as a determinant of the quantity and chemistry of guanine oxidation produced by hydroxyl radicals and one-electron oxidants. J. Biol. Chem., 283: 35569-35578.
Pang, B., X. Zhou, H. Yu, M. Dong, K. Taghizadeh, J.S. Wishnok, S.R. Tannenbaum and P.C. Dedon (2007) Lipid peroxidation dominates the chemistry of DNA adduct formation in a mouse model of inflammation. Carcinogenesis 8: 1807-1813.

Yun BH, Lee YA, Kim SK, Kuzmin V, Kolbanovskiy A, Dedon PC, Geacintov NE, Shafirovich V. (2007) Photosensitized oxidative DNA damage: from hole injection to chemical product formation and strand cleavage. J. Am. Chem. Soc. 129: 9321-9332

Lee, Y.A., B.H. Yun, S.K. Kim, Y. Margolin, P.C. Dedon, N.E. Geacintov and V. Shafirovich (2007) Mechanisms of guanine oxidation in DNA by carbonate radical anion, a decomposition product of nitrosoperoxycarbonate. Chemistry 3: 4571-81.

Kim MY, Zhou X, Delaney JC, Taghizadeh K, Dedon PC, Essigmann JM, Wogan GN (2007) AlkB Influences the Chloroacetaldehyde-Induced Mutation Spectra and Toxicity in the pSP189 supF Shuttle Vector. Chem Res Toxicol. 20: 1075-1083.

Dedon, P.C., M. DeMott, E. Elmquist, E. Prestwich, B. Pang, J. McFaline (2007) The challenges of developing DNA and RNA biomarkers of inflammation. Biomarkers Med., 1: 293-312.

Chen, B., Z. Xinfeng Zhou, K. Taghizadeh, J. Chen, J. Stubbe and P.C. Dedon (2007) GC-MS methods to quantify the 2-deoxypentos-4-ulose and 3'-phosphoglycolate pathways of 4'-oxidation of deoxyribose: Application to DNA damage produced by γ-radiation and bleomycin. Chem. Res. Toxicol., 20: 1701-1708.

Dedon, P.C. (2007) The chemical toxicology of 2-deoxyribose oxidation in DNA. Chem. Res. Toxicol., 21: 206-219.

Wang, L., Chen, S., Xu, T., Taghizadeh, K., Wishnok, J., Zhou, X., You, D., Deng, Z., Dedon, P.C. (2007) Phosphorothioation of DNA in bacteria by dnd genes. Nat. Chem. Biol., 3: 709-710.

Dong, M. and P.C. Dedon (2006) Relatively small increases in the steady-state levels of nucleobase deamination products in DNA from human TK6 cells exposed to toxic levels of nitric oxide. Chem. Res. Toxicol. 19: 50-57.

Zipes, D., M. Pfeffer, N. Zvaifler, R. Glassock, S. Gilman, A. Muñoz, V. Gogolak, L. Gordis, P. Dedon, F. Guengerich, S. Wasserman, J. Witztum, and G. Wogan (2006) Rosuvastatin: An independent analysis of risks and benefits. MedGenMed, 8: 73; available at: http://medgenmed.medscape.com/viewarticle/533930.

Li, C.-Q., B. Pang, T. Kiziltepe, L.J. Trudel, B.P. Engelward,P.C. Dedon, and G.N. Wogan (2006) Threshold effects of nitric oxide-induced toxicity and cellular responses in wild-type and p53-null human lymphoblastoid cells. Chem. Res. Toxicol., 19: 399-406.

Margolin, Y., J.-F. Cloutier, V. Shafirovich, N. Geacintov and P.C. Dedon (2006) Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation. Nature Chem. Biol. 2: 365-366.

 

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