Research Focus

A variety of projects are available in the general area of biomedical fluid dynamics and solid mechanics. While the projects are typically motivated by a biological or physiological problem, they may be appropriate for anyone having an interest in either mechanical or biomedical engineering. Most projects involve a blend of experiment, theory and numerical analysis. Opportunities exist for research at all levels: S.B., S.M., and Ph.D.

Cell Mechanics and Mechanotransduction
The goal of these studies is to develop a fundamental understanding of the mechanism by which externally applied forces affect and guide cell function. Models of single cell manipulations by optical and magnetic traps are developed to predict the distribution of stress and strain within the cell membrane and cytoskeleton. Experiments are underway to visualize the biological response in terms of calcium transients, actin polymerization, and gene expression. Results from these studies will have implications to various diseases such as atherosclerosis and arthritis, and could be used to help develop methods for promoting cell growth over artificial surfaces.

Development of a New Oligopeptide Biomaterial for Tissue Engineering
In collaboration with faculty members from the biology and chemical engineering departments, we have developed a new biomaterial derived from a class of ionic self-complementary oligopeptides. These short peptides self-assemble in aqueous salt solution into 3-dimensional matrices capable of favorable interactions with cells, and offer promise for useful design based on rational changes in sequence, for use in the development of engineered tissue implants. We investigate the mechanical properties of this material, combining experimental and theoretical approaches. Parameters of interest include the static elastic modulus and fracture strength. The material microstructure is examined by atomic force microscopy and scanning electron microscopy and simulated using molecular dynamics and continuum models. These results provide guidance for the improvement of the mechanical properties of these new materials. Applications are also being pursued in the development of vascularized engineered tissues.

Mechanics and biology of the vulnerable plaque
The progression of arterial disease often involves the adhesion of monocytes to the endothelial surface, the migration of these into the vessel wall, and the degradation of the wall tissues ultimately leading to fracture of the wall, thrombus formation (clotting) and a further narrowing of the vessel lumen. This project seeks to establish the relationship between fluid dynamic shear stress and monocyte adhesion, on one hand, and tissue-borne stresses and monocyte production of tissue-degrading enzymes (matrix metalloproteinases, MMP) on the other. Images of the carotid bifurcation will be generated by MRI, and numerical methods will be used to analyze the flow and vessel wall deformations. These results will be correlated with histological measures of monocyte adhesion and MMP synthesis.

Publications

1976-1980 | 1981-1990 | 1991-2000 | 2001-

Kamm, R. and A. H. Shapiro (1976). "Hemodynamics of external pneumatic compression. pp. 125-9." In: Madden JL, Hume M, ed. Venous thromboembolism. New York, Appleton- Century-Crofts.

Kamm, R. D. (1976). "Detection of Weakly Absorbing Gases Using a Resonant Optoacoustic Method." Journal of Applied Physics 47(8): 3550-3558.

Kamm, R. D. and A. H. Shapiro (1979). "Unsteady-Flow in a Collapsible Tube Subjected to External-Pressure or Body Forces." Journal of Fluid Mechanics 95(NOV): 1-78.

Slutsky, A. S., F. M. Drazen, et al. (1980). "Effective pulmonary ventilation with small-volume oscillations at high frequency." Science 209(4456): 609-71.

Thirsk, R. B., R. D. Kamm, et al. (1980). "Changes in venous blood volume produced by external compression of the lower leg." Med Biol Eng Comput 18(5): 650-6.

Kececioglu, I., M. E. McClurken, et al. (1981). "Steady, Supercritical-Flow in Collapsible Tubes .1. Experimental-Observations." Journal of Fluid Mechanics 109(AUG): 367-389.

Lueptow, R. M., J. M. Karlen, et al. (1981). "Circulatory model studies of external cardiac assist by counterpulsation." Cardiovasc Res 15(8): 443-55.

Lueptow, R. M., J. M. Karlen, et al. (1981). "Study of four modes of counterpulsative external cardiac assist." Trans Am Soc Artif Intern Organs 27: 576-81.

McClurken, M. E., I. Kececioglu, et al. (1981). "Steady, Supercritical-Flow in Collapsible Tubes .2. Theoretical-Studies." Journal of Fluid Mechanics 109(AUG): 391-415.

Rossing, T. H., A. S. Slutsky, et al. (1981). "Tidal volume and frequency dependence of carbon dioxide elimination by high-frequency ventilation." N Engl J Med 305(23): 1375-9.

Slutsky, A. S., R. D. Kamm, et al. (1981). "Effects of frequency, tidal volume, and lung volume on CO2 elimination in dogs by high frequency (2-30 Hz), low tidal volume ventilation." J Clin Invest 68(6): 1475-84.

Kamm, R. D. (1982). "Bioengineering studies of periodic external compression as prophylaxis against deep vein thrombosis-part I: numerical studies." J Biomech Eng 104(2): 87-95.

Olson, D. A., R. D. Kamm, et al. (1982). "Bioengineering studies of periodic external compression as prophylaxis against deep vein thrombosis-part II: experimental studies on a stimulated leg." J Biomech Eng 104(2): 96-104.

Rossing, T. H., A. S. Slutsky, et al. (1982). "CO2 elimination by high-frequency oscillations in dogs--effects of histamine infusion." J Appl Physiol 53(5): 1256-62.

Jan, D. L., R. D. Kamm, et al. (1983). "Filling of partially collapsed compliant tubes." J Biomech Eng 105(1): 12-9.

Johnson, M. C. and R. D. Kamm (1983). "The role of Schlemm's canal in aqueous outflow from the human eye." Invest Ophthalmol Vis Sci 24(3): 320-5.

Joshi, C. H., R. D. Kamm, et al. (1983). "An Experimental-Study of Gas-Exchange in Laminar Oscillatory Flow." Journal of Fluid Mechanics 133(AUG): 245-254.

Slutsky, A. S., R. D. Kamm, et al. (1983). "High frequency oscillatory ventilation using tidal volumes smaller than the anatomical dead space." Int Anesthesiol Clin 21(3): 161-81.

Akhavan, R. and R. D. Kamm (1984). "Pressure excursions during oscillatory flow in a branching network of tubes." J Appl Physiol 57(3): 665-73.

Battaglioli, J. L. and R. D. Kamm (1984). "Measurements of the compressive properties of scleral tissue." Invest Ophthalmol Vis Sci 25(1): 59-65.

Drazen, J. M., R. D. Kamm, et al. (1984). "High-frequency ventilation." Physiol Rev 64(2): 505-43.

Kamm, R. D., J. Collins, et al. (1984). "Gas transport during oscillatory flow in a network of branching tubes." J Biomech Eng 106(4): 315-20.

Kamm, R. D., A. S. Stutsky, et al. (1984). "High-frequency ventilation." Crit Rev Biomed Eng 9(4): 347-79.

Khoo, M. C., A. S. Slutsky, et al. (1984). "Gas mixing during high-frequency ventilation: an improved model." J Appl Physiol 57(2): 493-506.

Solway, J., N. Gavriely, et al. (1984). "Intra-airway gas mixing during high-frequency ventilation." J Appl Physiol 56(2): 343-54.

Kamm, R. D. (1985). "Measurements of Lip Pressure Exerted on a Cigarette During Normal Smoking." Behavior Research Methods Instruments & Computers 17(3): 379-384.

Venegas, J. G., J. Custer, et al. (1985). "Relationship for gas transport during high-frequency ventilation in dogs." J Appl Physiol 59(5): 1539-47.

Drazen, J. M., I. Dreshaij, et al. (1986). "CO2 elimination by high-frequency oscillation: effects of vagosympathetic stimulation." J Appl Physiol 61(5): 1836-42.

Ethier, C. R., R. D. Kamm, et al. (1986). "Calculations of flow resistance in the juxtacanalicular meshwork." Invest Ophthalmol Vis Sci 27(12): 1741-50.

Johnson, M., C. R. Ethier, et al. (1986). "The flow of aqueous humor through micro-porous filters." Invest Ophthalmol Vis Sci 27(1): 92-7.

Johnson, M. and R. D. Kamm (1986). "Numerical-Studies of Steady Flow Dispersion at Low Dean Number in a Gently Curving Tube." Journal of Fluid Mechanics 172: 329-345.

Kamm, R., R. Butcher, et al. (1986). "Optimisation of indices of external pneumatic compression for prophylaxis against deep vein thrombosis: radionuclide gated imaging studies." Cardiovasc Res 20(8): 588-96.

Kamm, R. D., E. T. Bullister, et al. (1986). "The effect of a turbulent jet on gas transport during oscillatory flow." J Biomech Eng 108(3): 266-72.

Watson, J. W., D. R. Burwen, et al. (1986). "Effect of flow rate on blood gases during constant flow ventilation in dogs." Am Rev Respir Dis 133(4): 626-9.

Elad, D., R. D. Kamm, et al. (1987). "Choking phenomena in a lung-like model." J Biomech Eng 109(1): 1-9.

Elad, D., R. D. Kamm, et al. (1987). "Choking Phenomena in a Lung-Like Model." Journal of Biomechanical Engineering-Transactions of the Asme 109(1): 1-9.

Johnson, M., R. Kamm, et al. (1987). "Scaling Laws and the Effects of Concentration Polarization on the Permeability of Hyaluronic-Acid." Physicochemical Hydrodynamics 9(3-4): 427-441.

Kimmel, E., R. D. Kamm, et al. (1987). "A cellular model of lung elasticity." J Biomech Eng 109(2): 126-31.

Paloski, W. H., R. B. Slosberg, et al. (1987). "Effects of gas properties and waveform asymmetry on gas transport in a branching tube network." J Appl Physiol 62(3): 892-901.

Salzman, E. W., G. P. McManama, et al. (1987). "Effect of optimization of hemodynamics on fibrinolytic activity and antithrombotic efficacy of external pneumatic calf compression." Ann Surg 206(5): 636-41.

Watson, J., R. D. Kamm, et al. (1987). "Gas exchange during constant flow ventilation with different gases." Am Rev Respir Dis 136(2): 420-5.

Elad, D., R. D. Kamm, et al. (1988). "Tube law for the intrapulmonary airway." J Appl Physiol 65(1): 7-13.

Elad, D., R. D. Kamm, et al. (1988). "Mathematical simulation of forced expiration." J Appl Physiol 65(1): 14-25.

Ingenito, E., R. D. Kamm, et al. (1988). "A model of constant-flow ventilation in a dog lung." J Appl Physiol 64(5): 2150-9.

Kimmel, E., R. D. Kamm, et al. (1988). "Numerical solutions for steady and unsteady flow in a model of the pulmonary airways." J Biomech Eng 110(4): 292-9.

Pedley, T. J. and R. D. Kamm (1988). "The Effect of Secondary Motion on Axial Transport in Oscillatory Tube Flow." Journal of Fluid Mechanics 193: 347-367.

Elad, D. and R. D. Kamm (1989). "Parametric evaluation of forced expiration using a numerical model." J Biomech Eng 111(3): 192-9.

Elad, D., R. D. Kamm, et al. (1989). "Steady Compressible Flow in Collapsible Tubes - Application to Forced Expiration." Journal of Fluid Mechanics 203: 401-418.

Ethier, C. R., R. D. Kamm, et al. (1989). "Further studies on the flow of aqueous humor through microporous filters." Invest Ophthalmol Vis Sci 30(4): 739-46.

Ethier, C. R. and R. D. Kamm (1989). "Mass-Transfer During Rate-Limited Langmuir Adsorption in a Pore." Physicochemical Hydrodynamics 11(2): 205-217.

Ethier, C. R. and R. D. Kamm (1989). "Flow through Partially Gel-Filled Channels." Physicochemical Hydrodynamics 11(2): 219-227.

Ethier, C. R. and R. D. Kamm (1989). "The Hydrodynamic Resistance of Filter Cakes." Journal of Membrane Science 43(1): 19-30.

Ethier, C. R., R. D. Kamm, et al. (1989). "Further-Studies on the Flow of Aqueous-Humor through Microporous Filters." Investigative Ophthalmology & Visual Science 30(4): 739-746.

Jan, D. L., A. H. Shapiro, et al. (1989). "Some features of oscillatory flow in a model bifurcation." J Appl Physiol 67(1): 147-59.

Kamm, R. D. and T. J. Pedley (1989). "Flow in collapsible tubes: a brief review." J Biomech Eng 111(3): 177-9.

Kamm, R. D. and R. C. Schroter (1989). "Is airway closure caused by a liquid film instability?" Respir Physiol 75(2): 141-56.

Kamm, R. D. (1989). "Toward improved methods of high frequency ventilation: a study of gas transport mechanisms." Acta Anaesthesiol Scand Suppl 90: 51-7.

Barsotti, M. F., S. P. Bartels, et al. (1990). "Background-protein effects on fluorophotometric data." Invest Ophthalmol Vis Sci 31(10): 2046-50.

Freddo, T. F., S. P. Bartels, et al. (1990). "The source of proteins in the aqueous humor of the normal rabbit." Invest Ophthalmol Vis Sci 31(1): 125-37.

Johnson, M., D. H. Johnson, et al. (1990). "The filtration characteristics of the aqueous outflow system." Exp Eye Res 50(4): 407-18.

Tsuda, A., B. J. Savilonis, et al. (1990). "Periodic flow at airway bifurcations. III. Energy dissipation." J Appl Physiol 69(2): 562-9.

Tsuda, A., R. Kamm, et al. (1990). "Periodic flow at airway bifurcations. II. Flow partitioning." J Appl Physiol 69(2): 553-61.

Tsuzaki, K. and R. D. Kamm (1990). "Flow distribution in a single bifurcation during high-frequency oscillation." Respir Physiol 82(1): 89-105.

Tsuzaki, K. and R. D. Kamm (1990). "Flow Distribution in a Single Bifurcation During High-Frequency Oscillation." Respiration Physiology 82(1): 89-106.

Akhavan, R., R. D. Kamm, et al. (1991). "An Investigation of Transition to Turbulence in Bounded Oscillatory Stokes Flows .1. Experiments." Journal of Fluid Mechanics 225: 395-422.

Akhavan, R., R. D. Kamm, et al. (1991). "An Investigation of Transition to Turbulence in Bounded Oscillatory Stokes Flows .2. Numerical Simulations." Journal of Fluid Mechanics 225: 423-444.

Johnson, M., A. Chen, et al. (1991). "The pressure and volume dependence of the rate of wash-out in the bovine eye." Curr Eye Res 10(4): 373-5.

Johnson, M., R. D. Kamm, et al. (1991). "The Nonlinear Growth of Surface-Tension-Driven Instabilities of a Thin Annular Film." Journal of Fluid Mechanics 233: 141-156.

Kim, A., C. H. Wang, et al. (1991). "The specific hydraulic conductivity of bovine serum albumin [published errata appear in Biorheology 1992 Mar-Jun;29(2-3):379 and 1993 Sep- Dec;30(5-6):473]." Biorheology 28(5): 401-19.

Kim, A., C. H. Wang, et al. (1991). "The Specific Hydraulic Conductivity of Bovine Serum-Albumin." Biorheology 28(5): 401-419.

Lee, R. T., A. J. Grodzinsky, et al. (1991). "Structure-dependent dynamic mechanical behavior of fibrous caps from human atherosclerotic plaques." Circulation 83(5): 1764-70.

Loree, H. M., R. D. Kamm, et al. (1991). "Turbulent pressure fluctuations on surface of model vascular stenoses." Am J Physiol 261(3 Pt 2): H644-50.

Sharp, M. K., R. D. Kamm, et al. (1991). "Dispersion in a Curved Tube During Oscillatory Flow." Journal of Fluid Mechanics 223: 537-563.

Barsotti, M. F., S. P. Bartels, et al. (1992). "The source of protein in the aqueous humor of the normal monkey eye." Invest Ophthalmol Vis Sci 33(3): 581-95.

Freddo, T. F., S. P. Bartels, et al. (1992). "Morphologic correlations with fluorophotometric data from monkey eyes with anterior uveitis." Invest Ophthalmol Vis Sci 33(5): 1642-9.

Johnson, M., A. Shapiro, et al. (1992). "Modulation of outflow resistance by the pores of the inner wall endothelium." Invest Ophthalmol Vis Sci 33(5): 1670-5.

Kamm, R. D. and J. M. Drazen (1992). "Airway hyperresponsiveness and airway wall thickening in asthma. A quantitative approach [editorial; comment]." Am Rev Respir Dis 145(6): 1249-50.

Loree, H. M., R. D. Kamm, et al. (1992). "Effects of fibrous cap thickness on peak circumferential stress in model atherosclerotic vessels." Circ Res 71(4): 850-8.

Cheng, G. C., H. M. Loree, et al. (1993). "Distribution of circumferential stress in ruptured and stable atherosclerotic lesions. A structural analysis with histopathological correlation." Circulation 87(4): 1179-87.

Collins, J. M., A. H. Shapiro, et al. (1993). "The steady expiratory pressure-flow relation in a model pulmonary bifurcation." J Biomech Eng 115(3): 299-305.

Espinosa, F. F., A. H. Shapiro, et al. (1993). "Spreading of exogenous surfactant in an airway." J Appl Physiol 75(5): 2028-39.

Johnson, M., H. Gong, et al. (1993). "Serum proteins and aqueous outflow resistance in bovine eyes." Invest Ophthalmol Vis Sci 34(13): 3549-57.

Otis, D. R., Jr., M. Johnson, et al. (1993). "Role of pulmonary surfactant in airway closure: a computational study." J Appl Physiol 75(3): 1323-33.

Lee, R. T. and R. D. Kamm (1994). "Vascular mechanics for the cardiologist." J Am Coll Cardiol 23(6): 1289-95.

Loree, H. M., B. J. Tobias, et al. (1994). "Mechanical properties of model atherosclerotic lesion lipid pools." Arterioscler Thromb 14(2): 230-4.

Otis, D. R., Jr., E. P. Ingenito, et al. (1994). "Dynamic surface tension of surfactant TA: experiments and theory." J Appl Physiol 77(6): 2681-8.

Pedley, T. J., P. Corieri, et al. (1994). "Gas flow and mixing in the airways." Crit Care Med 22(9 Suppl): S24-36.

Yager, D., T. Cloutier, et al. (1994). "Airway surface liquid thickness as a function of lung volume in small airways of the guinea pig." J Appl Physiol 77(5): 2333-40.

Freddo, T. F., R. D. Kamm, et al. (1995). "Pathway of albumin into the anterior chamber [letter; comment]." Graefes Arch Clin Exp Ophthalmol 233(10): 662-5.

Freddo, T. F., R. D. Kamm, et al. (1995). "Pathway of Albumin into the Anterior-Chamber." Graefes Archive for Clinical and Experimental Ophthalmology 233(10): 662-663.

Kamm, R. D. (1995). "Shear-augmented dispersion in the respiratory system." Symp Soc Exp Biol 49: 277-95.

Yager, D., R. D. Kamm, et al. (1995). "Airway wall liquid. Sources and role as an amplifier of bronchoconstriction." Chest 107(3 Suppl): 105S-110S.

Otis, D. R., Jr., F. Petak, et al. (1996). "Airway closure and reopening assessed by the alveolar capsule oscillation technique." J Appl Physiol 80(6): 2077-84.

Yager, D., M. A. Martins, et al. (1996). "Acute histamine-induced flux of airway liquid: role of neuropeptides." J Appl Physiol 80(4): 1285-95.

Dhadwal, A., B. Wiggs, et al. (1997). "Effects of anatomic variability on blood flow and pressure gradients in the pulmonary capillaries." J Appl Physiol 83(5): 1711-20.

Espinosa, F. F. and R. D. Kamm (1997). "Thin layer flows due to surface tension gradients over a membrane undergoing nonuniform, periodic strain." Ann Biomed Eng 25(6): 913-25.

Gong, H., M. Johnson, et al. (1997). "The non-uniform distribution of albumin in human and bovine cornea." Exp Eye Res 65(6): 747-56.

Kamm, R. (1997). "[Mussels as therapy in ancient Crete]." Sudhoffs Arch Z Wissenschaftsgesch 81(2): 235-7.

Sit, A. J., H. Gong, et al. (1997). "The role of soluble proteins in generating aqueous outflow resistance in the bovine and human eye." Exp Eye Res 64(5): 813-21.

Wiggs, B. R., C. A. Hrousis, et al. (1997). "On the mechanism of mucosal folding in normal and asthmatic airways." J Appl Physiol 83(6): 1814-21.

Chesler, N. C. and R. D. Kamm (1998). "Performance analysis of a cardiac assist device in counterpulsation." J Biomech Eng 120(4): 437-45.

Espinosa, F. F. and R. D. Kamm (1998). "Meniscus formation during tracheal instillation of surfactant." J Appl Physiol 85(1): 266-72.

Leon, E. J., N. Verma, et al. (1998). "Mechanical properties of a self-assembling oligopeptide matrix." J Biomater Sci Polym Ed 9(3): 297-312.

Bathe, M. and R. D. Kamm (1999). "A fluid--structure interaction finite element analysis of pulsatile blood flow through a compliant stenotic artery." J Biomech Eng 121(4): 361-9.

Dai, G., J. P. Gertler, et al. (1999). "The effects of external compression on venous blood flow and tissue deformation in the lower leg." J Biomech Eng 121(6): 557-64.

Espinosa, F. F. and R. D. Kamm (1999). "Bolus dispersal through the lungs in surfactant replacement therapy." J Appl Physiol 86(1): 391-410.

Ingenito, E. P., L. Mark, et al. (1999). "Biophysical characterization and modeling of lung surfactant components." J Appl Physiol 86(5): 1702-14.

Kamm, R. D. (1999). "Airway wall mechanics." Annual Review of Biomedical Engineering 1: 47-72.

Caplan, M. R., P. N. Moore, et al. (2000). "Self-assembly of a beta-sheet protein governed by relief of electrostatic repulsion relative to van der Waals attraction." Biomacromolecules 1(4): 627-31.

Caplan, M. R., E. M. Schwartzfarb, et al. (2000). "Controlling the properties of a self-assembling, oligopeptide biomaterial via amino acid sequence." Biophysical Journal 78(1): 14A-14A.

Dai, G., O. Tsukurov, et al. (2000). "An in vitro cell culture system to study the influence of external pneumatic compression on endothelial function [In Process Citation]." J Vasc Surg 32(5): 977-87.

Heldt, T., E. B. Shim, et al. (2000). "Computational model of cardiovascular function during orthostatic stress." Comput Cardiol 27: 777-80.

Huang, H. D., X. P. Zhang, et al. (2000). "Effects of mechanical stress on cellular GFP-actin distribution." Biophysical Journal 78(1): 368A-368A.

Ressler, B., R. T. Lee, et al. (2000). "Molecular responses of rat tracheal epithelial cells to transmembrane pressure." Am J Physiol Lung Cell Mol Physiol 278(6): L1264-72.

Shim, E. B., R. D. Kamm, et al. (2000). "Numerical analysis of blood flow through a stenosed artery using a coupled, multiscale simulation method." Comput Cardiol 27: 219-22.

Huang, H., R. Virmani, et al. (2001). "The impact of calcification on the biomechanical stability of atherosclerotic plaques." Circulation 103(8): 1051-6.

Huang, Y., C. M. Doerschuk, et al. (2001). "Computational modeling of RBC and neutrophil transit through the pulmonary capillaries." J Appl Physiol 90(2): 545-64.

Huang, H., R. D. Kamm, et al. (2001). "Receptor-based differences in human aortic smooth muscle cell membrane stiffness." Hypertension 38(5): 1158-61.

Morris, J., E. P. Ingenito, et al. (2001). "Dynamic behavior of lung surfactant." J Biomech Eng 123(1): 106-13.

Ozawa, E. T., K. E. Bottom, et al. (2001). "Numerical simulation of enhanced external counterpulsation." Ann Biomed Eng 29(4): 284-97.

Swartz, M. A., D. J. Tschumperlin, et al. (2001). "Mechanical stress is communicated between different cell types to elicit matrix remodeling." Proc Natl Acad Sci U S A 98(11): 6180-5. [PDF]

Bathe, M., A. Shirai, et al. (2002). "Neutrophil transit times through pulmonary capillaries: the effects of capillary geometry and fMLP-stimulation." Biophys J 83(4): 1917-33. [PDF]

Caplan, M. R., E. M. Schwartzfarb, et al. (2002). "Control of self-assembling oligopeptide matrix formation through systematic variation of amino acid sequence." Biomaterials 23(1): 219-27. [PDF]

Caplan, M. R., E. M. Schwartzfarb, et al. (2002). "Effects of systematic variation of amino acid sequence on the mechanical properties of a self-assembling, oligopeptide biomaterial." J Biomater Sci Polym Ed 13(3): 225-36.

Dai, G., O. Tsukurov, et al. (2002). "Endothelial nitric oxide production during in vitro simulation of external limb compression." Am J Physiol Heart Circ Physiol 282(6): H2066-75.

Davis, L. J., D. J. Odde, et al. (2002). "The importance of lattice defects in katanin-mediated microtubule severing in vitro." Biophys J 82(6): 2916-27.

Heldt, T., E. B. Shim, et al. (2002). "Computational modeling of cardiovascular response to orthostatic stress." J Appl Physiol 92(3): 1239-54.

Hrousis, C. A., B. J. Wiggs, et al. (2002). "Mucosal folding in biologic vessels." J Biomech Eng 124(4): 334-41.

Huang, H., C. Y. Dong, et al. (2002). "Three-dimensional cellular deformation analysis with a two-photon magnetic manipulator workstation." Biophys J 82(4): 2211-23.

Kamm, R. D. (2002). "Cellular fluid mechanics." Annu Rev Fluid Mech 34: 211-32. [PDF]

McKay, K. O., B. R. Wiggs, et al. (2002). "Zero-stress state of intra- and extraparenchymal airways from human, pig, rabbit, and sheep lung." J Appl Physiol 92(3): 1261-6.

Napadow, V. J., R. D. Kamm, et al. (2002). "A biomechanical model of sagittal tongue bending." J Biomech Eng 124(5): 547-56.

Powers, M. J., K. Domansky, et al. (2002). "A microfabricated array bioreactor for perfused 3D liver culture." Biotechnol Bioeng 78(3): 257-69.

Shim, E. B., C. H. Youn, et al. (2002). Computational modeling of the cardiovascular system after Fontan procedure. Medical Data Analysis, Proceedings. 2526: 105-114.

Shim, E. B. and R. D. Kamm (2002). "Numerical simulation of steady flow in a compliant tube or channel with tapered wall thickness." Journal of Fluids and Structures 16(8): 1009-1027.

Xiao, X., E. T. Ozawa, et al. (2002). "Model-based assessment of cardiovascular health from noninvasive measurements." Ann Biomed Eng 30(5): 612-23.

Hwang W, Marini DM, Kamm RD, Zhang S. Supramolecular structure of helical ribbons self-assembled from a β-sheet peptide. J Chem Phys, 118(1):389-397, 2003.

Jonas, M., H. Huang, et al. (2003). "High temporal resolution fluorescence microrheology." Biophysical Journal 84(2): 134A-134A.

Kaazempur-Mofrad, M. R., M. Bathe, et al. (2003). "Role of simulation in understanding biological systems." Computers & Structures 81(8-11): 715-726.

Younis, H. F., M. R. Kaazempur-Mofrad, et al. (2003). "Computational analysis of the effects of exercise on hemodynamics in the carotid bifurcation." Ann Biomed Eng 31(8): 995-1006.

Williamson, S. D., Y. Lam, et al. (2003). "On the sensitivity of wall stresses in diseased arteries to variable material properties." J Biomech Eng 125(1): 147-55.

127. Lammerding J, Huang H, So PT, Kamm RD, Lee RT. Quantitative measurements of active and passinve mechanical properties of adult cardiac myocytes. EMBS Student Paper Finalist. IEEE Eng Med & Biol, 22(5):124-127, 2003.

128. Karcher H, Lammerding J, Huang H, Lee RT, Kamm RD, and Kaazempur-Mofrad R, A three-dimensional viscoelastic model for cell deformation with experimental verification. Biophys J, 85(5): 3336-49, 2003. [PDF]

129. Kaazempur-Mofrad MR, Younis HF, Patel S, Isasi AG, Chung C, Chan RC, Hinton DP, Lee RT, Kamm RD. Cyclic Strain in Human Carotid Bifurcation and its Potential Correlation to Atherogenesis: Idealized and Anatomically-Realistic Models, J Eng Math: Mathematical Modeling of the Cardiovascular System (Eds: F.N. van de Voss and C.A. Taylor), in press, 2004.

130. Lammerding J, Schultze PC, Takahashi T, Kozlov S, Sullivan T, Kamm RD, Stewart CL, Lee RT. Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction. J Clin Invest, 113(3):370-804, 2004 [PDF]

131. Kaazempur-Mofrad MR, Isasi AG, Younis HF, Chan RC, Hinton DP, Sukhova G, LaMuraglia GM, Lee RT, and Kamm RD. Characterization of the atherosclerotic carotid bifurcation using MRI, finite element modeling, and histology. Ann Biomed Eng 32: 932-946, 2004. [PDF]

132. Lammerding J, Kamm RD, and Lee RT. Mechanotransduction in cardiac myocytes. Ann N Y Acad Sci 1015: 53-70, 2004.

133. Tschumperlin DJ, Dai G, Maly I, Kikuchi T, Laiho LH, McVittie AK, Haley KJ, Lilly CM, So PT, Lauffenburger DA, Kamm RD, Drazen JM. Mechanotransduction via growth factor shedding into the extracellular space. Nature, 429: 83-86, 2004. [PDF]

134. Huang, H, Kamm RD, Lee RT. Cell mechanics and mechanotransduction: pathways, probes, and physiology. Am J Physiol, 287: C1-C11, 2004. [PDF]

135. Mack PJ, Kaazempur-Mofrad MR, Karcher H, Lee RT, and Kamm RD. Force-induced focal adhesion translocation: effects of force amplitude and frequency. Am J Physiol Cell Physiol 287: C954-962, 2004. [PDF]

136. Narmoneva DA, Vukmirovic R, Davis ME, Kamm RD, Lee RT. Endothelial cells promote cardiac myocyte survival and spatial reorganization: Implications for cardiac regeneration. Circulation, 110:962-968, 2004. [PDF]

137. Younis HF, Kaazempur-Mofrad MR, Chan RC, Isasi AG, Hinton DP, Chau AH, Kim LA, and Kamm RD. Hemodynamics and wall mechanics in human carotid bifurcation and its consequences for atherogenesis: investigation of inter-individual variation. Biomech Model Mechanobiol, 2004. [PDF]

138. Hwang W, Zhang S, Kamm RD, and Karplus M. Kinetic control of dimer structure formation in amyloid fibrillogenesis. Proc Natl Acad Sci U S A 101: 12916-12921, 2004. [PDF]

139. Kaazempur Mofrad MR, Golji J, Abdul Rahim NA, and Kamm RD. Force-induced Unfolding of the Focal Adhesion Targeting Domain and the Influence of Paxillin Binding. Mechanics and Chemistry in Biosystems, in press. [PDF]

140. Dai G, Kaazempur-Mofrad MR, Natarajan S, Zhang Y, Vaughn S, Blackman BR, Kamm RD, García-Cardeña G, and Gimbrone MA. Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature. PNAS 101: 14871-14876; 2005. [PDF]

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