Darrell J. Irvine, Ph.D.
Eugene Bell Associate Professor of Tissue Engineering

Research group web site

Email: djirvine@mit.edu
Office: 8-425
Phone: (617) 452-4174
Administrative Assistant: Jazy Ma

Courses: BEH.340J, BEH.462J, 3.012

Selected Publications

Click here for complete publication listing.

1. “The Use of Graft Copolymers to Bind Immiscible Blends,” D. Gersappe, D. Irvine, A.C. Balazs, Y. Liu, J. Sokolov, M. Rafailovich, S. Schwarz, and D.G. Peiffer, Science, 265(5175) 1072-1074 (1994).

2. “Self-Consistent Field Analysis of Grafted Star Polymers,” D.J. Irvine, A.M. Mayes, and L. Griffith-Cima, Macromolecules, 29(18) 6037-6043 (1996). [Abstract] [PDF]

3. “Comparison of Tethered Star and Linear Poly(Ethylene Oxide) for Control of Biomaterials Surface Properties,” D.J. Irvine, A.M. Mayes, S.K. Satija, J.G. Barker, S.J. Sofia-Allgor, and L.G. Griffith, Journal of Biomedical Materials Research, 40(3) 498-509 (1998).

4. "Polymer Colloids for Cell-Resistant or Cell-Interactive Surfaces," P. Banerjee, D.J. Irvine, A.M. Mayes, and L.G. Griffith, J. Biomed. Mater. Res., 50(3) 331-339 (2000).

5. “Nanoscale Clustering of RGD Peptides at Surfaces Using Comb Polymers. 2. Surface Segregation of Comb Polymers in Polylactide,” D.J. Irvine, A.-V. Ruzette, A.M. Mayes, and L.G. Griffith, Biomacromolecules, 2(2) 545-556 (2001). [Abstract] [PDF]

6. “Nanoscale Clustering of RGD Peptides at Surfaces Using Comb Polymers. 1. Synthesis and Characterization of Comb Thin Films,” D.J. Irvine, A.M. Mayes, and L.G. Griffith, Biomacromolecules 2(1) 85-94 (2001). [Abstract] [PDF]

7. “Simulations of Cell-Surface Integrin Binding to Nanoscale-Clustered Adhesion Ligands,” D.J. Irvine, K.-A. Hue, A.M. Mayes, and L.G. Griffith, Biophys. J. 82, 120-132 (2002). [Abstract] [PDF]

8. “Control of cell adhesion by nanoscale RGD organization and mechanical stimulus,” L.Y. Koo, D.J. Irvine, A.M. Mayes, D.A. Lauffenburger, and L.G. Griffith, J. Cell. Sci. 115(7), 1423-1433 (2002).

9. “Rapid signaling-induced receptor reorientation in the formation of the immunological synapse,” W. Moss, D.J. Irvine, M. Krummel, and M.M. Davis, Proc. Natl. Acad. Sci. USA 99, 15024-15029 (2002). [Abstract] [PDF]

10. “Direct observation of ligand recognition by T cells,” D.J. Irvine, M.A. Purbhoo, M. Krogsgaard, and M.M. Davis, Nature 419(6909), 845-849 (2002). [Abstract] [PDF]

11. "Dynamics of cell surface molecules during T cell recognition," M.M.Davis, M. Krogsgaard, J.B.Huppa, C. Suman, M.A. Purbhoo, D.J. Irvine, L.C. Wu, and L. Ehrlich, Annual Review of Biochemistry , 72 712-742 (2003). [Abstract] [PDF]

12. "Direct cell migration via chemoattractants released from degradable microspheres," X. Zhao, S. Jain, B. Larman, S. Gonzalez, and D.J. Irvine, Biomaterials (in press)

13. "A role for the immunological synapse in lineage commitment of CD4 lymphocytes," R.A. Maldonado, D.J. Irvine, R. Schreiber, and L.H. Glimcher, Nature 431 527-532 (2004). [Abstract] [PDF}

14. "Bioactive hydrogels with an ordered cellular structure combine interconnected macroporosity and robust mechanical properties," A.N. Stachowiak, A. Bershteyn, and D.J. Irvine, Adv. Mater. (in press).

15. "Photogenerated polyelectrolyte bilayers from an aqueous-processible photoresist for multiple protein patterning," J. Doh, and D.J. Irvine, J. Am. Chem. Soc., 126 (30) 9170-9171 (2004). [Abstract] [PDF]

16. "T cell killing does not require the formation of a stable mature immunological synapse," M.A. Purbhoo, D.J. Irvine, J.B. Huppa , and M.M. Davis, Nature Immunology , 5 524-530 (2004). [Abstract] [PDF]

17. "Large Area Two-Dimensional B Cell Arrays for Sensing and Cell-Sorting Applications," H. Kim, J. Doh, D.J. Irvine, R.E. Cohen, and P.T. Hammond, Biomacromolecules , 5 822-827 (2004). [Abstract] [PDF]

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