Research Focus

Research in the Schauer laboratory takes a systems approach to understanding bacterial pathogenesis. Infectious bacteria interact with host cells by presenting pathogen-associated molecular patterns, by elaborating secreted toxins, and by delivering effector molecules via dedicated secretion systems. The outcome of infection is determined by host responses to these microbial signals. By studying naturally occurring pathogens of mice, cross-talk between the bacterium and host can be investigated at the level of the cell, tissue, organ, and organism. A particular focus is understanding how bacterial infection in the gastrointestinal tract leads to conditions such as inflammatory bowel disease, hepatitis, and cancer.

Recent Publications

Marini RP, Taylor NS, Liang AY, Knox KA, Pena JA, Schauer DB, Fox JG. Characterization of Hemolytic Escherichia coli Strains in Ferrets: Recognition of Candidate Virulence Factor CNF1. J. Clin. Microbiol. 42:5904-5908, 2004.

Sarma-Rupavtarm RB, Ge Z, Schauer DB, Fox JG, Polz MF. Spatial distribution and stability of the eight microbial species of the altered schaedler flora in the mouse gastrointestinal tract. Appl. Environ. Microbiol. 70:2791-2800, 2004.

Young VB, Knox KA, Pratt JS, Cortez JS, Mansfield LS, Rogers AB, Fox JG, Schauer DB. In vitro and in vivo characterization of Helicobacter hepaticus cytolethal distending toxin mutants. Infect. Immun. 72:2521-2527, 2004.

Jellison KL, Distel DL, Hemond HF, Schauer DB. Phylogenetic analysis of the hypervariable region of the 18S rRNA gene of Cryptosporidium oocysts in feces of Canada geese (Branta canadensis): evidence for five novel genotypes. Appl. Environ. Microbiol. 70:452-458, 2004.

Suerbaum S, Josenhans C, Sterzenbach T, Drescher B, Brandt P, Bell M, Droge M, Fartmann B, Fischer HP, Ge Z, Horster A, Holland R, Klein K, Konig J, Macko L, Mendz GL, Nyakatura G, Schauer DB, Shen Z, Weber J, Frosch M, Fox JG. The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus. Proc. Natl. Acad. Sci. USA 100:7901-7906, 2003.

Garcia A, Marini RP, Feng Y, Vitsky A, Knox KA, Taylor NS, Schauer DB, Fox JG. A naturally occurring rabbit model of enterohemorrhagic Escherichia coli-induced disease. J. Infect. Dis. 186:1682-1686, 2002.

Jellison KL, Hemond HF, Schauer DB. Sources and species of cryptosporidium oocysts in the Wachusett Reservoir watershed. Appl. Environ. Microbiol. 68:569-575, 2002.

Solnick, J. V., and D. B. Schauer. 2001. Emergence of diverse Helicobacter species in the pathogenesis of gastric and enterohepatic diseases. Clin. Microbiol. Rev. 14:59-97.

Luperchio, S. A., and D. B. Schauer. 2001. Molecular pathogenesis of Citrobacter rodentium. Microbes Infect. 3:330-340.

Mansfield, K. G., K.-C. Lin, J. V. Newman, D. B. Schauer, J. MacKey, A. A. Lackner, and A. Carville. 2001. Identification of enteropathogenic Escherichia coli in simian immunodeficiency virus-infected infant and adult rhesus macaques. J. Clin. Microbiol. 39:971-976.

Newman, J. V., T. Kosaka, B. J. Sheppard, J. G. Fox, and D. B. Schauer. 2001. Bacterial infection promotes colon tumorigenesis in ApcMin/+ mice. J. Infect. Dis. 184:227-230.

Mansfield, K. G., K.-C. Lin, D. Xia, J. V. Newman, D. B. Schauer, J, MacKey, A. A. Lackner, and A. Carville. 2001. Enteropathogenic Escherichia coli and ulcerative colitis in cotton-top tamarins (Sanguinus oedipus). J. Infect. Dis. 184:803-807.

Schauer, D. B. 2001. Enterohepatic Helicobacter species. in Helicobacter pylori: Physiology and Genetics, Mobley, Mendz, and Hazell, eds. American Scociety for Microbiology Press.

Ge, Z., Y. Feng, D. A. White, D. B. Schauer, and J. G. Fox. 2001. Genomic characterization of Helicobacter hepaticus: ordered cosmid library and comparative sequence analysis. FEMS Microbiol. Lett. 204:147-153.

Fox, J. G., D. D. Schauer, and T. Wadström. 2001. Enterohepatic Helicobacter spp. Curr. Opin. Gastroenterol. 17(Suppl. 1):S28-S31.

Jellison, K. L., H. F. Hemond, and D. B. Schauer. 2002. Sources and species of Cryptosporidium oocysts in the Wachusett reservoir watershed. Appl. Environ. Microbiol. 68:569-575.

García, A., R. P. Marini, Y. Feng, A. Vitsky, K. A. Knox, N. S. Taylor, D. B. Schauer, and J. G. Fox. 2002. A naturally occurring rabbit model of enterohemorrhagic Escherichia coli-induced disease. J. Infect. Dis. 186:1682-1686.

Suerbaum, S., C. Josenhans, T. Sterzenbach, B. Drescher, P. Brandt, M. Bell, M. Droege, B. Fartmann, H.-P. Fischer, Z. Ge, A. Hörster, R. Holland, K. Klein, J. König, L. Macko, G. L. Mendz, G. Nyakatura, D. B. Schauer, Z. Shen, J. Weber, M. Frosch, and J. G. Fox. 2003. The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus. Proc. Natl. Acad. Sci. USA 100:7901-7906.

Jellison, K. L., D. D. Distel, H. F. Hemond, and D. B. Schauer. Phylogenetic analysis of Cryptosporidium species oocysts from Canada geese (Branta canadensis): evidence for five novel genotypes. Submitted for publication.

Marini, R. P. N. S. Taylor, A. Y. Liang, K. A. Knox, D. B. Schauer, and J. G. Fox. Hemolytic Escherichia coli strains producing cytotoxic necrotizing factor 1 are associated with extraintestinal diseases in ferrets. Submitted for publication.

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