Supplemental Table 1. A subset of genes regulated by 20% glucose. The data shown were used to generate Fig. 6A. Fold change is shown for cells grown in YPD+20% glucose for 30/60/120/240 minutes. The complete set of microarray data can be downloaded from our web site (see Methods).
A. A subset of genes up-regulated by 20% glucose.
ID |
Name |
Gene Function |
Fold
Change |
YFL014W |
HSP12 |
Heat shock protein of 12kDa, induced by heat, osmostress,
oxidative stress and stationary phase |
31/25.2/6.4/8.1 |
YDL222C |
|
Protein with similarity to Sur7p |
16.2/2.3/1.5/1.8 |
YHR087W |
|
Protein of unknown function |
15.9/5.5/4.7/3.9 |
YHR033W |
|
Protein with similarity to Pro1p |
15.2/2.9/1.3/1.3 |
YGR088W |
CTT1 |
Catalase T (cytosolic) |
15.2/2.5/1.1/1.4 |
YOL084W |
|
Protein of unknown function; member of the major facilitator
superfamily (MFS) |
14.6/2.6/1.3/1.2 |
YDL223C |
|
Protein of unknown function |
12.9/2.5/0.9/1 |
YOL150C |
|
Protein of unknown function |
12.9/3.1/3.3/3.4 |
YGR144W |
THI4 |
Thiamine-repressed protein essential for growth in the absence
of thiamine |
12.5/3.4/2.6/2.8 |
YDL023C |
|
Protein of unknown function |
11.9/3.1/3.2/2.9 |
YPL223C |
GRE1 |
Protein induced by osmotic stress |
11.9/2.4/1.1/1.2 |
YGR049W |
SCM4 |
Protein that suppresses temperature-sensitive allele of CDC4
when overexpressed |
10/2.3/2.6/2.7 |
YMR169C |
ALD3 |
Probable aldehyde dehydrogenase (NAD(P)+), likely cytosolic |
9.3/2.6/1.3/1.5 |
YOL151W |
GRE2 |
Protein involved in diamide tolerance and induced by osmotic
stress |
9.3/3.3/2.7/2.4 |
YMR170C |
ALD2 |
Aldehyde dehydrogenase (NAD(P)+), likely cytosolic |
8.3/2/1.3/1.6 |
YDL022W |
GPD1 |
Glycerol-3-phosphate dehydrogenase (NAD+) (cytoplasmic);
involved in glycerol production converting glycerol-3-phosphate and NAD+ to
dihydroxyacetone phosphate and NADH |
8/2.1/2/1.7 |
YML131W |
|
Protein of unknown function |
7.8/3.2/2.2/1.2 |
YJL088W |
ARG3 |
Ornithine carbamyltransferase, catalyzes the sixth step in the
arginine biosynthesis pathway |
7.7/1.8/1.8/1.8 |
YJL108C |
|
Protein of unknown function; member of the major facilitator
superfamily (MFS) |
7/5.4/1.9/1.8 |
YJL116C |
NCA3 |
Protein involved in regulation of synthesis of Atp6p and Atp8p |
6.8/4.7/3.6/2.9 |
YMR173W |
DDR48 |
Stress protein induced by heat shock, DNA damage, or osmotic
stress |
5.9/3.7/1.3/1.4 |
YJL107C |
|
Protein of unknown function |
5.8/3.4/1.9/1.8 |
YHR103W |
SBE22 |
Protein required for bud growth |
5.6/1.8/1.6/1.7 |
YOR177C |
|
Protein of unknown function, putative coiled-coil protein
induced early in sporulation |
5.5/3.3/1.1/1.2 |
YMR090W |
|
Protein with similarity to malate dehydrogenases |
5.3/3.5/1.8/2.1 |
YMR250W |
|
Protein with similarity to glutamate decarboxylase |
5.1/1.7/1/1.1 |
YGR043C |
|
Protein with strong similarity to Tal1p |
4.8/3.2/1.7/1.5 |
YOR161C |
|
Protein of unknown function, member of the major facilitator
superfamily (MFS) |
4.8/3.9/1.7/1.6 |
YHR095W |
|
Protein of unknown function |
4.7/2.5/2/1.6 |
YHR039C |
|
Protein with strong similarity to aldehyde dehydrogenases |
4.6/2.1/1.6/2.1 |
YER062C |
HOR2 |
DL-glycerol phosphate phosphatase |
4.5/2.3/1.9/1.7 |
YML070W |
DAK1 |
Putative dihydroxyacetone kinase |
4/2.4/1.5/1.5 |
YHR139C |
SPS100 |
Sporulation specific protein involved in spore wall formation;
first appears at 12h of sporulation |
3.6/1.7/1.5/1.3 |
YLR108C |
|
Protein of unknown function |
3.5/2.7/2.9/2.6 |
YGR059W |
SPR3 |
Sporulation-specific septin |
3.4/2/1.2/1.2 |
YMR173W-A |
|
Stress protein induced by heat shock, DNA damage, or osmotic
stress |
3.4/2.5/1.4/1.2 |
YOL053C-A |
SPE2 |
Stress protein induced by DNA damage, heat shock, osmotic shock
and oxidative stress |
3.3/2.5/1.4/1.4 |
YBR222C |
FAT2 |
Peroxisomal AMP-binding protein |
3.2/1.6/1.3/1.2 |
YNR076W |
PAU6 |
Protein with strong similarity to members of the PAU1 family |
3/1.6/1.5/4.1 |
YLR338W |
|
Protein of unknown function |
2.9/1.5/1.2/1.6 |
YER119C-A |
|
Protein of unknown function |
2.9/1.6/0.9/0.9 |
YIL108W |
|
Protein of unknown function |
2.8/1.5/1.3/1.3 |
YFR022W |
|
Protein with similarity to Rod1p |
2.8/2.2/1.2/1.2 |
YJR078W |
|
Protein with similarity to indoleamine 2,3-dioxygenase |
2.5/1.6/1.1/1 |
YDR368W |
YPR1 |
Protein with similarity to members of the aldo/keto reductase
family |
2.4/1.6/1.5/1.4 |
YGL141W |
|
Putative ubiquitin-protein ligase |
2.3/1.7/1.1/1.9 |
YJL093C |
TOK1 |
Two-domain outwardly-rectifying voltage-gated potassium channel |
2.3/1.6/1.2/1.1 |
YLR046C |
|
Protein with similarity to Rtm1p |
2.2/1.6/1.6/1.6 |
YLR030W |
|
Protein of unknown function |
2.2/1.6/1.3/1.2 |
YJR162C |
|
Protein with similarity to subtelomerically-encoded proteins
including Gin11p and Ykl225p |
2.1/1.6/1.5/1.1 |
B. A subset of genes down-regulated by 20% glucose.
ID |
Name |
Gene Function |
Fold
Change |
YJL218W |
|
Protein
with similarity to E. coli galactoside O-acetyltransferase |
-5.5/-2.1/-1.2/-1.8 |
YJL217W |
|
Protein
of unknown function |
-5.4/-2.2/-1/-1.4 |
YBL028C |
|
Protein
of unknown function |
-3.4/-1.8/-1.2/-1.2 |
YLR214W |
FRE1 |
Ferric
and cupric reductase; acts on ferric iron chelates external to the cell |
-3.3/-1.6/-1/-1 |
YOR342C |
|
Protein
of unknown function |
-3.2/-1.7/-1.2/-1.3 |
YFR001W |
|
Protein
of unknown function |
-2.9/-1.8/-1.2/-1.3 |
YNL078W |
|
Protein
of unknown function |
-2.8/-1.6/1/-1.4 |
YDR357C |
|
Protein
of unknown function |
-2.6/-1.9/-1/-1.2 |
YAL033W |
POP5 |
Subunit
of both RNase P and RNase MRP |
-2.6/-1.6/-1.3/-1.2 |
YPR124W |
CTR1 |
Copper
transport protein; required for high-affinity uptake of copper |
-2.6/-2.1/-1.5/-1.3 |
YIL127C |
|
Protein
of unknown function |
-2.5/-1.6/-1.3/-1.2 |
YFR015C |
GSY1 |
UDP-glucose-starch
glucosyltransferase (glycogen synthetase) isoform 1 |
-2.5/-1.8/-3.1/-3.2 |
YGR177C |
ATF2 |
Sterol
O-acetyltransferase; acetylates certain toxic steroids such as pregnenolone
to render them excretable |
-2.5/-1.8/-1.4/-1.3 |
YGR035C |
|
Protein
of unknown function |
-2.5/-1.8/-1.6/-1.9 |
YBR154C |
RPB5 |
Shared
subunit of RNA polymerases I, II, and III (ABC27) |
-2.4/-1.6/-1/-1.1 |
YJR067C |
YAE1 |
Essential
protein of unknown function |
-2.4/-1.5/-1.5/-1.3 |
YBR083W |
TEC1 |
Transcriptional
activator; involved with STE12 in pseudohyphal formation |
-2.4/-1.7/-1.3/-1.3 |
YHR055C |
CUP1-2 |
Metallothionein
(copper chelatin); identical to Cup1Ap |
-2.3/-1.9/-1.4/-2.4 |
YNL174W |
|
Protein
of unknown function |
-2.3/-1.7/-1.3/-1.2 |
YOR294W |
RRS1 |
Regulator
of ribosome synthesis |
-2.3/-1.7/-1.3/-1.1 |
YGL029W |
CGR1 |
Predicted
coiled-coil protein, down-regulated after diauxic shift |
-2.3/-1.5/-1.4/-1.3 |
YPR082C |
DIB1 |
Protein
required for mitotic spindle formation or function |
-2.3/-1.8/-1.2/-1.2 |
YLR460C |
|
Protein
with strong similarity to Ycr102p |
-2.3/-1.8/-1.7/-1.7 |
YDR152W |
|
Protein
of unknown function |
-2.3/-1.8/-1.4/-1.4 |
YOR004W |
|
Protein
of unknown function |
-2.3/-1.6/-1.1/-1.1 |
YMR136W |
GAT2 |
Protein
of unknown function |
-2.3/-1.7/-2.2/-2.2 |
YDL037C |
|
Protein
with similarity to glucan 1,4-alpha-glucosidase |
-2.2/-1.8/-1.5/-1.5 |
YMR193C-A |
|
Protein
of unknown function |
-2.2/-1.7/1.1/-1.1 |
YDR469W |
|
Protein
with similarity to C. elegans dpy-30 gene product, GB |
-2.2/-1.8/-1.4/-1.3 |
YGR076C |
MRPL25 |
Mitochondrial
ribosomal protein of the large subunit YMR26 (YmL25) |
-2.2/-1.7/-1.6/-1.5 |
YBR024W |
SCO2 |
Protein
possibly involved in stability of Cox1p and Cox2p; homolog of Sco1p |
-2.2/-1.7/-1.1/-1.5 |
YGR272C |
|
Protein
of unknown function |
-2.2/-1.6/-1.1/1 |
YNL110C |
|
Protein
of unknown function |
-2.2/-1.5/-1.1/-1.3 |
YKL109W |
HAP4 |
Transcription
factor with acidic activation domain, component of Hap2p-Hap3p-Hap4p-Hap5p
complex involved in activation of CCAAT box-containing genes |
-2.1/-1.7/-2.7/-3 |
YLR066W |
SPC3 |
Subunit
of signal peptidase complex |
-2.1/-1.5/-1.5/-1.4 |
YLL062C |
|
Protein
of unknown function |
-2/-1.6/-2.2/-2.4 |
YKL186C |
MTR2 |
Protein
involved in mRNA transport, has similarity to E. coli mbeA |
-2/-1.6/-1.1/-1.4 |
YBR298C |
MAL31 |
High
affinity maltose/H+ symporter (maltose permease) member of the sugar permease
family |
-2/-1.6/-1.8/-2.2 |
YPR143W |
|
Protein
of unknown function |
-2/-1.7/-1.4/-1.2 |
YDR041W |
|
Mitochondrial
ribosomal protein |
-2/-1.5/-1.3/-1.2 |
YNL114C |
|
Protein
of unknown function, questionable ORF |
-1.9/-1.5/-1.1/-1.2 |
YGR030C |
POP6 |
Subunit
of both RNase P and RNase MRP |
-1.9/-1.6/-1/-1.1 |
YJR133W |
XPT1 |
Xanthine
phosphoribosyl transferase |
-1.9/-1.5/-1.3/-1.1 |
YJR101W |
|
Protein
with similarity to superoxide dismutase |
-1.9/-1.5/-1.1/-1.3 |
YPL158C |
|
Protein
of unknown function |
-1.9/-1.5/1.3/1 |
YHR081W |
|
Protein
of unknown function |
-1.9/-1.6/-1.5/-1.4 |
YKR083C |
|
Protein
with similarity to paramyosin |
-1.9/-1.5/-1.3/-1.3 |
YBR201W |
DER1 |
Protein
involved in degradation of misfolded soluble proteins in the endoplasmic
reticulum |
-1.9/-1.5/-1.3/-1.3 |
YDR073W |
SNF11 |
Component
of SWI-SNF global transcription activator complex; acts to assist
gene-specific activators through chromatin remodeling |
-1.8/-1.5/-1.7/-1.7 |
YBL043W |
ECM13 |
Protein
possibly involved in cell wall structure or biosynthesis |
-1.8/-1.5/1.1/-1.2 |