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Department of Biological Engineering
James G. Fox, D.V.M.

James G. Fox, D.V.M.

Director and Professor, Division of Comparative Medicine and Biological Engineering

Research group web site

E-mail: jgfox@mit.edu
Office: 16-825C
Phone: (617) 253-1757
Fax: (617) 253-5708
Administrative Assistants: Lucy Wilhelm

Research Focus

Dr. James Fox is a Professor and Director of the Division of Comparative Medicine and a Professor in the Department of Biological Engineering at the Massachusetts Institute of Technology. He is also an Adjunct Professor at Tufts University School of Veterinary Medicine and the University of Pennsylvania, School of Veterinary Medicine. He is a Diplomate and a past president of the American College of Laboratory Animal Medicine, past president of the Massachusetts Society of Medical Research, past chairman of AAALAC Council, past chairman of the NCCR/NIH Comparative Medicine Study Section and current president of the American Association of Veterinary Medical Colleges. He is also a member of various other organizations including AAAS, AALAS, AVMA, AAVMC, IDSA, ACLAM and ASM. He also is an elected fellow of the Infectious Disease Society of America, a past or current member of the Board of Directors of Public Responsibility in Medicine and Research (PRIM&R), ACLAM, ACLAD, AAALAC, MSMR, and AAVMC. Professor Fox is the author of over 490 articles, 80 chapters, 4 patents and has edited and authored 13 texts, in the field of in vivo model development and comparative medicine. He has given over 250 invited lectures, consults nationally and internationally with government, academia and industry, has served on the editorial board of several journals, is a past member of the NIH/NCRR Scientific Advisory Council, and a current member of ILAR Council of the National Academy of Sciences.

Dr. Fox was elected to the Institute Medicine of the National Academy of Sciences in 2004. He has received numerous scientific awards including the AVMA’s Charles River Prize in Comparative Medicine, the AALAS Nathan Brewer Scientific Achievement Award, and the AVMA/ASLAP Excellence in Research Award. In 2006, Dr. Fox received the Distinguished Alumni Award from Colorado State University and in 2007 was selected as the inaugural recipient of the American College of Laboratory Animal Medicine Comparative Medicine Scientist Award. Dr. Fox was recently elected as an honorary member of the European Helicobacter Study group, and is the 2008 recipient of the American Association for Laboratory Animal Science Charles A. Griffin Award. He has been studying infectious diseases of the gastrointestinal tract for the past 35 years and has focused on the pathogenesis of Campylobacter spp. and Helicobacter spp. infection in humans and animals. His laboratory developed the ferret as a model for both campylobacter and helicobacter associated disease as well as the first rodent model to study helicobacter associated gastric disease, including gastric cancer. Dr. Fox is considered an international authority on the epidemiology and pathogenesis of enterohepatic helicobacters in humans and animals. He is largely responsible for identifying, naming, and describing many of the diseases attributed to various Helicobacter species; most notably their association with hepatitis, liver tumors, inflammatory bowel disease and colon cancer. His laboratory most recently has described the pivotal role that Helicobacter spp. play in the development of cholesterol gallstones in mice fed a lithogenic diet; thus linking this finding to his earlier description of Helicobacter spp. associated chronic cholecystitis and gallstones in Chilean women, a population at high risk of developing gallbladder cancer. He also has had a long-standing interest in zoonotic diseases as well as biosafety issues associated with in vivo models.

His past and current research has been funded by NIH and NCI, as well as by private industrial sources, for the past 35 years. He has been the principal investigator of an NIH postdoctoral training grant for veterinarians for the past 20 years and has trained 50 veterinarians for careers in biomedical research. He also has a NIH training for veterinary students and has introduced over 100 veterinary students to careers in biomedical research. He recently chaired a committee for the National Academy of Sciences which published a report entitled "National Need and Priorities for Veterinarians in Biomedical Research" which highlights the urgent need for increased numbers of veterinarians involved in the biomedical research arena. He is a past member of NAS "Committee to Assess the Current and Future Workforce Needs in Veterinary Medicine".

Selected Publications

Saunders KE, Shen Z, Dewhirst FE, Paster BJ, Dangler CA, Fox JG. Novel intestinal Helicobacter species isolated from cotton-top tamarins (Saguinus oedipus) with chronic colitis. J Clin Microbiol 37:146-151, 1999.

Lichtenberger LM, Dial EJ, Ottlecz A, Romero JJ, Lechago J, Fox JG. Attenuation of hydrophobic phospholipid barrier is an early event in Helicobacter felis-induced gastritis in mice. Dig Dis Sci 44: 108-115, 1999.

Jackson L, Trudel LJ, Fox JG, Lipman NS. Monoclonal antibody production in murine ascites I: Clinical and pathological features. Lab Anim Sci 49: 70-80, 1999.

Jackson L, Trudel LJ, Fox JG, Lipman NS. Monoclonal antibody production in murine ascites II: Production characteristics. Lab Anim Sci 49:81-86, 1999.

Fox JG, Gorelick PL, Kullberg M, Ge Z, Dewhirst FE, Ward JM. A novel urease negative Helicobacter species associated with colitis and typhlitis in IL-10 deficient mice. Infection and Immunity 67:1757-1762, 1999.

Koh TJ, Dockray GJ, Varro A, Cahill RJ, Dangler CA, Fox JG, Wang TC. Overexpression of glycine-extended gastrin in transgenic mice results in increased colonic proliferation. J Clin Invest 103: 1119-1126, 1999.

Ihrig M, Schrenzel M, Fox JG. Differential susceptibility to hepatic inflammation and proliferation in AXB recombinant inbred mice chronically infected with Helicobacter hepaticus. Am J Pathol 155: 571-582, 1999.

Jacoby RO, Fox JG. Federal support for training in laboratory animal medicine should be reinstated (editorial). Lab Anim Sci 49: 348, 1999.

Shomer NH, Astrofsky KM, Dangler CA, Fox JG. Biomethod for obtaining gastric juice and serum from the unanesthetized guinea pig (Cavia porcellus). Contemporary Topics in LAS 38: 32-35, 1999

Dewhirst FE, Chien CC, Paster BJ, Ericson RL, Orcutt R, Schauer DB, Fox JG. Phylogeny of the defined murine microbiota: Altered Schaedler Flora. App Environ Microbiol 65: 3287-3292, 1999.

Batchelder MA, Bell JA, Erdman SE, Marini RP, Murphy JC, Fox JG. Pregnancy toxemia in the European ferret (Mustela putorius furo). Lab Anim Sci 49: 372-379, 1999.

Foley JE, Marks S, Munson L, Melli A, Dewhirst DE, Yu S, Shen Z, Fox JG. Isolation of Helicobacter canis from a colony Bengal cats with endemic diarrhea. J Clin Microbiol 37: 3271-3275, 1999.

Fox JG, Dangler CA, Taylor NS, King A, Koh T, Wang T. High salt diet induces gastric epithelial hyperplasia, parietal cell loss, and enhances Helicobacter pylori colonization in C57BL/6 mice. Cancer Research 59: 4823-4828, 1999.

Marini RP, Fox JG, Taylor NS, Yan L, McColm A, Williamson R. Ranitidine bismuth citrate and clarithromycin alone or in combination, for eradication of Helicobacter mustelae infection in ferrets. Am J Vet Res 60: 1280-1286, 1999.

McCathey S, Shomer NH, Schrenzel MD, Whary MT, Taylor NS, JG Fox. Colonization and tissue tropism of Helicobacter pylori and a novel urease-negative intestinal Helicobacter in ICR mice are independent of route of exposure. Helicobacter 4: 249-259, 1999.

Wang TC, Dangler CA, Chen D, Goldenring JR, Koh T, Raychowdhury R, Coffey RJ, Ito S, Varro A, GJ Dockray, Fox JG. Synergistic interaction between hypergastrinemia and helicobacter infection in a mouse model of gastric cancer. Gastroenterology 118: 36-47, 2000.

Esteves MI, Schrenzel MD, Marini RP, Taylor NS, Xu S, Hagen S, Feng Y, Shen Z, Fox JG. Helicobacter pylori gastritis in cats with long term natural infection as a model of human disease. Am J Pathol 156: 709-721, 2000.

Whary MT, Cline JH, King AE, Corcoran CA, Xu Shilu, Fox JG. Containment of Helicobacter hepaticus by use of husbandry practices. Comp Med 50: 78-81, 2000.

Young VB, Dangler CA, Fox JG, Schauer DB. Chronic atrophic gastritis in SCID mice experimentally infected with Campylobacter fetus. Infect Immun 68:2110-2118, 2000.

Fox JG, Beck P, Dangler CA, Whary MT, Wang TC, Shi HN, Nagler-Anderson, C. Concurrent enteric helminth infection modulates inflammation and gastric immune response and reduces Helicobacter-induced gastric atrophy. Nat Med 6: 536-542, 2000.

Fox JG, Dangler CA, Snyder SB, Richard MJ, Thilsted JP. C-cell (medullary thyroid carcinoma) associated with multiple endocrine neoplasms in a ferret (Mustela putorius). Vet Pathol 37: 278-282, 2000.

Chien CC, Taylor NS, Ge Z, Schauer DB, Young VB, Fox JG. Identification of cdtB homologues and cytolethal distending toxin activity in enterohepatic Helicobacter spp. J Med Micro 49: 525-534, 2000.

Fox JG, Chien CC, Dewhirst FE, Paster BJ, Shen Z, Melito PL, Woodward DL, Rodgers. FG. Helicobacter canadensis sp. nov. isolated from humans with diarrhea as an example of an emerging pathogen. J Clin Microbiol 38: 2546-2549, 2000.

Young VB, Chien CC, Taylor NS, Knox KA, Schauer DB, Fox JG. Cytolethal distending toxin in avian and human isolates of Helicobacter pullorum. J. Infect Dis 182:620-623, 2000.

Shen Z, Feng Y, Fox JG. Identification of enterohepatic Helicobacter species by restriction fragment length polymorphism analysis of the 16S rRNA gene. Helicobacter 5: 121-128, 2000.

Patterson MM, Schrenzel MD, Feng Y, Xu S, Dewhirst FE, Paster BJ, Thibodeau SA, Versalovic J, Fox JG. Helicobacter aurati sp. nov., a urease-positive Helicobacter species cultured from gastrointestinal tissues of Syrian hamsters. J Clin Microbiol 38: 3722-3728, 2000.

Whary MT, Cline JH, King AE, Hewes KM, Chojnacky D, Salvarrey A, Fox JG. Monitoring sentinel mice for Helicobacter hepaticus, H. rodentium and H. bilis infection by PCR and serology. Comp Med 50: 436-443, 2000.

Patterson MM, Schrenzel MD, Feng Y, Fox JG. Gastritis and intestinal metaplasia in syrian hamsters infected with Helicobacter aurati and two other microaerobes. Vet Pathol 37: 589-596, 2000.

Dial EJ, Hall LR, Romero JJ, Lechago J, Fox JG, Lichtenberger LM. Altered gastrin regulation in mice infected with Helicobacter felis. Dig Dis Sci 45: 1308-1314, 2000.

Dewhirst FD, Fox JG, Mendes EN, Paster BJ, Gates CE, Kirkbride CA, Eaton KA. Flexispira rappini strains represent at least ten Helicobacter taxa. Int J Syst Evol Microbiol 50: 1781-1787, 2000.

Ge Z, Feng Y, Dangler CA, Xu S, Tayor NS, Fox JG. Fumarate reductase is essential for Helicobacter pylori colonization of the mouse stomach. Microbial Pathogenesis 29: 279-287, 2000.

Kwon H, Pena JA, Osato MS, Fox JG, Graham DY, Versalovic J. Frameshift mutations in rdxA and metronidazole resistance in North American Helicobacter isolates. J Antimicrobiol Chemother 46: 793-796, 2000.

Harper CMG, Dangler CA, Xu S, Feng Y, ShenZ, Sheppard BJ, Stamper A, Dewhirst, FE, Paster BJ, Fox JG. Isolation and characterization of Helicobacter sp. from the gastric mucosa of dolphins, Lagenorhynchus acutus and Delphinus delphis. App Environ Microbiol 66: 4751-4757, 2000.

Bergin IL, Chien CC, Marini RP, Fox JG. Isolation and characterization of Corynebacterium ulcerans from cephalic implants in rhesus macaques (Macaca mulatta). Comp Med 50: 530-535, 2000.

Kwiecien JM, Blanco M, Fox JG, Delaney KH, Fletch AL. Neuropathology of bouncer long evans, a novel dysmyelinated rat. Comp Med 50: 503-510, 2000.

Fox JG, Wang TC. The ‘African enigma’-another explanation (letter). Nat Med 6: 1297-1298, 2000.

Chin EY, Dangler CA, Fox JG, Schauer DB. Helicobacter hepaticus infection triggers inflammatory bowel disease in T cell receptor ab mutant mice. Comp Med 50: 586-592, 2000.

Astrofsky KM, Schrenzel MD, Bullis RA, Smolowitz RM, Fox JG. Diagnosis and management of atypical Mycobacterium spp. infections in established laboratory zebrafish (Brachydanio rerio) facilities. Comp Med 50: 660-672, 2000.

Dewhirst FE, Fox JG, On SLW. Recommended minimal standards for describing new species of the genus Helicobacter. Int J Syst Evol Bacteriol 50: 2231-2237, 2000.

Gasbarrini A, Fox JG, Gasbarrini G. Helicobacter pylori and other Helicobacter spp. chronic infections and extragastric diseases. European J of Gastroenterol and Hepatol 12: 1057-1060, 2000.

Fox JG, Marini RP. Helicobacter mustelae infection in ferrets: Pathogenesis, epizootiology, diagnosis and treatment. Sem in Avian and Exotic Pet Med 10: 36-44, 2001.

Erdman SE, Fox JG, Dangler CA, Feldman D, Horwitz B. Cutting edge: typhlocolitis in NF-kB deficient mice. J Immunol 66: 1443-1447, 2001.

Simpson KW, Strauss-Ayali D, Straubinger RK, Scanziani E, McDonough PL, Straubinger AF, Chang YF, Esteves MI, Fox JG, Domeneghini C, Arebi N, Calam J. Helicobacter pylori infection in the cats: evaluation of gastric colonization, inflammation and function. Helicobacter 6: 1-14, 2001.

Fox JG, Handt L, Sheppard BJ, Xu S, Dewhirst FE, Motzel S, Klein H. Isolation of Helicobacter cinaedi from the colon, liver and mesenteric lymph node of a rhesus monkey with chronic colitis and hepatitis. J Clin Microbiol 39: 1580-1585, 2001.

Ge Z, Doig P, Fox JG. Characterization of proteins in the outer membrane preparation of a murine pathogen, Helicobacter bilis. Infect Immun 69: 3502-3506, 2001.

Peña JA, Fox JG, Ferraro MJ, Versalovic J. Molecular resistance testing of Helicobacter pylori in gastric biopsies. Arch Pathol Lab Med 125:493-497, 2001.

Fox JG, Handt L, Xu S, Shen Z, Dewhirst FE, Paster BJ, Dangler CA, Lodge K, Motzel S, Klein H. Novel Helicobacter species isolated from rhesus monkeys with chronic idiopathic colitis. J. Med Microbiol 50: 421-429, 2001.

Ihrig M, Dangler CA, Fox JG. Mice lacking inducible nitric oxide synthase develop spontaneous hypercholesterolaemia and aortic atheromas. Atherosclerosis 156: 103-107, 2001.

Shomer NH, Dangler CA, Schrenzel MD, Whary MT, Xu S, Feng Y, Paster BJ, Dewhirst FE, Fox JG. Cholangiohepatitis and inflammatory bowel disease (IBD) induced by a novel urease-negative Helicobacter species in A/J and Tac:ICR:Hascid mice. Biol & Exp Med 226: 420-428, 2001.

Fox JG. Human diseases associated with non-H. pylori helicobacters. Helicobacter Res 5: 35-44, 2001.

Shen Z, Feng Y, Dewhirst FE, Fox JG. Coinfection with enteric Helicobacter spp. and Campylobacter spp. in cats. J Clin Microbiol 39: 2166-2172, 2001.

Fox JG, Wang TC, Nagler-Anderson C. The African enigma: the parasite’s perspective (letter). Gut 48: 156-157, 2001.

Garcia A, Erdman SE, Sheppard BJ, Murphy JC, Fox JG. Gastric dilatation syndrome associated with chronic nephropathy hypergastrinemia, and gastritis in mice exposed to high levels of environmental antigens. Comp Med 51: 262-267, 2001.

Ge Z, White DA, Whary MT, Fox JG. Fluorogenic PCR-based quantitative detection of a murine pathogen Helicobacter hepaticus J Clin Microbiol 39:2598-2602, 2001.

Newman JV, Kosaka T, Sheppard BJ, Fox JG, Schauer DB. Bacterial infection promotes colon tumorigenesis in Apc Min/+ mice. J Infect Dis 184: 227-230, 2001.

Dykstra MJ, Astrofsky KM, Schrenzel MD, Fox JG, Bullis RA, Farrington S, Sigler L, Rinaldi MG, McGinnis MR. High mortalities in a large scale zebrafish colony (Brachydanio rerio Hamilton & Buchanan, 1822) associated with Lecythophora mutablis (van Beyma) W. Gams & McGinnis. Comp Med 51: 361-368, 2001.

Fox JG, Schauer DB, Wadstrom T. Enterohepatic Helicobacter spp. Current Opinion in Gastroenterol (suppl 1) 17: S28-S31, 2001.

Fox JG, Wang TC. Helicobacter pylori is a bad bug after all (editorial). N Engl J Med 345: 829-832, 2001.

Fox JG. Isolation of a Helicobacter strain from the human liver (letter). Gastroenterol 121: 1023-1024, 2001.

Ge Z, Feng Y, White D, Schauer DB, Fox JG. Genomic characterization of Helicobacter hepaticus: ordered cosmid library and comparative sequence analysis. FEMS Microbiol Lett 204: 147-153, 2001.

Franklin CL, Gorelick PL, Riley LK, Dewhirst FE, Livingston RS, Ward JM, Beckwith CS, Fox JG. Helicobacter typhlonius sp. nov., a novel murine urease-negative Helicobacter species. J Clin Microbiol 39: 3920-3926, 2001.

Whary MT, Cline J, King A, Ge Z, Shen Z, Sheppard B, Fox JG. Long term colonization levels of Helicobacter hepaticus in the cecum of hepatitis-prone A/JCr mice are significantly lower than those in hepatitis-resistant C57BL/6 mice. Comp Med 51:413-417, 2001.

Falush D, Kraft C, Taylor NS, Correa P, Fox JG, Achtman M, Suerbaum S. Recombination and mutation during long-term gastric colonization by Helicobacter pylori: estimates of clock rates, recombination size and minimal age. Proc Natl Acad Sci 98: 15056-15061, 2001.

Fox JG. The non- H. pylori helicobacters: Their expanding role in gastrointestinal and systemic diseases. Gut 50: 273-283, 2002.

Garcia A, Erdman SE, Feng Y, Rogers AB, Schrenzel MD, Murphy JC, Fox JG. Hepatobilary inflammation, neoplasia, and argyrophilic bacteria in a ferret colony. Vet Pathol 39: 173-179, 2002.

Astrofsky KM, Harper CM, Rogers AB, Fox JG. Diagnostic techniques for clinical investigation of laboratory zebrafish. Lab Anim 31: 41-45, 2002.

Fox JG, Wang TC. Helicobacter pylori infection: pathogenesis. Current Opinion in Gastroenterol 18: 15-25, 2002.

Fox JG, Sheppard BJ, Dangler CA, Whary MT, Ihrig M, Wang TC. Germline p53 mutation inhibits Helicobacter-induced premalignant lesions and invasive gastric carcinoma through downregulation of Th1 proinflammatory responses. Can Res 62:696-702, 2002.

Suerbaum S, Kraft C, Dewhirst FE, Fox JG. Helicobacter nemestrinae ATCC 49396T is a strain of Helicobacter pylori. Int J Syst Evol Microbiol 52:437-439, 2002.

Harper CMG, Xu S, Feng Y, Dunn JL, Taylor NS, Dewhirst FE, Fox JG. Identification of novel Helicobacter spp. from beluga whale. Appl Environ Microbiol 68:2040-2043, 2002.

Pena JA, McNeil K, Fox JG, Versalovic J. Molecular evidence of Helicobacter cinaedi-organisms in human gastric biopsy specimens. J Clin Microbiol 40:1511-1513, 2002.

Houghton J, Fox JG, Wang TC. Helicobacter pylori and other causes of gastric ulceration. Gastric cancer-Lab bench to clinic. J Gastroenterol Hepatol: 17: 495-502, 2002.

Fox JG. Other helicobacters involved in human diseases. Acta Gastroenterologica Belgica 65: 24-31-2002.

Fox JG, Xu S, Shen Z, Feng Y, Dangler CA, Dewhirst FE, Paster BJ, Cullen JM. Helicobacter marmotae sp. nov. isolated from livers of woodchucks and intestines of cats J. Clin Microbiol 40: 2513-2519, 2002.

Astrofsky KM, Schech JM, Sheppard BJ, Obenschain CA, Chin AM, Kacergis MC, Laver ER, Bartholomew JL, Fox JG. High mortality due to Tetrahymena sp. infection in laboratory maintained zebrafish (Brachydanio rerio). Comparative Medicine 52: 363-367, 2002.

Matsukura N, Yokomuro S, Yamada S, Tajiri T, Takashi T, Sundo T, Hadama T, Kamiya S, Fox JG. Association between Helicobacter bilis in bile and biliary tract malignancies: H. bilis in bile from Japanese and Thai patients with benign and malignant diseases in the biliary tract. Japanese J Can Res 93: 842-847, 2002.

Astrofsky KM, Roux MM, Klimpel KR, Fox JG, Dhar AK. Isolation of differentially expressed genes from white spot virus (WSV) infected Pacific blue shrimp (Penaeus stylirostris). Arch Virol 147: 1799-1812, 2002.

Harper C, Feng Y, Xu S, Taylor NS, Kinsel M, Dewhirst FE, Paster B, Greenwell M, Levine G, Rogers A, Fox JG. Helicobacter cetorum sp. nov., a urease positive Helicobacter species isolated dolphins and whales. J Clin Microbiol 40: 4536-4543, 2002.

Garcia A, Marini RP, Feng Y, Vitsky A, Taylor NS, Schauer DB, Fox JG. A naturally occurring rabbit model of enterohemorrhagic Escherichia coli-induced disease. J Infect Dis 186:1682-1686,2002.

Erdman SE, Poutahidis T, Rogers AB, Tomczak M,Cormier K, Horwitz BH, Fox JG. CD4+ CD45Rblo regulatory T lymphocytes inhibit microbially-induced colon cancer in Rag2-deficient mice. Am J Path 162: 691-702, 2003.

Todorova MT, Dangler CA, Drage MG, Sheppard BJ, Fox JG, Seyfried TN. Sexual dysfunction and sudden death in epileptic male EL mice: inheritance and prevention with the ketogenic diet. Epilepsia 44: 25-31, 2003

Fox JG, Rogers AB, Ihrig M, Taylor NS, Whary MT, Dockray G, Varro A, Wang TC. Helicobacter pylori associated gastric cancer in INS-GAS mice is gender-specific Cancer Res 63: 942-950, 2003.

Bergin IL, Sheppard BS, Fox JG. Helicobacter pylori infection and high dietary salt independently induce atrophic gastritis and intestinal metaplasia in outbred US bred Mongolian gerbils. Dig Dis Sci 48: 475-485, 2003.

Patterson MM, O’Toole PW, Forester N, Noonan B, Trust TJ, Xu S, Taylor NS, Marini RP Fox JG. Failure of surface ring-mutant strains of Helicobacter mustelae to persistently infect the ferret stomach. Infect Immun 71: 2350-2355, 2003

Fox JG, Wang TC, Rogers AB, Taylor NS, Dangler CA, Ge Z, Israel DA, Krishna U, Gaus K, Peek, RM. Host and microbial determinants influence Helicobacter pylori-induced gastric carcinogenesis in murine model of hypergastrinemia. Gastroenterology 124: 1879-1890, 2003.

Patterson MM, Rogers AB, Schrenzel MD, Marini RP, Fox JG. Alopecia attributed to neoplastic ovarian tissue in two ferrets Comp Med 53: 213-217, 2003

Shomer NH, Fox JG, Juedes A, Ruddle NH. Helicobacter-induced chronic active lympoid aggregates have characteristics of tertiary lymphoid tissue. Infect Immun 71: 3572-3577, 2003.

Schwarz L, Solano M, Manning A, Marini RP, Fox JG. The normal upper gastrointestinal examination in the ferret. J Vet Radiol 44: 165-172, 2003.

Suerbaum S, Josenhans C, Sterzenbach T, Bell M, Brandt P, Chevreux B, Drescher B, Droege M, Fartmann B, Fischer HP, Ge Z, Shen Z, Hörster A, Holland R, Mendz G, Macko L, Nyakatura G, Paquette J, Schauer D, Weber J, Frosch M, Fox JG. The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus. Proc Natl Acad Sci 100: 7901-7906, 2003.

Rogers AB, Fox JG. Inflammation and Cancer. I. Rodent models of infectious gastrointestinal and liver cancer. Am J Physiol-Gastr L 286:G361-G366, 2004.

Fox JG, Rogers AB, Whary MT, Ge Z, Taylor NS, Xu S, Horwitz B, Erdman SE. Gastroenteritis in NF-ɻB deficient mice is produced with wildtype Camplyobacter jejuni but not with C. jejuni lacking cytolethal distending toxin despite persistent colonization with both strains. Infect Immun 72:1116-1125, 2004.

Sarma-Rupavtarm RB, Ge Z, Schauer DB, Fox JG, Polz MF. Spatial distribution and stability of the eight microbial species of the Altered Schaedler Flora in the mouse gastrointestinal tract. Appl Environ Microb 70:2791-2800, 2004.

Maurer KJ, Marini RP, Fox JG, Rogers AB. Polycystic kidney syndrome in New Zealand White rabbits resembling human polycystic kidney disease. Kidney Int 65:482-489, 2004.

Aspholm-Hurtig M, Dailide G, Lahmann M, Kalia A, Ilver D, Roche N, Vikström S, Sjöström R, Lindén S, Bäckström A, Lundberg C, Arnqvist A, Mahdavi J, Nilsson UJ, Velapatiño B, Gilman RH, Gerhard M, Alarcon T, López-Brea M, Nakazawa T, Fox JG, Correa P, Dominguez-Bello MG, Perez-Perez GI, Blaser MJ, Normark S, Carlstedt I, Oscarson S, Teneberg S, Berg DE, Borén T. Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin. Science 305:519-522, 2004.

Whary MT, Fox JG. Th1-mediated pathology in mouse models of human disease is ameliorated by concurrent Th2 responses to parasite antigens. Curr Top Med Chem 4:531-538, 2004.

Hynes SO, Ferris JA, Szponar B, Wadstrom T, Fox JG, O’Rourke J, Lennart L, Yaquian E, Ljungh A, Clyne M, Andersen LP, Moran AP. Comparative chemical and biological characterization of the lipopolysaccharides of gastric and enterohepatic helicobacters. Helicobacter 9:313-323, 2004.

Whary MT, Fox JG. Natural and experimental helicobacter infections. Comp Med 54:128-158, 2004.

Nomura S, Baxter T, Yamaguchi H, Lays C, Vartapetian AB, Fox JG, Lee JR, Wang TC, Goldenring JR. Spasmolytic polypeptide expressing metaplasia to preneoplasia in H. felis infected mice. Gastroenterology 127:582-594, 2004.

Young VB, Knox KA, Cortez JS, Wang W, Mansfield LS, Rogers A, Fox JG, Meek K, Schauer DB. In vitro and in vivo characterization of Helicobacter hepaticus cytolethal distending toxin mutants. Infect Immun 72:2521-2527, 2004.

Stoicov C, Whary M, Rogers AB, Lee FS, Klucevsek K, Li H, Cai X, Saffari R, Ge Z, Khan IA, Combe C, Luster A, Fox JG, Houghton J. Coinfection modulates inflammatory responses and clinical outcome of Helicobacter felis and Toxoplasma gondii infections. J Immunol 173:3329-3336, 2004.

Marini RP, Taylor NS, Lang A, Knox KA, Pena JA, Schauer DB, Fox JG. Characterization of hemolytic Escherichia coli strains in ferrets: recognition of a candidate virulence factor CNF1. J Clin Microbiol 42:5904-5908, 2004.

Gadjeva M, Zhang M, Tomczak M, Wang YY, Dull K, Rogers AB, Erdman S, Fox JG, Carroll M, Horwitz BH. A role for NF-kB subunits p50 and p65 in the inhibition of lipopolysaccharide-induced shock. J Immunol 173:5786-5793, 2004.

Mandell L, Moran AP, Cocchiarella A, Houghton J, Tayler N, Fox JG, Wang TC, Kurt-Jones EA. Intact gram-negative Helicobacter pylori and Helicobacter felis and Helicobacter hepaticus, bacteria activate innate immunity via toll-like receptor-2 but not toll-like receptor 4. Infect Immun 72:6446-6454, 2004.

Boutin SR, Rogers AB, Shen Z, Fry RC, Love JA, Nambiar PR, Suerbaum S, Fox JG. Hepatic temporal gene expression profiling in Helicobacter hepaticus infected A/JCr mice. Toxicol Pathol 32:678-693, 2004.

Rogers AB, Boutin SR, Whary MT, Sundina N, Ge Z, Cormier K, Shen Z, Fox JG. Progression of chronic hepatitis and preneoplasia in Helicobacter hepaticus-infected A/JCr mice. Toxicol Path 32:668-677, 2004.

Houghton J, Stoicov C, Nomura S, Rogers AB, Carlson J, Li H, Cai X, Fox JG, Goldenring JR, Wang TC. Gastric cancer originating from bone marrow derived cells. Science 306:1568-1571, 2004.

Cui G, Koh TJ, Chen D, Zhao C, TAkaishi S, Dockray GJ, Varro A, Rogers AB, Fox JG, Wang TC. Overexpression of glycine-extended gastrin inhibits parietal cell loss and atrophy in the mouse stomach. Cancer Res 64:8160-8166, 2004.

Fox JG, Rogers AB, Whary MT, Taylor NS, Xu S, Feng Y, Keys S. Helicobacter bilis-associated hepatitis in outbred mice. Comp Med 54:571-577, 2004.

Pena JA, Rogers AB, Ge Z, Ng V, Li SY, Fox JG, Versalovic J. Probiotic Lactobacillus spp. diminish Helicobacter hepaticus-induced inflammatory bowel disease in interleukin-10-deficient mice. Infect Immun 73:912-920, 2005.

Niess JH, Brand S, Gu X, Landsman L, Jung S, McCormick BA, Vyas JM, Boes M, Ploegh HL, Fox JG, Littman DR, Reinecker HC. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 307:254-258, 2005.

Maurer KJ, Ihrig MM, Rogers AB, Ng V, Bouchard G, Leonard M, Carey MC, Fox JG. Identification of cholelithogenic enterohepatic Helicobacter species and their role in murine cholesterol gallstone formation. Gastroenterology 128:1023-1033, 2005.

Ge Z, Feng Y, Whary MT, Nambiar P, Xu S, Ng V, Taylor N, Fox JG. Cytolethal distending toxin is essential for Helicobacter hepaticus colonization in outbred Swiss Webster mice. Infect Immun 73:3559-3567, 2005.

Ihrig M, Whary MT, Dangler CA, Fox JG. Gastric helicobacter infection induces a Th2 phenotype but does not elevate serum cholesterol in mice lacking inducible nitric oxide synthase. Infect Immun 73:1664-1670, 2005.

Shen Z, Xu S, Dewhirst FE, Paster BJ, Pena JA, Modlin IM, Kidd M, Fox JG. A novel enterohepatic Helicobacter species “Helicobacter mastomyrinus” isolated from the liver and intestine of rodents. Helicobacter 10:59-70, 2005.

Nambiar PR, Kirchain S, Fox JG. Gastritis-associated adenocarcioma and intestinal metaplasia in a Syrian hamster naturally infected with Helicobacter species. Vet Pathol 42:386-390, 2005.

Robertson BR, O’Rourke JL, Neilan BA, Vandamme P, On SLW, Fox JG, Lee A. Mucispirillum schaedleri gen. nov., sp. nov., a spiral-shaped bacterium colonizing the mucus layer of the gastrointestinal tract of laboratory rodents. Int J Syst Evol Microbiol 55:1199-1204, 2005.

Erdman SE, Sohn JJ, Rao VP, Nambiar PR, Ge Z, Fox JG, Schauer DB. CD4+CD25+ regulatory lymphocytes induce regression of intestinal tumors in ApcMin/+ mice. Cancer Res 65:3998-4004, 2005.

Whary MT, Sundina N, Bravo LE, Correa P, Quinones F, Caro F, Fox JG. Intestinal helminthiasis in Colombian children promotes a Th2 response to Helicobacter pylori: Possible implications for gastric carcinogenesis. Cancer Epidem Biomar Prev 14:1464-1469, 2005.

Bergin IL, Taylor NS, Nambiar PR, Fox JG. Eradication of enteric helicobacters in Mongolian gerbils is complicated by the occurrence of Clostridium difficile enterotoxemia. Comp Med 55:265-268, 2005.

Takaishi S, Cui G, Frederick DM, Carlson JE, Houghton J, Varro A, Dockray GJ, Ge Z, Whary MT, Rogers AB, Fox JG, Wang TC. Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer. Gastroenterology 128:1965-1983, 2005.

Franco AT, Israel DA, Washington MK, Krishna U, Fox JG, Rogers AB, Neish AS, Collier-Hyams L, Perez-Perez GI, Hatakeyama M, Whitehead R, Gaus K, O'Brien DP, Romero-Gallo J, Peek RM. Activation of beta-catenin by carcinogenic Helicobacter pylori. Proc Natl Acad Sci USA 102:10646-10651, 2005.

Fox JG, Obernier J. Veterinarians in biomedical research: A perilous future? J Vet Med Ed 32:301-305, 2005.

Dewhirst FD, Shen Z, Scimeca M, Stokes L, Boumenna T, Chen T, Paster B, Fox JG. Discordant 16S and 23S rRNA phylogenies for the genus Helicobacter: Implications for

Boutin SR, Shen Z, Rogers AB, Feng Y, Ge Z, Xu S, Sterzenbach T, Josenhans C, Schauer DB, Suerbaum S, Fox JG. Different Helicobacter hepaticus strains with variable genomic content induce various degrees of hepatitis. Infect Immun 73:8449-8452, 2005.

Nagamine CM, Jackson C, Beck KA, Marini RP, Fox JG, Nambiar PR. Acute paraplegia in a young adult Long Evans rat resulting from T-cell lymphoma. Contemp Top Lab Anim Med 44:53-56, 2005.

Rogers AB, Taylor NS, Whary MT, Stefanich ED, Wang TC, Fox JG. Helicobacter pylori but not high salt induces gastric intraepithelial neoplasia in B6129 mice. Cancer Res 65:10709-10715, 2005.

Cai X, Stoicov C, Li H, Carlson J, Whary M, Fox JG, Houghton J. Overcoming Fas-mediated apoptosis accelerates Helicobacter-induced gastric cancer in the mouse. Cancer Res 65:10912-10919, 2005.

Crisler-Roberts R, Ge Z, Kearney MT, Singletary KB, Fox JG, Roberts CS, Baker DG. Evaluation of Helicobacter hepaticus bacterial shedding in fostered and sex-segregated C57BL/6 mice. Comp Med 55:515-522, 2005.

Kraft C, Stack A, Josenhans C, Niehus E, Dietrich G, Correa P, Fox JG, Falush D, Suerbaum S. Genomic changes during chronic Helicobacter pylori infection. J Bacteriol 188:249-254, 2006.

Maurer KJ, Rogers AB, Ge Z, Wiese AJ, Carey MC, Fox JG. Helicobacter pylori and cholesterol gallstone formation in C57L/J mice: a prospective study. Am J Physiol Gastr L 290:G175-G182, 2006.

Tomczak MF, Gadjeva M, Wang YY, Brown K, Maroulakou I, Tsichlis PN, Erdman SE, Fox JG, Horwitz BH. Defective activation of ERK in macrophages lacking the p50/p105 subunit of NF-kB is responsible for elevated expression of IL-12 p40 observed after challenge with Helicobacter hepaticus. J Immunol 176:1244-1251, 2006.

Nambiar PR, Kirchain SM, Cormier K, Xu S, Taylor NS, Theve EJ, Patterson MM, Fox JG. Progressive proliferative and dysplastic typhlocolitis in aging Syrian hamsters naturally infected with Helicobacter spp: A spontaneous model of inflammatory bowel disease. Vet Pathol 43:2-14, 2006.

Rao VP, Poutahidis T, Ge Z, Nambiar PR, Horwitz BH, Fox JG, Erdman SE. Proinflammatory CD4+CD45RBhi lymphocytes promote mammary and intestinal carcinogenesis in ApcMin/+ mice. Cancer Res 66:57-61, 2006.

Rogers AB, Cormier KS, Fox JG. Thiol-reactive compounds prevent nonspecific antibody binding in immunohistochemistry. Lab Invest 86:526-533, 2006.

García A, Bosques CJ, Wishnok JS, Feng Y, Karalius BJ, Butterton JR, Schauer DB, Rogers AB, Fox JG. Renal injury is a consistent finding in Dutch Belted rabbits experimentally infected with enterohemorrhagic Escherichia coli. J Infect Dis 193:1125-1134, 2006.

Fox JG, Taylor NS, Howe S, Tidd M, Xu S, Paster BJ, Dewhirst FE. Helicobacter anseris sp. nov. and Helicobacter brantae sp. nov., isolated from feces of resident Canada geese in the greater Boston area. Appl Environ Microb 72:4633-4637, 2006.

Ge Z, Feng Y, Taylor NS, Ohtani M, Polz MF, Schauer DB, Fox JG. Colonization dynamics of altered Schaedler flora is influenced by gender, aging and Helicobacter hepaticus infection in the intestines of Swiss Webster mice. Appl Environ Microb 72:5100-5103, 2006.

Whary MT, Fox JG. Detection, eradication and research implications of Helicobacter infections in laboratory rodents. Lab Animal 35:25-36, 2006.

Rao VP, Poutahidis T, Ge Z, Nambiar PR, Boussahmain C, Wang YY, Horwitz BH, Fox JG, Erdman SE. Innate immune inflammatory response against enteric bacteria Helicobacter hepaticus induces mammary adenocarcinoma in mice. Cancer Res 66:7395-7400, 2006.

Brooks JW, Whary MT, Hattel AL, Shaw DP, Ge Z, Fox JG, Poppenga, RH. Clostridium piliforme infection in two farm-raised white-tailed deer fawns (Odocoileus virginianus) and association with copper toxicosis. Vet Pathol 43:765-768, 2006.

Rao VP, Poutahidis T, Marini RP, Hocolmbe H, Rogers AB, Fox JG. Renal infarction and immune-mediated glomerulonephritis in sheep (Ovis aries) chronically implanted with indwelling catheters. J Am Assoc Lab Anim 45:14-19, 2006.

Garcia A, Xu S, Dehwhirst FE, Nambiar PR, Fox JG. Enterohepatic Helicobacter species isolated from the ileum, liver, and colon of a baboon with pancreatic islet amyloidosis. J Med Microbiol 55:1591-1595, 2006.

Whary MT, Danon SJ, Feng Y, Ge Z, Sundina N, Ng V, Taylor NS, Rogers AB, Fox JG. Rapid onset of ulcerative typhlocolitis in B6.129P2-IL10tm1Cgn (IL-10-/-) mice infected with Helicobacter trogontum is associated with decreased colonization by altered Schaedler’s Flora. Infect Immun 74:6615-6623, 2006.

Tomczak MF, Erdman SE, Davidson A, Wang YY, Nambiar PR, Rogers AB, Rickman BH, Luchetti D, Fox JG, Horwitz BH. Inhibition of Helicobacter hepaticus-induced colitis by IL-10 requires the p50/p105 subunit of NF-ɻB. J Immunol 177:7332-7339, 2006.

Chen ML, Ge Z, Fox JG, Schauer DB. Disruption of tight junctions and induction of proinflammatory cytokine responses in colonic epithelial cells by Campylobacter jejuni. Infect Immun 74:6581-6589, 2006.

Kurt-Jones EA, Cao L, Sandor F, Rogers AB, Whary MT, Nambiar PR, Cerny A, Bowen G, Yan J, Takaishi S, Chi AL, Reed G, Houghton J, Fox JG, Wang TC. Trefoil family factor 2 is expressed in murine gastric and immune cells and controls both gastrointestinal inflammation and systemic immune responses. Infect Immun 75:471-480, 2007.

Fox JG, Wang TC. Inflammation, atrophy, and gastric cancer. (Invited review). J Clin Invest 117:60-69, 2007.

Rao VP, Poutahidis T, Fox JG, Erdman SE. Breast cancer: should gastrointestinal bacteria be on our radar screen? (Invited review). Cancer Res 67:847-850, 2007.

Alyamani EJ, Brandt P, Pena JA, Major AM, Fox JG, Suerbaum S, Versalovic J. Helicobacter hepaticus catalase shares surface predicted epitopes with mammalian catalases. Microbiology 153:1006-1016, 2007.

Borenshtein D, Nambiar PR, Groff EB, Fox JG, Schauer DB. Development of fatal colitis in FVB mice infected with Citrobacter rodentium. Infect Immun 75:3271-3281, 2007.

Lee CW, Rao VP, Rogers AB, Ge Z, Erdman SE, Whary MT, Fox JG. Wild-type and interleukin-10-deficient regulatory T cells reduce effector T-cell-mediated gastroduodenitis in Rag2-/- mice, but only wild-type regulatory T cells suppress Helicobacter pylori gastritis. Infect Immun 75:2699-2707, 2007.

Fox JG. Helicobacter bilis: bacterial provocateur orchestrates host immune responses to commensal flora in a model of inflammatory bowel disease. Gut 56:898-900, 2007.

Taylor NS, Xu S, Nambiar P, Dewhirst FE, Fox JG. Enterohepatic Helicobacter species are prevalent in mice from commercial and academic institutions in Asia, Europe, and North America. J Clin Microbiol 45:2166-2172, 2007.

Ge Z, Rogers AB, Feng Y, Lee A, Xu S, Taylor NS, Fox JG. Bacterial cytolethal distending toxin promotes the development of dysplasia in a model of microbially induced hepatocarcinogenesis. Cell Microbiol 9:2070-2080, 2007.

Sterzenbach T, Lee SK, Brenneke B, von Goetz F, Schauer D, Fox JG, Suerbaum S, Josenhans C. Inhibitory effect of enterohepatic Helicobacter hepaticus on innate immune responses of mouse intestinal epithelial cells. Infect Immun 75:2717-2728, 2007.

Maurer KJ, Rao VP, Ge Z, Rogers AB, Oura TJ, Carey MC, Fox JG. T cell function is critical for murine cholesterol gallstone formation. Gastroenterology 133:1304-1315, 2007.

Denno DM, Klein EJ, Young VB, Fox JG, Wang D, Tarr PI. Explaining unexplained diarrhea and associating risks and infections. Animal Health Res Rev 8:69-80, 2007.

Stenstrom B, Zhao CM, Rogers AB, Nilsson HO, Sturegard E, Lundgren S, Fox JG, Wang TC, Wadstrom TM, Chen D. Swedish moist snuff accelerates gastric cancer development in Helicobacter pylori-infected wild-type and gastrin transgenic mice. Carcinogenesis 28:2041-2046, 2007.

Ohtani M, Garcia A, Rogers AB, Ge Z, Taylor NS, Xu S, Watanabe K, Marini RP, Whary MT, Wang TC, Fox JG. Protective role of 17É¿-estradiol against the development of Helicobacter pylori-induced gastric cancer in INS-GAS mice. Carcinogenesis 28:2597-2604, 2007.

Fox JG, Rogers AB, Whary MT, Ge Z, Ohtani M, Jones EK, Wang TC. Accelerated progression of gastritis to dysplasia in the pyloric antrum of TFF2-/- C57BL6 x Sv129 Helicobacter pylori-infected mice. Am J Pathol 171:1520-1528, 2007.

Rogers AB, Theve EJ, Feng Y, Fry RC, Taghizadeh K, Clapp KM, Boussahmain C, Cormier KS, Fox JG. Hepatocellular carcinoma associated with liver-gender disruption in male mice. Cancer Res 67:11536-11546, 2007.

Fox JG, Boutin SR, Handt LK, Taylor NS, Xu S, Rickman BH, Marini RP, Dewhirst FE, Paster BJ, Motzel S, Klein HJ. Isolation and characterization of a novel Helicobacter species, “Helicobacter macacae,” from rhesus monkeys with and without chronic idiopathic colitis. J Clin Microbiol 45:4061-4063, 2007.

Poutahidis T, Haigis KM, Rao VP, Nambiar PR, Taylor CL, Ge Z, Watanabe K, Davidson A, Horwitz BH, Fox JG, Erdman SE. Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma. Carcinogenesis 28:2614-2623, 2007.

Lee CW, Wang XD, Chien KL, Ge Z, Rickman BH, Rogers AB, Varro A, Whary MT, Wang TC, Fox JG. Vitamin C supplementation does not protect L-gulono-É¡-lactone oxidase-deficient mice from Helicobacter pylori-induced gastritis and gastric premalignancy. Int J Cancer 122:1068-1076, 2008.

Nagamine CM, Rogers AB, Fox JG, Schauer DB. Helicobacter hepaticus promotes azoxymethane-initiated colon tumorigenesis in BALB/c-IL10-deficient mice. Int J Cancer 122:832-838, 2008.

García A, Ihrig MM, Fry RC, Feng Y, Xu S, Boutin SR, Rogers AB, Muthupalani S, Samson LD, Fox JG. Genetic susceptibility to chronic hepatitis is inherited codominantly in Helicobacter hepaticus-infected AB6F1 and B6AF1 hybrid male mice and progression to hepatocellular carcinoma is linked to hepatic expression of lipogenic genes and immune function-associated networks. Infect Immun 76:1866-1876, 2008.

Lee CW, Rickman BH, Rogers AB, Ge Z, Wang TC, Fox JG. Helicobacter pylori eradication prevents progression of gastric cancer in hypergastrinemic INS-GAS mice. Cancer Res 68:3540-3548, 2008.

Jackson CN, Rogers AB, Maurer K, Lofgren J, Fox JG, Marini RP. Cystic renal disease in the domestic ferret. Comparative Med 58:161-167, 2008.

Kishimoto TK, Viswanathan K, Ganguly T, Elankumaran S, Smith S, Pelzer K, Lansing J, Sriranganathan N, Zhao G, Galcheva-Gargova Z, Al-Hakim A, Bailey S, Fraser B, Roy S, Rogers-Cotrone T, Buhse L, Whary MT, Fox JG, Nasr M, Dal Pan GJ, Shriver Z, Langer RS, Venkataraman G, Austen KF, Woodcock J, Sasisekharan R. Contaminated heparin associated with adverse clinical events activates the contact system. N Engl J Med 358:2457-2467, 2008.

Nagamine CM, Sohn JJ, Rickman BH, Rogers AB, Fox JG, Schauer DB. Helicobacter hepaticus infection promotes colon tumorigenesis in the BALB/c Rag2-/- ApcMin/+ mouse. Infect Immun 76:2758-2766, 2008.

Wang Y, Rickman BH, Poutahidis T, Schlieper K, Jackson EA, Erdman SE, Fox JG, Horwitz BH. c-Rel is essential for the development of innate and T cell-induced colitis. J Immunol 180:8118-8125, 2008.

Lemke L, Dronen N, Fox JG, Nambiar PR. Infestation of wild-caught American bullfrogs (Rana catesbeiana) by multiple species of metazoan parasites. J Am Assoc Lab Anim Sci 47:42-46, 2008.

Bridgeford EC, Fox JG, Nambiar PR, Rogers AB. Agammaglobulinemia and Staphylococcus aureus botryomycosis in a cohort of related sentinel Swiss Webster mice. J Clin Microbiol 46:1881-1884, 2008.

Ge Z, Lee A, Whary MT, Rogers AB, Maurer KJ, Taylor NS, Schauer DB, Fox JG. Helicobacter hepaticus urease is not required for intestinal colonization but promotes hepatic inflammation in male A/JCr mice. Microb Pathogenesis 45:18-24, 2008.

García A, Marini RP, Catalfamo JL, Knox KA, Schauer DB, Rogers AB, Fox JG. Intravenous Shiga toxin 2 promotes enteritis and renal injury characterized by polymorphonuclear leukocyte infiltration and thrombosis in Dutch Belted rabbits. Microbes Infect 10:650-656, 2008.

Bridgeford EC, Marini RP, Feng Y, Parry NMA, Rickman B, Fox JG. Gastric Helicobacter species as a cause of feline gastric lymphoma: A viable hypothesis. Vet Immunol Immunop 123:106-113, 2008.

Ge Z, Schauer DB, Fox JG. In vivo virulence properties of bacterial cytolethal distending toxin. Cell Microbiol 10:1599-1607, 2008.

Ge Z, Sterzenbach T, Whary M, Rickman BH, Rogers A, Shen Z, Taylor NS, Schauer DB, Josenhans C, Suerbaum S, Fox JG. Helicobacter hepaticus HHGI1 is a pathogenicity island associated with typhlocolitis in B6.129-IL10tm1Cgn mice. Microbes Infect 10:726-733, 2008.

Meira LB, Bugni JM, Green SL, Lee CW, Pang B, Borenshtein D, Rickman BH, Rogers AB, Moroski CA, McFaline JL, Schauer DB, Dedon PC, Fox JG, Samson LD. DNA damage induced by chronic inflammation is a major contributor to carcinogenesis. J Clin Invest 118:2516-2525, 2008.

Fremont JJ, Marini RP, Fox JG, Rogers AB. Acute respiratory distress syndrome (ARDS) in two Rhesus macaques (Mucaca mulata). J Am Assoc Lab Anim 47:61-66, 2008.

Theve EJ, Feng Y, Taghizadeh K, Cormier KS, Bell DR, Fox JG, Rogers AB. Sex hormone influence on hepatitis in young male mice infected with Helicobacter hepaticus. Infect Immun 76:4071-4078, 2008.

Pisani P, Whary MT, Nilsson I, Sriamporn S, Wadström T, Fox JG, Ljungh A, Forman D. Cross-reactivity in immune responses to Helicobacter bilis and Helicobacter pylori in a Thai population at high risk for cholangiocarcinoma. Clin Vaccine Immunol 15: 1363-1368, 2008.

Lemke L, Rogers AB, Nambiar PR, Fox JG. Obesity and noninsulin dependent diabetes mellitus in Swiss Webster mice associated with late-onset hepatocellular carcinoma. J Endocrinol 199:21-32, 2008.

Sterzenbach T, Bartonickova L, Behrens W, Brenneke B, Schulze J, Kops F, Chin EY, Katzowitsch E, Schauer DB, Fox JG, Suerbaum S, Josenhans C. Role of the Helicobacter hepaticus flagellar sigma factor FliA in gene regulation and murine colonization. J Bacteriol 190:6398-6408, 2008.

Shuiping T, Takaishi S, Bhagat G, Kurt-Jones EA, Rickman BH, Smirnova I, Betz K, Penz-Oesterreicher, Bjorkdahl O, Fox JG, Wang TC. Overexpression of interleukin -1b induces gastric inflammation and promotes carcinogenesis in transgenic mice. Cancer Cell 14:408-419, 2008.

McBee, ME, Zheng, PZ, Rogers, AB, Fox, JG, Schauer, DB. Modulation of Acute Diarrheal Illness by Persistent Bacterial Infection.Infect and Immun 76: 4851-4858. 2008.

Hagen SJ, Yang DX, Taylor NS, Tashima K, Fox JG. Epithelial cell expression of BCL-2 family proteins predicts mechanisms that regulate Helicobacter pylori-induced pathology in the mouse stomach. Lab Invest 88: 1227-1244, 2008.

Watanabe K, Rao VP, Poutahidis T, Rickman BH, Ohtani M, Xu S, Rogers AB, Ge Z, Horwitz BH, Fujioka T, Erdman SE, Fox JG. CLTA-4 blockade abrogates protection by regulatory T cells in a mouse model of microbially-induced colitis. Infect Immun 76:5834-5842, 2008.

Borenshtein D, Fry RC, Groff EB, Nambiar PR, Carey VJ, Fox JG, Schauer DB. Diarrhea as a cause of mortality in a mouse model of infectious colitis. Genome Biology. 9: R122, 2008.

Erdman SE, Rao VP, Poutahidis T, Rogers AB, Taylor CL, Jackson EA, Ge Z, Lee CW, Schauer DB, Wogan GN, Tannenbaum SR, Fox JG. Nitric oxide and TNF-alpha trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient mice. Proc Natl Acad Sci U S A.106(4):1027-32, 2009.

Hagen SJ, Ohtani M, Zhou J, Taylor, NS, Rickman B, Blackburn GL, Fox JG. Inflammation and Foveolar Hyperplasia Are Reduced by Supplemental Dieraty Glutamine during Helicobacter pylori Infection in Mice. J. Nutition. 2009. 139(5): 912- 918.

Maurer KJ, Carey MC, Fox JG. The role of inflammation and the immune system in cholesterol gallstone formation. Gastroenterology. 2009. 136: 425-440.

Hurcombe SDA, Fox JG, and Kohn CW. Isolation of Campylobacter fetus subspecies fetus in a two-year-old Quarterhorse with chronic diarrhea of an undetermined etiology. J Vet Diag. Investigation. 2009. 21:266-269.

Fox JG. Helicobacter hepaticus and hepatic disease. Japanese Journal of Helicobacter Research. 2009. 10: 5-7.

Lemke LB, Whary MT, Ge Z, Feng Y, Rogers AB, Muthupalani S, Fox JG. Concurrent Helicobacter bilis infection in C57BL/6 mice reduces pro-inflammatory immune responses and attenuates gastric pathology associated with H. pylori infection. Inf & Imm. 2009. 77: 2147-2158.

Buss DD, Atchison ML, Corps KN, Falkowski LB, Fox JG, Hendricks JC, Mexas A, Rosol TJ, Stromberg BE. Veterinarians in Biomedical Research: Building National Capacity. J Vet Med Educ. 2009. 36: 62-69.

Shen Z, Feng Y, Rogers AB, Rickman BH, Whary MT, Xu S, Clapp KM, Miyamae JA, Boutin SR, Fox JG. Cytolethal distending toxin promotes Helicobacter cinaedi-associated typhlocolitis in IL-10 deficient mice. Infect Immun. 2009. 77: 2508-16.


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