Selected Publications

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Khrapko, K, Thilly, WG, van Orsouw, NJ, Zhang, X, Coller, HA, Perls, TT, Upton, M, Vijg, J, and Wei, JY (1999) Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions. Nucleic Acids Research, 27:2434-2441.

Muniappan, BP, and Thilly, WG (1999) Application of constant denaturant capillary electrophoresis (CDCE) to mutation detection in humans. Genetic Analysis Biomolecular Engineering, 14:221-227.

Li-Sucholeiki, X-C, Khrapko, K, Andre, PC, Marcelino, LA, Karger, BL, and Thilly, WG (1999) Applications of CDCE/hifi PCR to human genetic analysis. Electrophoresis, 20:1224-1232.

Marcelino, LA, and Thilly, WG (1999) Mitochondrial mutagenesis in human cells and tissues. Mutation Research, 434:177-203.

Li-Sucholeiki, X-C, and Thilly, WG (2000) A sensitive scanning technology for low frequency nuclear point mutations in human genomic DNA. Nucleic Acids Research, 28:e44.

Ekstrom, PO, Borresen-Dale, AL, Qvist, H, Giercksky, KE, and Thilly, WG (1999) Detection of low-frequency mutations in exon 8 of the TP53 gene by constant denaturant capillary electrophoresis (CDCE). BioTechniques, 27:128-135.

Kim, AS, Li-Sucholeiki, X-C, and Thilly, WG (2001) Applications of constant denaturant capillary electrophoresis and complementary procedures: Measurement of point mutational spectra. Methods in Molecular Biology, 163:175-189.

Tomita-Mitchell, A, Kat, AG, Marcelino, LA, and Li-Sucholeiki, X-C, Goodluck-Griffith, J, and Thilly, WG (2000) Mismatch repair deficient human cells: spontaneous and MNNG-induced mutational spectra in the HPRT gene. Mutation Research, 450:125-138.

Khrapko, K, Coller, HA, Li-Sucholeiki, X-C, Andre, PC, and Thilly, WG (2001) High resolution analysis of point mutations by constant denaturant capillary electrophoresis (CDCE). Methods in Molecular Biology, 163:57-72.

Lim, EL, Tomita, AV, Thilly, WG and Polz, MF (2001) Combination of competitive quantitative PCR and constant-denaturant capillary electrophoresis for high-resolution detection and enumeration of microbial cells. Applied and Environmental Microbiology, 3897-3903.

Muniappan, BP, and Thilly, WG (2002) The DNA polymerase beta replication error spectrum in the adenomatous polyposis coli gene contains human colon tumor mutational hotspots. Cancer Res., 3271-3275.

Kim, AS, Holmquist, GP, and Thilly, WG (2002) High-efficiency DNA ligation for clamp attachment without polymerase chain reaction. Anal Biochem., 179-185.

Xue, MZ, Bonny, O, Morgenthaler, S, Bochud, M, Mooser, V, Thilly, WG, Schild, L, and Leong-Morgenthaler, PM (2002) Use of constant denaturant capillary electrophoresis of pooled blood samples to identify single-nucleotide polymorphisms in the genes (Scnn1a and Scnn1b) encoding the alpha and beta subunits of the epithelial sodium channel. Clin Chem., 718-728.

Tomita-Mitchell, A, Ling, L, Glover, CL, Goodluck-Griffith, J, and Thilly, WG (2003) The mutational spectrum of the HPRT gene from human TK6-cells in vivo share a significant concordant set of hotspots with MNNG treated human cells. Cancer Research, in press.

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