Sinskey Lab Publications

2012
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pre-1990

Riedel, S.L., J. Bader, C.J. Brigham, C.F. Budde, Z.A.M. Yusof, C. Rha, A.J. Sinskey. 2012. Production of Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) by Ralstonia eutropha in High Cell Density Palm Oil Fermentations. Biotechnol. Bioeng. 109(1):74-83.
Budde, C.F., S.L. Riedel, F. Hübner, S. Risch, M.K. Popović, C. Rha, and A.J. Sinskey.  2011Growth and polyhydroxybutyrate production by Ralstonia eutropha in emulsified plant oil medium.  Appl. Microbiol. Biotechnol. 89(5):1611-1619.
E.D. Nikolaeva, E.I. Shiskatskaya, K.E. Mochalov, T.G. Volova, and A.J. Sinskey. 2011. Comparative investigation of polyhydroxyalkanoate scaffolds with various chemical compositions. Cell Transplantation and Tissue Engineering (Russian journal). 4(4): pages TBD.
Volova, T.G., N.O. Zhila, G.S. Kalacheva, V.A. Sokolenko, and A.J. Sinskey. 2011. Synthesis of 3-Hydroxybutyrate-co-4-Hydroxybutyrate copolymers by Hydrogen-oxidizing Bacteria. Appl. Biochem. Microbiol. 48(1):108.
Brigham, C.J., K. Kurosawa, C. Rha, and A.J. Sinskey. 2011. Bacterial Carbon Storage to Value Added Products. J. Microbial Biochem. Technol. S3:002.
Sambanthamurthi, R., Y.A. Tan, K. Sundram, K.C. Hayes, M. Abeywardena, S.S. Leow, S.D. Sekaran, T.G. Sambandan, C. Rha, A.J. Sinskey, K. Subramaniam, S. Fairus, M.B. Wahid. 2011. Positive outcomes of oil palm phenolics on degenerative diseases in animal models. Br. J. Nutr. 106(11):1664-75.
Sambanthamurthi, R., Y.A. Tan, K. Sundram, M. Abeywardena, T.G. Sambandan, C. Rha, A.J. Sinskey, K. Subramaniam, S.S. Leow, K.C. Hayes, M.B. Wahid. 2011. Oil palm vegetation liquor: a new source of phenolic bioactives. Br. J. Nutr. 106(11):1655-1663.
Song, Y., K. Matsumoto, M. Yamada, A. Gohda, C.J. Brigham, A.J. Sinskey and S. Taguchi. 2011. Engineered Corynebacterium glutamicum as an endotoxin-free platform strain for lactate-based polyester production. Appl. Microbiol. Biotechnol. Epub.
Bhubalan, K., J.A. Chuah, F. Shozui, C.J. Brigham, S. Taguchi, A.J. Sinskey, C. Rha, and K. Sudesh. 2011. Characterization of the highly active polyhydroxyalkanoate synthase of Chromobacterium sp. strain USM2. Appl. Environ. Microbiol. 77(9):2926-33.
Holder, J.W., J.C. Ulrich, A.C. DeBono, P.A. Godfrey, C.A. Desjardins, J. Zucker, Q. Zeng, A.L.B. Leach, I. Ghiviriga, C. Dancel, T. Abeel, D. Gevers, C.D. Kodira, B. Desany, J.P. Affourtit, B.W. Birren, and A.J. Sinskey. 2011. Comparative and Functional Genomics of Rhodococcus opacus PD630 for Biofuels Development. PLoS Genet. 7(9). E-pub.
Yang, Y.H., C. Brigham, L. Willis, C. Rha, and A. Sinskey.  2011Improved detergent-based recovery of polyhydroxyalkanoates (PHAs).  Biotechnol. Lett. 33(5):937-942.
Budde, C.F., S. L. Riedel, L.B. Willis, C. Rha, and A.J. Sinskey.  2011Production of Poly(3-hydroxybutyrate-co-3-hydroxy-hexanoate) from Plant Oil with Engineered Ralstonia eutropha Strains. Appl. Environ. Microbiol. In press.
Lee, K.S., P. Boccazzi, A.J. Sinskey, and R.J. Ram.  2011Microfluidic chemostat and turbidostat with flow rate, oxygen, and temperature control for dynamic continuous culture.  Lab on a Chip. E-pub.
Kurosawa, K., P. Boccazzi, N. de Almeida, and A.J. Sinskey.  2010High-cell-density batch fermentation of Rhodococcus opacus PD630 using a high glucose concentration for triacylglycerol production.  J. Biotechnol. 147:212-218.
Yang, Y.H., C.J. Brigham, C.F. Budde, P. Boccazzi, L.B. Willis, M.A. Hassan, Z.A. Yusof, C. Rha, and A.J. Sinskey.  2010Optimization of growth media components for polyhydroxyalkanoate (PHA) production from organic acids by Ralstonia eutropha.  Appl. Microbiol. Biotechnol.  87(6):2037-2045.
Puglisi, E., M.J. Cahill, P.A. Lessard, E. Capri, A.J. Sinskey, J.A.C. Archer, and P. Boccazzi.  2010Transcriptional Response of Rhodococcus aetherivorans I24 to Polychlorinated Biphenyl-Contaminated Sediments.  Microb. Ecol. 60:505-515.
Budde, C.F., A.E. Mahan, J. Lu, C. Rha, and A.J. Sinskey.  2010Roles of Multiple Acetoacetyl-CoA Reductases in Polyhydroxybutyrate Biosynthesis in Ralstonia eutropha H16.  J. Bacteriol. 192(20):5319-28.
Brigham, C.J., C.F. Budde, J.W. Holder, Q. Zeng, A.E. Mahan, C. Rha, and A.J. Sinskey.  2010Elucidation of β-oxidation Pathways in Ralstonia eutropha H16 by Examination of Global Gene Expression.  J. Bacteriol. 192(20):5454-64.
Kurosawa, K., D.P. MacEachran, and A.J. Sinskey.  2010Antibiotic Biosynthesis Following Horizontal Gene Transfer: New Milestone for Novel Natural Product Discovery?  Expert Opinion on Drug Discovery 5(9):819-825.
MacEachran, D.P., M.E. Prophete and A.J. Sinskey.  2010The Rhodococcus opacus PD630 heparin-binding hemagglutinin homolog TadA mediates lipid body formation.  Appl. Environ. Microbiol. 76(21):7217-7225.
Parveez, G.K.A., B. Bohari, N.H. Ayub, A.M.M. Yunus, O.A. Rasid, A.T. Hashim, Z. Ishak, M.A.A. Manaf, A.K. Din, G. York, Y.B. Jo, and A.J. Sinskey. 2008. Transformation of PHB and PHBV genes driven by maize ubiquitin promoter into oil palm for the production of biodegradable plastics.  J. Oil Palm Research S2:77-86.
Omar, W.S.W., L.B. Willis, C. Rha, A.J. Sinskey, U.S. Ramli, A.M.M. Yunus, G.K.A. Parveez, and R. Sambanthamurthi. 2008. Isolation and utilization of acetyl-CoA carboxylase from oil palm (Elaeis guineensis) mesocarp. J. Oil Palm Research S2:97-107.
Willis, L.B, W.S.W. Omar, R. Sambanthamurthi, and A.J. Sinskey. 2008. Non-radioactive Assay for Acetyl-CoA Carboxylase Activity. J. Oil Palm Research S2:30-36.
Willis, L.B., G.M. York, P.A. Lessard, Y.B. Jo, O.A. Rasid, M.A.A. Manaf, C. Park and A.J. Sinskey. 2008. Reagents for Generation and Analysis of Bioplastic Producing Plants. J. Oil Palm Research S2:56-68.
Kurosawa, K., I. Ghiviriga, T.G. Sambandan, P.A. Lessard, J.E. Barbara, C.K. Rha, and A.J. Sinskey. 2008. Rhodostreptomycins, Antibiotics Biosynthesized Following Horizontal Gene Transfer from Streptomyces padanus to Rhodococcus fascians. J. Am. Chem. Soc. 130(4):1126-7.
Choi, D.S., M.H.C. Andrade, L.B. Willis, C. Cho, J. Schoenheit, P. Boccazzi, R. Sambanthamurthi, A.J. Sinskey, and C.K. Rha. 2008. Effect of Agitation and Aeration on Yield Optimization of Oil Palm Suspension Culture. J. Oil Palm Research Special Issue 1:23-34.
Willis, L.B., P.A. Lessard, J.A Parker, X.M. O’Brien, and A.J. Sinskey. 2008. Functional annotation of oil palm genes using an automated bioinformatics approach. J. Oil Palm Research 1:35-43.
Willis, L.B., G.A. Gil, H.L.T. Lee, D.S. Choi, J. Schoenheit, R.J. Ram, C. Rha, and A.J. Sinskey. 2008. Application of spectroscopic methods for the automation of oil palm culture. J. Oil Palm Research 1:1-13.
Rafat, M., K.W. Fong, A. Goldsipe, B.C. Stephenson, S.T. Coradetti, T.G. Sambandan, A.J. Sinskey, and C.K. Rha. 2008. Association (micellization) and partitioning of aglycon triterpenoids.  J. Colloid Interface Science.  325:324-330.
Abdullah, M.A., A. Rahmah, A.J. Sinskey, and C.K. Rha. 2008. Cell Engineering and Molecular Pharming for Biopharmaceuticals. Open Med. Chem. J. 2:49-61.
Thiers, F.A., A.J. Sinskey, and E.R. Berndt. 2008. Trends in the globalization of clinical trials. Nat. Rev. Drug Discovery 7:13-14.
Yang, J.C., P.A. Lessard, and A.J. Sinskey. 2007. Characterization of the mobilization determinants of pAN12, a small replicon from Rhodococcus erythropolis AN12. Plasmid. 57(1):71-81.
Yang, J.C., P.A. Lessard, N. Sengupta, S.D. Windsor, X.M. O’Brien, M. Bramucci, J.F. Tomb, V. Nagarajan, and A.J. Sinskey. 2007. TraA is required for megaplasmid conjugation in Rhodococcus erythropolis AN12. Plasmid. 57(1):55-70.
Govindan, G. T.G. Sambandan, M. Govindan, A. Sinskey, J. Vanessendelft, I. Adenan, C.K. Rha. 2007. A Bioactive Polyacetylene Compound Isolated from Centella asiatica. Planta Med. 73(6):597-9.
Stallings, S.C., D. Huse, S.N. Finkelstein, W.H. Crown, W.P. Witt, J. Maguire, A.J. Hiller, A.J. Sinskey and G.S. Ginsburg. 2006. A Framework to Evaluate the Economic Impact of Pharmacogenomics. Pharmacogenomics. 7(6):853-862.
Zanzotto, A, P. Boccazzi, N. Gorret, T.K. Van Dyk, A.J. Sinskey, and K.F. Jensen. 2006. In situ measurement of bioluminescence and fluorescence in an integrated microbioreactor. Biotechnol. Bioeng. 93(1):40-47.
Plaggenborg, R., J. Overhage, A. Loos, J.A.C. Archer, P. Lessard, A.J. Sinskey, A Steinbüchel, and H. Priefert. 2006. Potential of Rhodococcus strains for biotechnological vanillin production from ferulic acid and eugenol. Appl. Microbiol. Biotechnol. 72(4):745-755.
Lee, H.L.T., P. Boccazzi, R.J. Ram, and A.J. Sinskey. 2006. Microbioreactor arrays with integrated mixers and fluid injectors for high-throughput experimentation with pH and dissolved oxygen control. Lab Chip. 6(9):1229-1235.
Zhang, Z., N. Szita, P. Boccazzi, A.J. Sinskey, and K.F. Jensen. 2006. A well-mixed, polymer-based microbioreactor with integrated optical measurements. Biotechnol. Bioeng. 93(2):286-96.
Boccazzi, P., Z. Zhang, K. Kurosawa, N. Szita, S. Bhattacharya, K. Jensen, and A.J. Sinskey. 2006. Differential gene expression profiles and real-time measurements of growth parameters in Saccharomyces cerevisiae grown in micro-liter scale bioreactors equipped with internal stirring. Biotechnol. Prog. 22:710-717.
Cho, C.W., D.S. Choi, M.H. Cardone, C.W. Kim, A.J. Sinskey, and C. Rha. 2006. Glioblastoma cell death induced by Asiatic acid. Cell Biol. Toxicol. 22(6):393-408.
Zhang, Z., P. Boccazzi, H.G. Choi, G. Perozziello, A.J. Sinskey, and K.F. Jensen. 2006. Microchemostat-microbial continuous culture in a polymer-based, instrumented microbioreactor. Lab Chip. 6(7):906-913.
Kurosawa, K., V.P. Bui, J.L. Vanessendelft, L.B. Willis, P.A. Lessard, I. Ghiviriga, T.G. Sambandan, C.K. Rha, and A.J. Sinskey. 2006. Characterization of Streptomyces MITKK-103, a newly isolated actinomycin X(2)-producer. Appl. Microbiol. Biotechnol. 72(1):145-54.
Tian, J., A. J. Sinskey, and J. Stubbe. 2005. Detection of Intermediates from the Polymerization Reaction Catalyzed by a D302A Mutant of Class III Polyhydroxyalkanoate (PHA) Synthase. Biochemistry. 44(5):1495-1503.
Tian, J., A. J. Sinskey and J. Stubbe. 2005. Kinetic Studies of Polyhydroxybutyrate Granule Formation in Wautersia eutropha H16 By Transmission Electron Microscopy. J. Bacteriol. 187(11):3814-3824.
Tian, J., A. He, A.G. Lawrence, P. Liu, N. Watson, A.J. Sinskey, and J. Stubbe. 2005. Analysis of Transient Polyhydroxybutyrate Production in Wautersia eutropha H16 by Quantitative Westerns and Transmission Electron Microscopy. J. Bacteriol. 187(11):3825-3832.
Lawrence, A.G., J. Choi, C. Rha, J. Stubbe, and A.J. Sinskey. 2005. In vitro analysis of the chain termination reaction in the synthesis of poly-(R)-b-hydroxybutyrate by the Class III synthase from Allochromatium vinosum. Biomacromolecules. 6(4):2113-2119.
Abdullah, M.A., N.H. Lajis, A.M. Ali, M. Marziah, A.J. Sinskey, and C. Rha. 2005. Issues in Plant Cell Culture Engineering for Enhancement of Productivity. Developments in Chemical Engineering & Mineral Processing – The Australasian Research Journal. 13(5/6):573-587.
Stallings, S., A.J. Sinskey, and S.N. Finkelstein. 2005. Considerations in the Economic Assessment of the Value of Molecular Profiling. In: Surrogate Tissue Analysis: Genomic, Proteomic, and Metabolomic Approaches. Burczynski, M.E. and Rockett, J.C. (eds.), CRC Press Taylor & Francis Group: Boca Raton, FL. pp. 263-274.
Szita, N., P. Boccazzi, Z. Zhang, P. Boyle, A.J. Sinskey and K.F. Jensen. 2005. Development of a Multiplexed Microbioreactor System for High-Throughput Bioprocessing. Lab Chip. 5(8):819-826.
Boccazzi, P., A. Zanzotto, N. Szita, S. Bhattacharya, K.F. Jensen, and A.J. Sinskey. 2005. Gene expression analysis of Escherichia coli grown in miniaturized bioreactor platforms for high-throughput analysis of growth and genomic data. Appl. Microbiol. Biotechnol. 68:518-532.
Lawrence, A.G., J. Schoenheit, A. He, J. Tian, P. Liu, J. Stubbe, and A.J. Sinskey. 2005. Transcriptional analysis of Ralstonia eutropha genes related to poly-(R)-3-hydroxybutyrate homeostasis during batch fermentation. Appl. Microbiol. Biotechnol. 68(5):663-72.
Tian, J., A.J. Sinskey, and J. Stubbe. 2005. Class III Polyhydroxybutyrate Synthase: Involvement in Chain Termination and Reinitiation. Biochemistry. 44(23):8369-8377.
Stubbe, J., J. Tian, A. He, A.J. Sinskey, A. Lawrence, and P. Liu. 2005. Nontemplate-dependent polymerization processes: Polyhydroxyalkanoate Synthases as a Paradigm. Annu. Rev. Biochem. 74:433-480.
Sinskey, A.J., S.N. Finkelstein, and S.M. Cooper. 2005. A Cure for Multiple Sclerosis in Our Lifetime? Pharmaceutical Discovery. 5(6):40-43.
Sinskey, A.J., S.N. Finkelstein, and S.M. Cooper. 2005. The Consequences of Limiting Stem Cell Research: Health and Economic Considerations. Pharmaceutical Discovery. 5(4):22-24.
Lessard, P.A., X.M. O'Brien, D.H. Currie, and A.J. Sinskey. 2004. pB264, a small, mobilizable, temperature sensitive plasmid from Rhodococcus. BMC Microbiology. 4(1):15-28.
Finkelstein, S.N., A.J. Sinskey, and S.M. Cooper. 2004. Biobanks: Will They Help Promote the Genomics Revolution? Pharmaceutical Discovery. 4(9):20-24.
Sinskey, A.J., S.N. Finkelstein, and S.M. Cooper. 2004. Medical Imaging in Drug Discovery, Part III. PharmaGenomics. 4(5):18-22.
Sinskey, A.J., S.N. Finkelstein, and S.M. Cooper. 2004. Medical Imaging in Drug Discovery, Part II. PharmaGenomics. 4(4):20-24.
Sinskey, A.J., S.N. Finkelstein, and S.M. Cooper. 2004. Medical Imaging in Drug Discovery, Part I. PharmaGenomics. 4(3):20-26.
Priefert, H. X.M. O'Brien, P.A. Lessard, A.F. Dexter, E.E. Choi, S. Tomic, G. Nagpal, J.J. Cho, M. Agosto, L. Yang, S.L. Treadway, L. Tamashiro, M. Wallace, and A.J. Sinskey. 2004. Indene bioconversion by a toluene-inducible dioxygenase of Rhodococcus sp. I24. Appl. Microbiol. Biotechnol. 65(2):168-76.
Ozminkowski, R.J., W.D. Marder, K. Hawkins, S. Wang, S.C. Stallings, S.N. Finkelstein, A.J. Sinskey, and D. Wierz. 2004. The Use of Disease-Modifying New Drugs for Multiple Sclerosis Treatment in Private-Sector Health Plans. Clin. Ther. 26(8):1341-1354.
Zanzotto, A., N. Szita, P. Boccazzi, P. Lessard, A.J. Sinskey, and K.F. Jensen. 2004. Membrane-aerated microbioreactor for high-throughput bioprocessing. Biotechnol. Bioeng. 87(2):243-254.
Lee, H.L.T., P. Boccazzi, N. Gorret, R.J. Ram, and A.J. Sinskey. 2004. In situ bioprocess monitoring of Escherichia coli bioreactions using Raman spectroscopy. Vibrational Spectroscopy. 35:131-137.
Gorret, N., S.K. bin Rosli, S.F. Oppenheim, L.B. Willis, P.A. Lessard, C. Rha, and A.J. Sinskey. 2004. Bioreactor culture of oil palm (Elaeis guineensis) and effects of nitrogen source, inoculum size, and conditioned medium on biomass production. J. Biotechnol. 108:253-263.
Willis L.B., P.A. Lessard, and A.J. Sinskey. 2004. Production of threonine and branched chain amino acids in Corynebacterium glutamicum. In: Handbook of Corynebacterium glutamicum. Eggeling, L. and Bott, M. (eds.), CRC Press, Boca Raton. In Press.
Sinskey, A.J., S.N. Finkelstein, and S.M. Cooper. 2004. The Question of Compliance. PharmaGenomics. 4(1):16-19.
Nielsen, U.B., M.H. Cardone, A.J. Sinskey, G. MacBeath, and P.K. Sorger. 2003. Profiling receptor tyrosine kinase activation using antibody microarrays. PNAS. 100(16):9330-9335.
Glanemann, C., A. Loos, N. Gorret, L.B. Willis, X.M. O'Brien, P.A. Lessard, and A.J. Sinskey. 2003. Disparity between changes in mRNA abundance and enzyme activity in Corynebacterium glutamicum: implications for DNA microarray analysis. Appl. Microbiol. Biotechnol. 61:61-68.
Coldren, C.D., P. Hashim, J.M. Ali, S. Oh, A.J. Sinskey, C. Rha. 2003. Gene expression changes in the human fibroblast induced by Centella asiatica triterpenoids. Planta Med. 69(8):725-32.
Osman, A., B. Jordan, P.A. Lessard, A.J. Sinskey, C. Rha, and D.E. Housman. 2003. Genetic diversity of Eurycoma longifolia inferred from single nucleotide polymorphisms. Plant Physiol. 131(3):1294-1301.
York, G.M., J. Lupberger, J. Tian, A. Lawrence, J. Stubbe, and A.J. Sinskey. 2003. Ralstonia eutropha H16 Encodes Two and Possibly Three Intracellular Poly[D-(-)-3-hydroxybutyrate] (PHB) Depolymerase Genes. J. Bacteriol. 185(13):3788-3794.
Finkelstein, S.N., A.J. Sinskey, and S.M. Cooper. 2003. A Public/Private Partnership for Dual-Use Antibiotics. PharmaGenomics. 3(3):18-22.
An, G.-H. and A.J. Sinskey. 2003. Accumulation of Isoleucine Intermediates in the Isoleucine Producing Recombinant of Corynebacterium lactofermentum ATCC 21799. Food Sci. Biotechnol. 12:137-141.
Finkelstein, S.N., A.J. Sinskey, and S.M. Cooper. 2003. Getting Personal with Pain. PharmaGenomics. 3(6):18-21.
Zhang, Z., N. Szita, P. Boccazzi, A.J. Sinskey, and K.F. Jensen. 2003. Monitoring and control of cell growth in fed-batch microbioreactors. Proceedings of MicroTAS 2003 - 7th International Conference on Miniaturized Chemical and Biochemical Analysis Systems, M.A. Northrup, K.F. Jensen and D.J. Harrison (Eds.), Squaw Valley, CA. Tranducers Research Foundation. pp. 765-768.
Choi, H.-G., Z. Zhang, P. Boccazzi, P.E. Laibinis, A.J. Sinskey, and K.F. Jensen. 2003. Poly(ethylene glycol) (PEG) V modified poly (dimethysiloxane) (PDMS) for protein and cell- resistant surfaces in microbioreactor. Proceedings of MicroTAS 2003 - 7th International Conference on Miniaturized Chemical and Biochemical Analysis Systems, M.A. Northrup, K.F. Jensen and D.J. Harrison (Eds.), Squaw Valley, CA. Tranducers Research Foundation. pp. 1105-1108.
Lee, H.L.T, P. Boccazzi, N. Gorret, R.J. Ram, and A.J. Sinskey. 2003. Raman spectroscopy for in-situ bioprocess monitoring. Proceedings of the Second International Conference on Advanced Vibrational Spectroscopy, Aug. 24-29, Nottingham, UK.
Singh, R., P.A. Lessard, S.G. Tan, J.M. Panandam, A. Sinskey, and S.C. Cheah. 2003. Preliminary attempts at the construction of large insert DNA libraries of oil palm (Elaeis guineensis Jacq.) J. Oil Palm Research. 15(1):12-20.
Sinskey, A.J., S.N. Finkelstein, and S.M. Cooper. 2003. See you in December? PharmaGenomics. 3(8):24-25.
O'Brien, X.M., J.A. Parker, P.A. Lessard, and A.J. Sinskey. 2002. Engineering an indene bioconversion process for the production of cis-aminoindanol: a model system for the production of chiral synthons. Appl. Microbiol. Biotechnol.59:389-399.
Szita, N., A. Zanzotto, P. Boccazzi, A.J. Sinskey, M.A. Schmidt, and K.F. Jensen. 2002. Monitoring of cell growth, oxygen and pH in microfermentors. In: Micro Total Analysis Systems 2002. Y. Baba, S. Shoji, and A. van den Berg, (eds), Dordrecht: Kluwer Academic. pp. 7-9.
Sinskey, A.J., S.N. Finkelstein, and S.M. Cooper. 2002. Getting to "Rational" Drug Design - at Last. PharmaGenomics. 2(6):18-22.
Finkelstein, S.N., A.J. Sinskey, and S.M. Cooper. 2002. The Coming Paradigm Shift in Pharmaceuticals. PharmaGenomics 2(5):26-28.
Sinskey, A.J., S.N. Finkelstein, and S.M. Cooper. 2002. The Promise of Protein Microarrays. PharmaGenomics 2(4):20-24.
Sinskey, A.J., S.N. Finkelstein, and S.M. Cooper. 2002. Integrating the Science and Technology Revolutions. PharmaGenomics 2(3):18-21.
Stafford, D.E., K.S. Yanagimachi, P.A. Lessard, S.K. Rijhwani, A.J. Sinskey, and G. Stephanopoulos. 2002. Optimizing bioconversion pathways through systems analysis and metabolic engineering. Proc. Natl. Acad. Sci. 99(4):1801-1806.
Lessard, P.A., H. Kulaveerasingam, G.M. York, A. Strong, and A.J. Sinskey. 2002. Manipulating Gene Expression for the Metabolic Engineering of Plants. Metab. Eng. 4:67-79.
Stallings, S.C., R.H. Rubin, T.J. Allen, C.L. Cooney, S.N. Finkelstein, and A.J. Sinskey. 2002. Technological Innovation in Pharmaceuticals. PharmaVentures: Pharmaceutical Discovery and Development 2nd ed. pp. 12-16.
York, G.M., J. Stubbe, and A.J. Sinskey. 2002. The Ralstonia eutropha PhaR Protein Couples Synthesis of the PhaP Phasin to the Presence of Polyhydroxybutyrate in Cells and Promotes Polyhydroxybutyrate Production. J. Bacteriol. 184(1):59-66.
Sang, J.S., K.D. Snell, B.W. Kim, C.K. Rha, and A.J. Sinskey. 2001. Increased poly-ß- hydroxybutyrate (PHB) chain length by the modulation of PHA synthase activity in recombinant Escherichia coli. Biotechnol. Lett. 23:2057-2061.
Yuan, W., Y. Jia, J. Tian, K.D. Snell, U. Muh, A.J. Sinskey, R.H. Lambalot, C.T. Walsh, and J. Stubbe. 2001. Class I and III Polyhydroxyalkanoate Synthases from Ralstonia eutropha and Allochromatium vinosum: Characterization and Substrate Specificity Studies. Arch. Biochem. Biophys. 394(1):87-98.
York, G.M., B.H. Junker, J. Stubbe, and A.J. Sinskey. 2001. Accumulation of the PhaP Phasin of Ralstonia eutropha is Dependent on Production of Polyhydroxybutyrate in Cells. J. Bacteriol. 183(14):4217-4226.
Guillouet, S., A.A. Rodal, G.-H. An, N. Gorret, P.A. Lessard, and A.J. Sinskey. 2001. Metabolic redirection of carbon flow toward isoleucine by expressing a catabolic threonine dehydratase in a threonine overproducing Corynebacterium glutamicum. Appl. Microbiol. Biotechnol. 57(5-6):667-673.
Jia, Y., W. Yuan, J. Wodzinska, C. Park, A.J. Sinskey, and J. Stubbe. 2001. Mechanistic Studies on Class I Polyhydroxybutyrate (PHB) Synthase from Ralstonia eutropha: Class I and III Synthases Share a Similar Catalytic Mechanism. Biochemistry 40(4):1011-1019.
York, G.M., J. Stubbe, and A.J. Sinskey. 2001. New Insight into the Role of the PhaP Phasin of Ralstonia eutropha in Promoting Synthesis of Polyhydroxybutyrate. J. Bacteriol. 183(7):2394-2397.
Yanagimachi, K.S., D.E. Stafford, A.F. Dexter, A.J. Sinskey, S. Drew and G. Stephanopoulos. 2001. Application of Radiolabeled Tracers to Biocatalytic Flux Analysis. Eur. J. Biochem. 268(18):4950-4960.
Willis, L.B., P.A. Lessard and A. Sinskey. 2001. Amino Acids. In: Encyclopedia of Genetics. Brenner, S. and Miller, J.H. (eds.), Academic Press: London. pp. 54-56.
Loos, A., C. Glanemann, L. Willis, X. O'Brien, P. Lessard, R. Gerstmeir, S. Guillouet, A.J. Sinskey. 2001. Development and Validation of Corynebacterium DNA Microarrays. Appl. Environ. Microbiol. 67(5):2310-2318.
Lee, S.-P., T.-R. Kim, and A.J. Sinskey. 2000. Cloning and Sequencing of the Gene Involved in Morphological Change of Zoogloea ramigera 115SLR. J. Microbiol. Biotechnol. 10(2):161-168.
Jia, Y., T.J. Kappock, T. Frick, A.J. Sinskey and J. Stubbe. 2000. Lipases provide a new mechanistic model for polyhydroxybutyrate (PHB) synthases: characterization of the functional residues in C. vinosum PHB synthase. J. Biochemistry 39(14):3927-36.
Guillouet, S., P.A. Lessard and A.J. Sinskey. 2000. Investigating Microbial Metabolic Pathways with NMR: Metabolism of Amino Acids in Corynebacteria. In: NMR in Microbiology: Theory and Applications. Barbotin J.N. and Portais, J.C. (eds.), Horizon Scientific Press: Wymondham, UK. pp. 259-281.
Lessard, P.A., X.M. O'Brien, N.A. Ahlgren, S.A. Ribich and A.J. Sinskey. 1999. Characterization of IS1676 from Rhodococcus erythropolis SQ1. Appl. Microbiol. Biotechnol. 52:811-819.
Guillouet, S., A.A. Rodal, G.-H. An, P.A. Lessard and A.J. Sinskey. 1999. Expression of the Escherichia coli catabolic threonine dehydratase in Corynebacterium glutamicum and its effect on isoleucine production. Appl. Environ. Microbiol. 65(7):3100-3107.
An, G.H., K.B. Song and A.J. Sinskey. 1999. Redirection of Carbon Flux to Lysine in a Recombinant of Corynebacterium lactofermentum ATCC 21799 by Limited Supply of Pantothenate. J. Biosci. Bioengr. 88(2):168-172.
Lessard, P.A., S. Guillouet, L.B. Willis and A.J. Sinskey. 1999. Corynebacteria, Brevibacteria. Encyclopedia of Bioprocess Technology: Fermentation, Biocatalysis, and Bioseparation. Flickinger, M.C. and Drew, S.W. (eds.), John Wiley and Sons, Inc.: New York. pp. 729-740.
Treadway, S.L., K.S. Yanagimachi, E. Lankenau, P.A. Lessard, G. Stephanopoulos and A.J. Sinskey. 1999. Isolation and characterization of indene bioconversion genes from Rhodococcus strain I24. Appl. Microbiol. Biotechnol. 51(6):786-793.
Goswami, J., AJ Sinskey, H. Steller, G.N. Stephanopoulos and D.I.C. Wang. 1999. Apoptosis in batch cultures of Chinese hamster ovary cells. Biotechnol. Bioeng. 62(6):632-640.
Shaw-Reid, C.A., M.M. McCormick, A.J. Sinskey, G. Stephanopoulos. 1999. Flux through the tetrahydrodipicolinate succinylase pathway is dispensible for L-lysine production in Corynebacterium glutamicum. Appl. Microbiol. Biotechnol. 51(3):325-333.
Klapa, M.I., S.M. Park, A.J. Sinskey and G. Stephanopoulos. 1999. Metabolite and isotopomer balancing in the analysis of metabolic cycles: I. Theory. Biotechnol. Bioeng. 62(4):375-391.
Park, S.M., M.I. Klapa, A.J. Sinskey and G. Stephanopoulos. 1999. Metabolic and isotopomer balancing in the analysis of metabolic cycles: II. Applications. Biotechnol. Bioeng. 62(4):392-401.
Muh, U., A.J. Sinskey, D.P. Kirby, W.S. Lane and J. Stubbe. 1999. PHA synthase from Chromatium vinosum: cysteine 149 is involved in covalent catalysis. Biochemistry 38(2):826-37.
Dauvillee, D., C. Colleoni, E. Shaw, G. Mouille, C. D'Hulst, M. Morell, M. Samuel, B. Bouchet, D. Gallant, A. Sinskey and S. Ball. 1999. Novel, starch-like polysaccharides are synthesized by an unbound form of granule-bound synthase in glycogen-accumulating mutants of Clamydomanas reinhardtii. Plant Physiology 119(1):321-329.
Guillouet, S., J.H. Choi, C.K. Rha and A.J. Sinskey. 1999. Effects of yeast extract on the production and the quality of the exopolysaccharide, Zooglan, produced by Zoogloea ramigera 115SLR. Appl. Microbiol. Biotechnol. 51:235-240.
Koffas, M.A.G., R. Ramamoorthi, W.A. Pine, A.J. Sinskey and G. Stephanopoulos. 1998. Sequence of the Corynebacterium glutamicum pyruvate carboxylase gene. Appl. Microbiol. Biotechnol. 50(3):346-352.
Chung, J.D., A.J. Sinskey and G. Stephanopoulos. 1998. Growth factor and BCL-2 mediated survival during the abortive proliferation of a hybridoma cell line. Biotechnol. Bioeng. 57(2):164-171.
Sim, S.J., K.D. Snell, S.A. Hogan, J. Stubbe, C. Rha and A.J. Sinskey. 1997. PHA synthase activity controls the molecular weight and polydispersity of polyhydroxybutyrate in vivo. Nat. Biotechnol. 15(1):63-67.
Park, S. M., A.J. Sinskey and G. Stephanopoulos. 1997. Metabolic and physiological studies of Corynebacterium glutamicum mutants. Biotechnol. Bioeng. 55(6):864-879.
Lee, S.P., O.S. Kwon and A.J. Sinskey. 1996. Localization of genes involved in exopolysaccharide biosynthesis in Zooglea ramigera 115SLR. J. Microbiol. Biotechnol. 6(5):321-325.
Ersoy, O., R. Fleck, A.J. Sinskey and S. Masamune. 1996. N O acyl transfer reaction catalyzed by antibodies. J. Am. Chem. Soc. 118:13077-13078.
Wodzinska, J. K. Snell, A. Rhomderg, A. J. Sinskey, K. Biemann and J. Stubbe. 1996. Polyhydroxybutyrate synthase: evidence for covalent catalysis. J. Am. Chem. Soc. 118(26):6319-6320.
Park, S. M., C.A. Shaw-Reid, A.J. Sinskey and G. Stephanopoulos. 1996. Elucidation of anaplerotic pathways in Corynebacterium glutamicum via 13C-NMR spectroscopy and GCMS. Appl Microbiol. Biotechnol. 47(4):430-440.
Chen, K., G. Stephanopoulos, A.J. Sinskey and H.F. Lodish. 1995. Regulated secretion of Prolactin by the mouse insulinoma cell line bTC-3. Biotechnology 13(11):1191-1197.
Kwok, S., S-Y Chang, A.J. Sinskey, and A. Wang. 1995. Design and use of mismatched and degenerate primers. In: Dieffenbach CW, PCR primer: a laboratory manual. Dveksler, G.S. (eds.), Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY. pp. 143-155.
Colón, G.E., T.T. Nguyen, M.S.M. Jetten, A.J. Sinskey and G. Stephanopoulos. 1995. Production of isoleucine by overexpression of ilvA in a Corynebacterium lactofermentum threonine producer. Appl. Microbiol. Biotechnol. 43(3):482-488.
Jetten, M.S.M. and A.J. Sinskey. 1995. Recent advances in the physiology and genetics of amino acid-producing bacteria. Crit. Rev. Biotechnol. 15(1):73-103.
Jetten, M.S.M., M.T. Follettie and A.J. Sinskey. 1995. Effect of different levels of aspartokinase on the lysine production of Corynebacterium lactofermentum. Appl. Microbiol. Biotechnol. 43:76-82.
Zupke, C., A.J. Sinskey and G. Stephanopoulos. 1995. Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas. Appl. Microbiol. Biotechnol. 44(1-2):27-36.
Colón, G.E., S.M. Jetten, T.T. Nguyen, M. Gubler, M.T. Follettie, A.J. Sinskey and G. Stephanopoulos. 1995. Effect of inducible thrB expression on amino acid production in Corynebacterium lactofermentum ATCC 21799. Appl. Environ. Microbiol. 61(1):74-78.
Hwang, C., H.F. Lodish, A.J. Sinskey. 1995. Measurement of glutathione redox state in cytosol and secretory pathway of cultured cells. Methods Enzymol. 251:212-221.
Shelikoff, M., A.J. Sinskey and G. Stephanopoulos. 1994. The effect of protein synthesis inhibitors on the glycosylation site occupancy of recombinant human prolactin. Cytotechnology 15(1-3):195-208.
Suga, H., I.N. Tanimoto, A.J. Sinskey and S. Masamune. 1994. Glycosidase antibodies induced to a half-chair transition-state analog, J. Am. Chem. Soc. 116:11197-11198.
Jetten, M.S. and A.J. Sinskey. 1994. Purification and properties of oxaloacetate decarboxylase from Corynebacterium glutamicum. Antonie van Leeuwenhock 00: 1-7.
Suga, H., O. Ersoy, S.F. Williams, T.Takeshi, M.N. Margolies, A.J. Sinskey and S. Masamune. 1994. Catalytic antibodies generated via heterologous immunization. J. Am. Chem. Soc. 116:6025-6026.
Jetten, M.S., M.E. Gubler, S.H. Lee and A.J. Sinskey. 1994. Structural and functional analysis of pyruvate kinase from Corynebacterium glutamicum. Appl. Environ. Microbiol. 60(7):2501-2507.
Gubler, M., M. Jetten, S.H. Lee and A.J. Sinskey. 1994. Cloning of the pyruvate kinase gene (pyk) of Corynebacterium glutamicum and site-specific inactivation of pyk in a lysine-producing Corynebacterium lactofermentum. Appl. Environ. Microbiol. 60(7):2494-2500.
Gerngross, T.U., K.D. Snell, O.P. Peoples, A.J. Sinskey, E. Csuhai, S. Masamune and J. Stubbe. 1994. Overexpression and purification of the soluble polyhydroxyalkanoate synthase from Alcaligenes eutrophus: Evidence for a required post-translational modification for catalytic activity. Biochemistry 33(31):9311-9320.
Kim, S.K., I.S. Kong, K.J. Kwon, C. Rha, A.J. Sinskey and J.Y. Kong. 1994. Exopolysaccharide produced by Z. ramigera mutants and analysis of structural-change by solution properties. Biotechnol. Letts. 16(8):789-794.
Jetten, M.S.M., G.A. Pitoc, M.T. Follettie and A.J. Sinskey. 1994. Regulation of phosphoenol pyruvate and oxaloacetate converting enzymes in Corynebacterium glutamicum. Appl. Microbiol. Biotechnol. 41:47-52.
Suga, H. O. Ersoy, T. Takeshi, L. Jung, A.J. Sinskey and S. Masamune. 1994. Esterolytic antibodies induced to haptens with a 1,2-Aminoalcohol functionality. J. Am. Chem. Soc. 116:487-494.
Lee, H.-S. and A. J. Sinskey. 1994. Molecular characterization of aceB, a gene encoding malate synthase in Corynebacterium glutamicum. J. Microbiol. Biotechnol. 4:256-263.
Jetten, M.S.M., M.T. Follettie and A.J. Sinskey. 1994. Metabolic engineering of Corynebacterium glutamicum. In: Recombinant DNA Technology II, Bajpai and Prokop (eds.), Proc. N.Y. Acad. Sci. 721:12-29.
Gubler, M., S.M. Park, M. Jetten, G. Stephanopoulos and A.J. Sinskey. 1993. Effects of phosphoenol pyruvate carboxylase deficiency on metabolism and lysine production in Corynebacterium glutamicum. Appl. Microbiol. Biotechnol. 40:857-863.
Gerngross, T.U., P. Reilly, A.J. Sinskey, J. Stubbe and O.P. Peoples. 1993. Immunocytochemical analysis of PHB granules from Alcaligenes eutrophus. J. Bacteriol. 175(16):5289-5293.
Archer, J.A.C. and A.J. Sinskey. 1993. The DNA sequence and minimal replicon of the Corynebacterium glutamicum plasmid pSR1: Evidence of a common ancestry with plasmids from C. diphtheriae. J. Gen. Microbiol. 139:1753-1759.
Jetten, M.S.M., M.E. Gubler, G.E. Colon, M.M. McCormick, M.T. Follettie and A.J. Sinskey. 1993. Molecular organization and regulation of the biosynthetic pathway and aspartate derived amino acids in Corynebacterium glutamicum. In: Proc. of 5th ASM Conference on Genetics and Molecular Biology of Industrial Microorganisms. Baltz, R.H., Hegeman, G.D. and Skatrud, P.L. (eds.), ASM, Washington, DC, Industrial Microorganisms: Basic and Applied Molecular Genetics, pp. 97-104.
Stephanopoulos, G. and A.J. Sinskey. 1993. Metabolic engineering - methodologies and future prospects. Trends Biotechnol. 11(9):392-396.
Jetten, M.S.M. and A.J. Sinskey. 1993. Characterization of phosphoenol pyruvate carboxykinase from Corynebacterium glutamicum. FEMS Microbiol. Lett. 111:183-188.
Follettie, M.T., O.P. Peoples, C. Agoropoulou and A.J. Sinskey. 1993. Gene Structure and Expression of the Corynebacterium flavum N13 ask-asd Operon. J. Bacteriol. 175:4096-4103.
Hwang, C., A.J. Sinskey and H.F. Lodish. 1992. The oxidized potential in the endoplasmic reticulum: Glutathione as the principal redox buffer. Science 257:1496-1502.
Bor, Y.-C., C. Moraes, S.-P. Lee, W.L. Crosby, A.J. Sinskey and C.A. Batt. 1992. Cloning and nucleotide sequence of the Lactobacillus brevis xylose isomerase. Gene 114:127-131.
Williams, S.F., M.A. Palmer, O.P. Peoples, C.T. Walsh, A.J. Sinskey and S. Masamune. 1992. Biosynthetic thiolase from Zoogloea ramigera. Mutagenesis of the putative active site base Cys-378 to Ser-378 changes the partitioning of the acetyl-S-enzyme intermediate. J. Biol. Chem. 267(23):16041-16043.
Jain, J., V.E. Valge-Archer, A.J. Sinskey and A. Rao. 1992. The AP-1 site at -150 bp, but not the NF-kB site, is likely to represent the major target to protein kinase C in the interleukin-2 promoter. J. Exp. Med. 175:853-862.
Liebl, W., A.J. Sinskey and K.-H. Schleifer. 1992. Expression, secretion and processing of staphylococcal nuclease by Corynebacterium glutamicum. J. Bacteriol. 174:1854-1861.
Follettie, M.T., O.P. Peoples, J.A.C. Archer and A.J. Sinskey. 1991. Metabolic engineering of Corynebacteria. Proceedings of the 6th International Symposium on Genetics of Industrial Microorganisms. Vol. 1. pp. 315-325.
Palmer, M.A.J., E. Differding, R. Gamboni, S.F. Williams, O.P. Peoples, C.T. Walsh, A.J. Sinskey and S. Masamune. 1991. Biosynthetic thiolase from Zoogloea ramigera. Evidence for a mechanism involving Cys-378 as the active site base. J. Biol. Chem. 266(13):8369-8375.
Hwang, C. and A.J. Sinskey. 1991. The role of oxidation-reduction potential in monitoring growth of cultured mammalian cells. In: Production of Biologicals from Animal Cells in Culture, Spier, R.E., Griffiths, J.B. and Meignier, B. (eds.), ESACT, Butterworth-Heinemann, pp. 548-568.
Archer, J.A.C., D.E. Solow-Cordero and A.J. Sinskey. 1991. A C-terminal deletion in Corynebacterium glutamicum homoserine dehydrogenase abolishes allosteric inhibition by L-threonine. Gene 107:53-59.
Valge-Archer, V.E., J. de Villiers, A.J. Sinskey and A. Rao. 1990. Transformation of T lymphocytes by the v-fos oncogene. J. Immunol. 145:4355-4364.
Follettie, M.T. and A.J. Sinskey. 1990. Corynebacterium glutamicum - A model for the use of recombinant DNA technology in food grade microorganisms. In: Biotechnology and Food Safety. Bills, D.D. and Kung, S.-D, (eds.), Butterworth-Heinemann: Boston, pp. 277-290.
Peoples, O.P. and A.J. Sinskey. 1990. PHB: A Model System for Biopolymer Engineering II. In: Novel Biodegradable Microbial Polymers. Dawes, E.A. (ed.), Kluwer Academic Publishers: London, vol. 186, pp. 191-202.
Ozaki, A., E.J. Toone, C.H. von der Osten, A.J. Sinskey and G.M. Whitesides. 1990. Overproduction and substrate specificity of a bacterial fuculose-1-phosphate aldolase: A new enzymatic catalyst for stereocontrolled aldol condensation. J. Am. Chem. Soc. 112:4970-4971.
Liebl, W., K.H. Schleifer and A.J. Sinskey. 1990. Secretion of heterologous proteins by Corynebacterium glutamicum. Genetic Transformation and Expression pp. 553-559.
Marcel, T., J.A.C. Archer, D. Mengin-Lecreulx and A.J. Sinskey. 1990. Nucleotide sequence and organization of the upstream region of the Corynebacterium glutamicum lysA gene. Molec. Microbiol. 4(11):1819-1830.
Adema, E., D. Shnek, F. Cahn and A.J. Sinskey. 1990. Use of porous microcarriers in agitated cultures. BioPharm. 3(7):20-24.
Han, K.-S., J.A.C. Archer and A.J. Sinskey. 1990. The molecular structure of the Corynebacterium glutamicum threonine synthase gene. Molec. Microbiol. 4:1693-1702.
von der Osten, C.H., C. Gioannetti, C. Barbas, R.L. Pederson, Yi-F. Wang, C.-H. Wong, A. Ozaki, E. Toone, G.M. Whitesides and A.J. Sinskey. 1990. Molecular cloning of aldolases for synthetic applications. Ann. N.Y. Acad. Sci. (Proc. 10th Enzyme Engineering Conference), Vol. 613, pp. 771-775.
Jamas, S., Y.-C.J. Chen, C.H. von der Osten, A.J. Sinskey and C.K. Rha. 1990. Spectral analysis of glucan produced by wild-type and mutant Saccharomyces cerevisiae. J. Carbohydr. Polym. 13:207-219.
Toone, E.J., Kobori, Y., D.C. Myles, A. Ozaki, W. Schmid, C. von der Osten, A.J. Sinskey and G.M. Whitesides. 1990. Enzymes as catalysts in carbohydrate synthesis. In: Chemical Aspects of Enzyme Biotechnology. Baldwin, T.O. (ed.), Plenum Press: New York, pp. 179-195.
Sambanis, A., G. Stephanopoulos, A.J. Sinskey and H.F. Lodish. 1990. Use of regulated secretion in protein production from animal cells: An evaluation with the AtT-20 model cell line. Biotechnol. Bioeng. 35:771-780.
Eikmanns, B.J., M.T. Follettie, M.U. Griot and A.J. Sinskey. 1989. The phosphoenolpyruvate carboxylase gene of Corynebacterium glutamicum: Molecular cloning, nucleotide sequence, and expression. Mol. Gen. Genet. 218:330-339.
Morimoto, S., M. Matsuo, K. Azuma and A.J. Sinskey. 1989. Purification and properties of D-xylulose reductase from Pachysolen tannophilus. J. Ferment. Technol. 64(3):219-225.
von der Osten, C.H., C.F. Barbas, C.-H. Wong and A.J. Sinskey. 1989. Molecular cloning, nucleotide sequence and fine structural analysis of the Corynebacterium glutamicum fda gene: Structural comparison of C. glutamicum fructose-1,6-biphosphate aldolase to Class I and Class II aldolases. Molec. Microbiol. 3:1625-1638.
Archer, J.A.C., M.T. Follettie and A.J. Sinskey. 1989. Biology of Corynebacterium glutamicum: A Molecular Approach. In: Genetics and Molecular Biology of Industrial Microorganisms. Report on Proceedings. Fourth Conference on Genetics of Industrial Microorganisms, Hershberger, C.L., Queener, S.W. and Hegeman, G., (eds.), American Society for Microbiology, pp. 27-34.
Walsh, C., W.H. Chen, E. Differding, S. Masamune, O. Peoples, O. Ploux, A.J. Sinskey and S. Thompson. 1989. Enzymes in the biosynthesis of polyesters. Proc. Robert A. Walsh Found. Conf. Chem. Res. 31:184-203.
Masamune, S., C.T. Walsh, A.J. Sinskey and O.P. Peoples. 1989. Poly(R)-3-hydroxybutyrate (PHB) biosynthesis: Mechanistic studies on the biological Claisen condensation catalyzed by ß-ketoacyl thiolase. Pure and Appl. Chem. 61:303-312.
Thompson, S., F. Mayer, O.P. Peoples, S. Masamune, A.J. Sinskey and C.T. Walsh. 1989. Mechanistic studies on ß-ketoacyl thiolase from Z. ramigera: Identification of the active-site nucleophile as Cys89, its mutation to Ser89, and kinetic and thermodynamic characterization of wild type and mutant enzymes. Biochemistry 28:5735-5742.
von der Osten, C., C. Gioannetti and A.J. Sinskey. 1989. Design of a defined medium for growth of Corynebacterium glutamicum in which citrate facilitates iron uptake. Biotechnol. Letts. 11:11-16.
Peoples, O.P. and A.J. Sinskey. 1989. Poly-(ß)-hydroxybutyrate biosynthesis in Alcaligenes eutrophus H16: Identification and characterization of the PHB polymerase gene (phbC). J. Biol. Chem. 264:15298-15303.
Peoples, O.P. and A.J. Sinskey. 1989. Poly-(ß)-hydroxybutyrate biosynthesis in Alcaligenes eutrophus H16: Characterization of the genes encoding ß-ketothiolase and acetoacetyl-CoA reductase. J. Biol. Chem. 264(26):15293-15297.
Masamune, S., M.A.J. Palmer, R. Gamboni, S. Thompson, J.T. Davis, S.F. Williams, O.P. Peoples, A.J. Sinskey and C.T. Walsh. 1989. Bio-Claisen condensation catalyzed by thiolase from Zoogloea ramigera. Active site cysteine residues. J. Amer. Chem. Soc. 111:1879-1881.
Glacken, M.W., C. Hwang and A.J. Sinskey. 1989. Mathematical descriptions of hybridoma culture kinetics. III. Simulation of fed-batch bioreactors. J. Biotechnol. 10:39-66.
Von der Osten, C.H., A.J. Sinskey, C.F. Barbas, R.L. Pederson, Y.-F. Wang and C.-H. Wong. 1989. Use of a recombinant bacterial fructose-1,6-diphosphate aldolase in aldol reactions: preparative syntheses of 1-deoxyjirimycin, 1-deoxymannojimycin 1,4-dideoxy-1,4-imino-d-arabinitol and fagomine. J. Amer. Chem. Soc. 111:3924-3927.
Valge, V.E., J. Wong, B.M. Datlof, A.J. Sinskey and A. Rao. 1988. Protein kinase C is required for responses to T cell receptor ligands but not to interleukin 2 in T cells. Cell 55:101-112.
Liebl, W. and A.J. Sinskey. 1988. Molecular cloning and nucleotide sequence of a gene involved in the production of extracellular DNase by Corynebacterium glutamicum. In: Genetics and Biotechnology, Ganesan, A.T. and Hoch, J.A. (eds.), Academic Press: New York, Vol. 2, pp. 383-390.
Peoples, O.P. and A.J. Sinskey. 1988. Fine structural analysis of the Zoogloea ramigera phbA-phbB locus encoding ß-ketothiolase and acetoacetyl-CoA reductase: Nucleotide sequence of phbB. Molec. Microbiol. 3(3):349-357.
Chow, J.J., C.A. Batt and A.J. Sinskey. 1988. Characterization of Lactobacillus bulgaricus bacteriophage ch2. Appl. Environ. Microbiol. 54(5):1138-1142.
Yeh, P., A.M. Sicard and A.J. Sinskey. 1988. General organization of the genes specifically involved in the DAP-lysine pathway of Corynebacterium glutamicum. Mol. Gen. Genet. 212:105-111.
Yeh, P., A.M. Sicard and A.J. Sinskey. 1988. Nucleotide sequence of the LysA gene of Corynebacterium glutamicum and possible mechanism for modulation of expression. Mol. Gen. Genet. 212:112-119.
Follettie, M.T., H.K. Shin and A.J. Sinskey. 1988. Organization and regulation of the Corynebacterium glutamicum hom-thrB and thrC loci. Molec. Microbiol. 2(1):53-62.
Peoples, O.P., W. Liebl, M. Bodis, P.J. Maeng, M.T. Follettie, J.A. Archer and A.J. Sinskey. 1988. Nucleotide sequence and fine structural analysis of the Corynebacterium glutamicum hom-thrB operon. Molec. Microbiol. 2(1):63-72.
Glacken, M.W., E. Adema and A.J. Sinskey. 1988. Mathematical description of hybridoma culture kinetics for optimization of bioreactors: I. Initial metabolic rates. Biotechnol. Bioeng. 32:491-506.
Glacken, M.W., E. Adema and A.J. Sinskey. 1988. Mathematical descriptions of hybridoma culture kinetics: II. The relationship between thiol chemistry and the degradation of serum activity. Biotech. Bioeng. 33:440-451.
Easson, D.D., Jr., Peoples, O.P. and Sinskey, A.J. 1987. Biopolymer Engineering: Genetic Control of Exopolysaccharide Biosynthesis. Presented at Symposium on Modification and Applications of Industrial Polysaccharides. 193rd ACS National Meeting, Denver, Colorado, April 5-10, 1987.
Peoples, O.P. and A.J. Sinskey. 1987. Polyhydroxybutyrate (PHB): A model system for biopolymer engineering. Prog. Biotechnol. 3:51-56.
Jamas, S., C.K. Rha and A.J. Sinskey. 1987. Tailoring of Yeast ß-Glucans by Strain Selection. In: Industrial Polysaccharides: The Impact of Biotechnology and Advanced Methodologies. Stivala, S.S., Crescenzi, V. and Dea, I.C.M. (eds.), Gordon and Breach: New York, pp. 35-44.
Easson, D.D. Jr., A.J. Sinskey and O.P. Peoples. 1987. Isolation of Zoogloea ramigera I-16-M exopolysaccharide biosynthetic genes and evidence for instability within this region. J. Bacteriol. 169:4518-4524.
Liebl, W. and A.J. Sinskey. 1987. Molecular cloning and nucleotide sequence of a gene involved in the production of extracellular DNase by Corynebacterium glutamicum. Proceedings of the Fourth International Conference on Bacilli, San Diego, CA. June 21-24, 1987.
Morimoto, S., T. Tawaratani, K. Azuma and A.J. Sinskey. 1987. Purification and properties of D-xylulose reductase from Pachysolen tannophilus. J. Ferment. Tech. 65(1):17-21.
Sinskey, A.J. and C.A. Batt. 1987. Fungi as a Source of Protein. In: Food and Beverage Mycology, Beuchat, L.R., (ed.), 2nd Edition. Van Nostrand Reinhold: New York, pp. 435-467.
Batt, C.A. and A.J. Sinskey. 1987. Single-Cell Protein. In: Food Biotechnology, D.E. Knorr (ed.), Marcel Dekker, Inc., pp. 347-362.
Davis, J.T., R.N. Moore, B. Imperiali, A. Pratt, K. Kobayashi, S. Masamune, A.J. Sinskey and C.T. Walsh. 1987. Biosynthetic thiolase from Zoogloea ramigera. 1. Preliminary characterization and analysis of proton transfer reaction. J. Biol. Chem. 262(1):82-89.
Davis, J.T., J.-H. Chen, S. Masamune, A.J. Sinskey and C.T. Walsh. 1987. Biosynthetic thiolase from Zoogloea ramigera. 2. Inactivation with haloacetyl CoA analogs. J. Biol. Chem. 262(1):90-96.
Peoples, O.P., S. Masmune, C.T. Walsh and A.J. Sinskey. 1987. Biosynthetic Thiolase from Zoogloea ramigera. 3. Isolation and Characterization of the Structural Gene. J. Biol. Chem. 262(1):97-102.
Adema, E. and A.J. Sinskey. 1987. Analysis of Intra vs. Extra Capillary Growth in a Hollow-Fiber Reactor. Biotech. Prog. 3:74-79.
Follettie, M.T., P. Yeh, H.K. Shin, O.P. Peoples, K.S. Han and A.J. Sinskey. 1986. Development of recombinant DNA technology for Corynebacterium glutamicum: Isolation and characterization of amino acid biosynthetic genes. In: Genetics of Industrial Microorganisms. Proceedings of the Fifth International Symposium on the Genetics of Industrial Microorganisms. Alacevic, M., Hranueli, D. and Toman, Z. (eds.), pp. 239-247.
Follettie, M.T. and A.J. Sinskey. 1986. Recombinant DNA technology for Corynebacterium glutamicum. Food Technol. 40:88-94.
Follettie, M.T. and A.J. Sinskey. 1986. Molecular cloning and nucleotide sequence of the Corynebacterium glutamicum pheA gene. J. Bacteriol. 167(2):695-702.
Morimoto, S., M. Matsuo, K. Azuma and A.J. Sinskey. 1986. Purification and properties of D-xylulose reductase from Pachysolen tannophilus. J. Ferment. Tech. 64(3):219-225.
Sinskey, A.J. 1986. Biotecnologia. In: Los Paises Industrializados Ante las Nuevas Tecnologias. II. Experiencias tecnologicas e impactos economicos y sociales. Barbera, J., Gamella, M., Ros F. and Valle, R. (eds.), pp. 49-59.
Glacken, M.W., R.J. Fleischaker and A.J. Sinskey. 1986. Reduction of waste product excretion via nutrient control: Possible strategies for maximized product and cell lysis on serum in cultures of mammalian cells. Biotechnol. Bioeng. 28:1376-1389.
Jamas, S., C.K. Rha and A.J. Sinskey. 1986. Morphology of yeast cell wall as affected by genetic manipulation of ß(1T6) glycosidic linkage. Biotechnol. Bioeng. 28:769-784.
Sinskey, A.J., D.D. Easson, Jr., S. Jamas and C. Rha. 1986. Biopolymers and Modified Polysaccharides. In: Biotechnology in Food Processing ,S.K. Harlander and T.P. Labuza (eds.), Noyes Publication, Park Ridge, New Jersey, pp. 73-114.
Easson, D.D., Jr., O.P. Peoples, C.K. Rha and A.J. Sinskey. 1986. Engineering of Biopolymer Flocculants: A Recombinant DNA Approach. In: Symposium on Flocculation in Biotechnology and Separation Systems , Attia Y.A. (ed.), Elsevier, Amsterdam, pp. 369-381.
Knorr, D. and A.J. Sinskey. 1985. Biotechnology in food production and processing. Science. 229(4719):1224-1229.
Batt, C., M. Follettie, H. Shin, P. Yeh and A.J. Sinskey. 1985. Genetic engineering of coryneform bacteria. Trends Biotechnol. 3:305-310.
Yoshihama, M., K. Higashio, E.A. Rao, M. Akedo, W.G. Shanabruch, M.T. Follettie, G.C. Walker and A.J. Sinskey. 1985. A cloning vector system for Corynebacterium glutamicum. J. Bacteriol. 162:592-597.
Batt, C.A., W.S. Shanabruch and A.J. Sinskey. 1985. Expression of pAMa1 tetracycline resistance gene in Corynebacterium glutamicum. Segregation of antibiotic resistance due to intermolecular recombination. Biotech. Letts. 7(10):717-722.
Batt, C.A., M.C. Claps, M.S. Bodis, S. Jamas and A.J. Sinskey. 1985. Analysis of xylose operon regulation by Mud-lac fusion: Trans effect of plasmid coded xylose operon. Canadian J. Microbiol. 31(10):930-933.
Batt, C.A., S. Carvallo, D.D. Easson and A.J. Sinskey. 1985. Evidence for a xylose metabolic pathway in Saccharomyces cerevisiae. Biotechnol. Bioeng. 28:549-553.
Sinskey, A.J. 1984. An Overview of Biotechnology: Current and Future Status. In: Biotechnology in the Americas: Prospects for Developing Countries. Sawyer, W.D. (ed.), Proceeding of a Symposium held in San Jose, Costa Rica. May 3, 1983. pp. 9-16.
Batt, C.A. and A.J. Sinskey. 1984. Current Status of genetic engineering of Lactobacillus. Presented at the Symposium on the Importance of Lactic Acid Fermentation on the Food Industry. November 26-29, 1984, Mexico.
Pellon, J.R. and A.J. Sinskey. 1984. Heat-Induced Damage to the Bacterial Chromosome and its Repair. In: The Revival of Injured Microbes. Andrew, M.H.E. and Russell, A.D. (eds.), Academic Press, pp. 105-122.
Colwell, R.R., E.R. Pariser and A.J. Sinskey (eds.). 1984. Biotechnology in the Marine Sciences. Proceeding of the First Annual MIT Sea Grant Lecture and Seminar. John Wiley and Sons, New York.
Glacken, M.W., R.J. Fleischaker and A.J. Sinskey. 1984. Large-scale production of mammalian cells and their products: Engineering principles and barriers to scale-up. Anal. N.Y. Acad. Sci. 413:355-372.
Batt, C.A. and A.J. Sinskey. 1984. Use of Biotechnology in the Production of SCP. Food Technol. 108-111.
Sinskey, A.J. 1983. Organic Chemicals From Biomass: An Overview. In: Organic Chemicals from Biomass, Ed. Wise, D.L., California, Benjamin/Cummings Publishing Co., pp. 1-66.
Pellon, J.R. and A.J. Sinskey. 1983. Genetic Engineering for Food and Additives, In: Food Microbiology: Advances and Prospects. Roberts, T.A. and Skinner, F.A. (eds.), Academic Press: New York, pp. 287-299.
Glacken, M.W., R.J. Fleischaker and A.J. Sinskey. 1983. Mammalian cell culture: Engineering principles and scale-up. Trends Biotechnol. 1:102-109.
Pellon, J.R. and A.J. Sinskey. 1983. A note on the repair of Escherichia coli nucleoid structure after heat shock. J. Appl. Bacteriol. 54:437-439.
Akedo, M., C.L. Cooney and A.J. Sinskey. 1983. Direct Evidence for Lactate-Acrylate Interconversion in Clostridium propionicum. Bio/Technology 1:791-794.
Pellon, J.R. and A.J. Sinskey. 1983. Genetic Engineering for Food and Additives. In: Food Microbiology: Advances and Prospects. Skinner, F.A. and Roberts, T.A. (eds.), Academic Press, pp. 287-300.
Awerbuch, T.E. and A.J. Sinskey. 1983. The Effect of Different Genetic Properties of Salmonella typhimurium on the Determination of Stabilities and Mutagenic Concentrations of Chemical Carcinogens Using the Diffusion Bioassay. Mutation Res. 113:13-19.
Pellon, J.R., A.J. Sinskey, S.M. Hecht and R.F. Gomez. 1983. Kinetics of Bleomycin A2 Damage in vivo to the Folded Chromosome of Escherichia coli. Chem. Biol. Interactions 43:245-251.
Schaffeld, G., A.J. Sinskey and C. Rha. 1982. Release of Single-Cell Protein by Induced Cell Lysis. J. Food Sci. 47:2072-2073.
Pellon, J.R., R.F. Gomez and A.J. Sinskey. 1982. Association of the Escherichia coli Nucleoid with Protein Synthesized During Thermal Treatments. In: Heat Shock: From Bacteria to Man. Schlesinger, M.J., Ashburner, M., Tissieres, A. (eds.), Cold Spring Harbor Laboratories: New York, pp. 121-125.
Giard, D., R. Fleischaker and A.J. Sinskey. 1982. Kinetics of human beta interferon production under different temperature conditions. J. Interferon Res., Vol. 2., No. 4, pp. 471-477.
Ibe, S.N., A.J. Sinskey and D. Botstein. 1982. Genetic Mapping of Mutations of a Highly Radiation-Resistant Mutant of Salmonella typhimurium LT2. J. Bact. 152:260-268.
Sinskey, A.J. 1981. Chapter 5: Mode of Action and Effective Application. In: Developments in Food Preservatives - 1. Tilbury, R.H. (ed.), Applied Science Publishers, Barking: Essex, England, pp. 111-136.
Fleischaker, R.J. and A.J. Sinskey. 1981. Oxygen demand and supply in cell culture. Eur. J. Appl. Microbiol. Biotechnol. 12:193-197.
Sinskey, A.J., M. Akedo and C.L. Cooney. 1981. Acrylate Fermentations. In: Trends in the Biology of Fermentations for Fuels and Chemicals. Hollaender, A. (ed.), Plenum: New York, pp. 473-492.
Giard, D.J., R.J. Fleischaker, A.J. Sinskey and D.I.C. Wang. 1981. Large-Scale Production of Human Fibroblast Interferon. In: Developments in Industrial Microbiology. Underkofler L.A. and Wulf, M.I. (eds.), Vol. 22, Proc. 37th General Meeting of the Society for Industrial Microbiology, Flagstaff, Arizona, August 9-15, 1980. Arlington, VA., pp. 299-309.
Yorifuji, T. and A.J. Sinskey. 1980. n-Alkane Oxidation Activity in Saccharomycopsis lipolytica NRR1 Y 1094. In: Proceedings of the US/USSR Joint Working Group on Scientific and Technical Cooperation on the Production of Substances by Microbiological Means, "Fundamentals of Microbial Processes," held October 29-31, 1979, at M.I.T., Cambridge, MA.
Fleischaker, R.J., J.C. Weaver and A.J. Sinskey. 1980. Instrumentation for Process Control in Cell Culture. Adv. Appl. Microbiology 27:137-167.
Sinskey, A.J. and R.F. Gomez. 1980. Use of Prokaryotic and Eukaryotic Culture Systems for Examining Biological Activity of Food Constituents. In: Food and Health: Science and Technology. Birch G.G and Parker, K.J. (eds.), Applied Science Publishers: London, pp. 251-286.
Akedo, M., C.L. Cooney and A.J. Sinskey. 1980. Bioconversion of Propionate to Acrylate by Clostridium propionicum. Vol. II. Fuels, Chemicals and Waste Treatment. Moo-Young, M. (ed.), Pergamon Press, Proceedings of the 6th International Synposium, London, Canada, July 1980, pp. 91-96.
Miyasaka, Y., C. Rha and A.J. Sinskey. 1980. Application of Temperature-Sensitive Mutants for Single-Cell Protein Production. Biotechnol. Bioeng. 22(10):2065-2079.
Fleischaker, R.J., D.J. Giard, J. Weaver and A.J. Sinskey. 1980. Progress with Computer-Coupled Mammalian Cell Culture Investigations. In: Advances in Biotechnology, Vol. I., Scientific Eng. Principles. Moo-Young, M. (ed.), Pergamon Press, Proceedings of the 6th International Symposium, London, Canada, July 1980, pp. 425-430.
Dalal, R.K., M. Akedo, C.L. Cooney and A.J. Sinskey. 1980. A microbial route for acrylic acid production. Biosources Digest 2(2):89-97.
Miyasaka, Y., A.J. Sinskey, J. DeAngelo and C. Rha. 1980. Characterization of a morphological mutant of Saccharomyces cerevisiae for single-cell protein production. J. Food Sci. 45(3):558-563.
Sinskey, A.J., R.J. Fleischaker, M.A. Tyo, D.J. Giard and D.I.C. Wang. 1980. Production of cell derived products: Virus and interferon. Ann. New York Acad. Sciences 369:47-59.
Trump, J.G., E.W. Merrill, A.J. Sinskey, K.A. Wright, T.G. Metcalf and D.N. Shah. 1980. Destruction of Pathogenic Microorganisms and Toxic Chemicals by Electron Treatment. In: Proceedings of the Eighth National Conference and Exhibition on Municipal Sludge Management, Miami Beach, Florida, March 22-23, 1979.
Sinskey, A.J. 1979. Preservatives Added to Foods. In: Nutritional and Safety Aspects of Food Processing. Tannenbaum S.R. (ed.), Marcel Dekker Publisher: New York, pp. 369-398.
Awerbuch, T.E. and A.J. Sinskey. 1979. Quantitative determination of half-lifetimes and mutagenic concentrations of chemical carcinogens using a diffusion bioassay. Mut. Res. 74:125-143.
Sasajima, K.-I. and A.J. Sinskey. 1979. Oxidation of L-glucose by a Pseudomonad. Biochim. Biophys. Acta 571:120-126.
Lee, C.-H., T.J. Montville and A.J. Sinskey. 1979. Comparison of the efficacy of steam sterilization indicators. Appl. Environ. Microbiol. 37:1113-1117.
Awerbuch, T., T. Samson and A.J. Sinskey. 1979. A quantitative model of diffusion bioassays. J. Theoret. Biol. 79:333-340.
Ulmer, K.M., R.F. Gomez and A.J. Sinskey. 1979. Ionizing radiation damage to the folded chromosome of Escherichia coli k-12. II. repair of double-strand breaks in DNA. J. Bacteriol. 138:486-491.
Ulmer, K.M., R.F. Gomez and A.J. Sinskey. 1979. Ionizing radiation damage to the folded chromosome of Escherichia coli K-12. I. Sedimentation properties of irradiated nucleoids and chromosomal DNA. J. Bacteriol. 138:475-484.
Boudrant, J., J. DeAngelo, A.J. Sinskey and S.R. Tannenbaum. 1979. Genetic manipulation of single-cell protein. Process characteristics of cell lysis mutants of Saccharomyces cerevisiae. Biotechnol. Bioeng. 21:659-670.
Sinskey, A.J. 1978. Enteropathogenic Escherichia coli: Epidemiology, Significance and Genetics of Toxicology, Republic of China/USA Food Safety Workshop, Taiwan, September 12-15, 1978, Proceedings, pp. 42-82.
Sinskey, A.J. 1978. Fungi as a Source of Protein. In: Food and Beverage Mycology. Beuchat, L.R. (ed.), Avi Publishing Co.: Westport, CT., Chapter 12, pp. 334-367.
Montville, T.J., C.L. Cooney and A.J. Sinskey. 1978. Streptococcus mutans dextransucrase: A review. Advances Appl. Microbiol. 24:55-84.
Sinskey, A.J., J. Boudrant, C. Lee, J. DeAngelo, Y. Miyasaka, C. Rha and S.R. Tannenbaum. 1978. Applications of Temperature-Sensitive Mutants for Single-Cell Protein Production. Proceedings of US/USSR Conference on Mechanisms and Kinetics of Uptake and Utilization of Substrates in Processes for the Production of Single Cell Protein, Moscow-Pushchino, June 4-11, 1977, PB-283-330-T, pp. 362-383. (US/USSR Joint Group on the Production of Substances by Microbiological Means.)
Sinskey, A.J. 1977. High energy electron irradiation of wastewater liquid residuals. Process Biochemistry 12(5):11-14, 32.
Silverman, G.J. and A.J. Sinskey. 1977. Sterilization by Ionizing Radiation. In: Disinfection, Sterilization and Preservation. Block, S.S. (ed.), 2nd edition, Lea and Febiger: Philadelphia, PA., pp. 542-561.
Akedo, M., A.J. Sinskey and R. Gomez. 1977. Antimicrobial action of aliphatic diols and their esters. J. Food Sci. 42:699-701, 706.
Zapatka, F.A., G.W. Varney and A.J. Sinskey. 1977. Reversal by casein of the bactericidal effect of cocoa powder by Salmonellae. J. Appl. Bacteriol. 42:21-27.
Montville, T.J., C.L. Cooney and A.J. Sinskey. 1977. Measurement and synthesis of insoluble and soluble dextran by Streptococcus mutans. J. Dental Res. 56(8):983-989.
Sinskey, A.J., D. Shah and T.J. Metcalf. 1977. Biological Effects of Irradiation with High Energy Electrons. In: Proceedings of the Third National Conference on Sludge Management Disposal and Utilization, Miami Beach, Florida, December 14-16, 1976. Information Transfer, Inc., Rockville, MD., pp. 160-163.
Trump, J.G., K.A. Wright, J.L. Danforth, E.W. Merrill, A.J. Sinskey, T.G. Metcalf, R. Coomeau, D.N. Shah, B. deBree and R. Emanuelson. 1977. Experience at Deer Island with Electron Disinfection of Sludge at High Flow Rates. In: Proceedings Second Internatl. Conference of ESNA Working Group on Waste Irradiation, Uppsala, Sweden, Aug. 31-Sept. 2, 1977, pp. 73-89.
Montville, T.J., C.L. Cooney, A.J. Sinskey. 1977. Distribution of Dextransucrase in Streptococcus mutans and Observations on the Effect of Soluble Dextran on Dextransucrase Activities. Infect. Immun. 18(3):629-635.
Zapataka, F.A., G.W. Varney, A.J. Sinskey. 1977. Distribution of the Bacterial Effect of Cocoa Powder on Salmonellae by Casein. J. Appl. Bacteriol. 42(1):21-25.
Sinskey, A.J. 1976. New Developments in Intermediate Moisture Foods: Humectants. In: Intermediate Moisture Foods, ed. R. Davies, G.G. Birch and K.R. Parker. Applied Science Publishers, London, Paper 18, pp. 260-277.
Cooney, C.L., J. Leung and A.J. Sinskey. 1976. Growth and Physiology of Streptococcus mutans During Transients in Continuous Culture. In: Microbial Aspects of Dental Caries. Stiles, H.M., Loesche, W.J. and O'Brien, T.C. (eds.), Spec. Suppl. Microbiol. Absts. - Bacteriol., Vol. 3, Information Retrieval, Inc.: Arlington, VA., pp. 799-807.
Ordal, Z.J., J.J. Iandola, B. Ray and A.J. Sinskey. 1976. Detection and Enumeration of Injured Microorganisms. In: Compendium of Methods for the Microbiological Examination of Foods. Speck, M.L. (ed.), American Public Health Association: Washington, D.C., pp. 163-169.
White, G.E., C.L. Cooney, A.J. Sinskey and S.A. Miller. 1976. Continuous culture studies on the growth and physiology of Streptococcus mutans. J. Dental Res. 55:239-244.
Gomez, R.F., K.D. Blais, A. Herrero and A.J. Sinskey. 1976. Effects of some inhibitors of protein, RNA and DNA synthesis on heat injured Salmonella typhimurium. J. Gen. Microbiol. 97:19-27.
Baldwin, J.E., S.E. Branz, R.F. Gomez, P.L. Draft, A.J. Sinskey and S.R. Tannenbaum. 1976. Chemical activation of nitrosamines into mutagenic agents. Tetrahedron Letters, 5:333-336.
Lemke, H.S. and A.J. Sinskey. 1975. Viruses and ionizing radiation in respect to waste water treatment. Proc. Internat. Atomic Energy Agency Sm 194/203. pp. 99-120.
Sinskey, A.J. and S.R. Tannenbaum. 1975. Removal of Nucleic Acids in SCP. In: Single-Cell Protein II. Tannenbaum, S.R. and Wang, D.I.C. (eds.), M.I.T. Press: Cambridge, MA, pp. 158-179.
Takano, M., A.J. Sinskey and D. Baraldi. 1975. DNA Damage in Salmonella typhimurium LT-2 by a Combination of Freezing and Nutrition. I.I.F.-I.I.R., Commission C1, Sappror 1973-1975, pp. 61-70.
Trump, J.G., K.A. Wright, A.J. Sinskey, E.W. Merrill and D.N. Shah. 1975. Feasibility of High-Energy Electron Irradiation of Municipal Sludge. In: Water - 1975. Bennett, G.F. (ed.), American Institute of Chemical Engineers Symposium Series, Vol. 71, 367-374.
Imada, A., J.W. Hunt, H. VandeSande, A.J. Sinskey and S.R. Tannenbaum. 1975. Purification and properties of an intracellular ribonuclease from Candida lipolytica. Biochim Biophys. Acta 395:490-500.
Trump, J.G., K.A. Wright, E.W. Merrill, A.J. Sinskey, D. Shah and S. Somer. 1975. Prospects for high energy electron irradiation of waste-water liquid residuals. Proc. Internat. Atomic Energy Agency SM 194/503.
Sinskey, A.J., D. Shah, K.A. Wright, B.W. Merrill, S. Sommer and J.G. Trump. 1975. Biological effects of high energy electron irradiation of municipal sludge. Proc. Internat. Atomic Energy Agency SM194/302, pp. 139-149.
Gomez, R.F. and A.J. Sinskey. 1974. Effect of aeration on minimal medium recovery of heated Salmonella typhimurium LT-2. J. Bacteriol. 122(1):106-109.
Gomez, R. and A.J. Sinskey. 1974. Deoxyribonucleic acid breaks in rifampin treated Salmonella typhimurium LT-2 after exposure to nutritionally complex media. Nature 247:211-212.
Kimble, C.E., P.A. Gorczyca and A.J. Sinskey. 1974. Repair of lesions induced in human liver cell DNA by N-nitroso compounds as measured by the bromo-deoxyruidine phtolysis methods. Mut. Res. 24:35-39.
Gomez, R.R., M. Johnston and A.J. Sinskey. 1974. Characteristics of freeze-dried cells. Cryobiology 10(5):368-374.
White, G.E., C.L. Cooney, A.J. Sinskey and S.A. Miller. 1974. A defined continuous culture medium for Streptococcus mutans. J. Dental Res. 63:762.
Tannenbaum, S.R., A.J. Sinskey, M. Weisman and W. Bishop. 1974. Nitrite in human saliva. Its possible relationship to nitrosamine formation. J. Nat. Cancer Inst. 53(1):79-84.
White, G.E., C.L. Cooney, A.J. Sinskey and S.A. Miller. 1974. An in vitro assay to measure early calcium loss from surface enamel. J. Dental Res. 53(2):481-485.
Augenstein, D.C., K. Thrasher, A.J. Sinskey and D.I.C. Wang. 1974. Optimization in the recovery of a labile intracellular enzyme. Biotechnol. Bioeng. 160:1433-1447.
Gomez, R.F., M. Johnston, A.J. Sinskey. 1974. Activation of Nitrosomorpholine and Nitrosopyrrolidine to Bacterial Mutagens. Mutat Res. 24(1):5-7.
Gomez, R.F. and A.J. Sinskey. 1973. Deoxyribonucleic acid breaks in heated Salmonella typhimurium LT-2 after exposure to nutritionally complex media. J. Bacteriol. 115(2):522-529.
Davies, R. and A.J. Sinskey. 1973. Radiation resistant mutants of Salmonella typhimurium LT2: Development and characterization. J. Bacteriol. 113(1):133-144.
Davies, R., A.J. Sinskey and D. Botstein. 1973. DNA repair in a highly radiation-resistant strain of Salmonella typhimurium. J. Bacteriol. 114(1):357-366.
Plitman, M., Y. Park, A.J. Sinskey and R. Gomez. 1973. Viability of Staphylococcus aureus in intermediate moisture foods. J. Food Sci. 38:1004-1008.
Gomez, R., R. Davies, A.J. Sinskey and T.P. Labuza. 1973. Minimal recovery of heated Salmonella typhimurium LT2. J. Gen. Microbiol. 74:267-274.
Imada, A., A.J. Sinskey and S.R. Tannenbaum. 1972. A new macromolecular inhibitor of yeast ribonuclease mediated through purine nucleotides. Biochim. Biophys. Acta 268:674-679.
Imada, A., A.J. Sinskey and S.R. Tannenbaum. 1972. Ribonucleic Acid Degradation in Candida lipolytica. In: Proc. 4th Internat. Fermentation Symposium, Ferment. Technol. Today, pp. 455-461.
Labuza, T.P., K.A., Jones, A.J. Sinskey, R. Gomez, S. Wilson and B. Miller. 1972. The effect of drying conditions on cell viability and functional properties of single cell protein. J. Food Sci. 37(1):103-107.
Sinskey, A.J. 1971. Current status of injury in freeze-dried microorganisms. J. Milk and Food Technol. 34(11):551-552.
Sinskey, A.J., G.C.Y. Chu and D.I.C. Wang. 1971. Concentration and Purification of Viruses by Ultrafiltration. In: Foods and Bioengineering - Fundamental and Industrial Aspects, B. Lawrence and E.J. Koval, eds., Chemical Engineering Progress Series, A.I.Ch.E., Volume 67, No. 108: pp. 75-80.
Augenstein, D.C., A.J. Sinskey and D.I.C. Wang. 1971. Effect of shear on the death of two strains of mammalian tissue cells. Biotechnol. Bioeng. 13:409-418.
Labuza, T.P., S. Cassil and A.J. Sinskey. 1971. Stability of intermediate moisture foods. 2. Microbiology. J. Food Sci. 37(1): 154-159.
Imada, A., A.J. Sinskey and S.R. Tannenbaum. 1971. Degradation of ribonucleic acid in Candida lipolytica: Extraction of ribonucleic acid degrading enzymes. Biotechnol. Bioeng. 14:103-122.
Castro, A.C., A.J. Sinskey and S.R. Tannenbaum. 1971. Reduction of nucleic acid content in Candida yeast cells by bovine pancreatic ribonuclease a treatment. Appl. Microbiol. 22(3):422-427.
Ohta, S., S. Maul, A.J. Sinskey and S.R. Tannenbaum. 1971. Characterization of heat-shock for reduction of the nucleic acid content of Candida utilis. Appl. Microbiol. 22(3):415-421.
Lewicki, P.P. and A.J. Sinskey. 1970. Precision of RNA separation by polyacrylamide gel electrophoresis. Analyt. Biochem. 33(2):273-278.
Sinskey, A.J. and G.J. Silverman. 1970. Characterization of injury to Escherichia coli ML30 incurred upon freeze-drying. J. Bacteriol. 101(2):429-437.
13. Wang, D.I.C. and A.J. Sinskey. 1970. Collection of Microbial Cells. In: Advances in Applied Microbiology. Academic Press: New York, Volume 12, pp. 121-152.
Wang, D.I.C., A.J. Sinskey and T. Butterworth. 1970. Enzyme Processing Using Ultrafiltration Membranes. In: Membrane Science and Technology. Flinn, J.E. (ed.), Plenum Press: New York, pp. 98-119.
Butterworth, T.A., D.I.C. Wang and A.J. Sinskey. 1970. Application of ultrafiltration for enzyme retention during continuous enzymatic reaction. Biotechnol. Bioeng. 12:615-631.
Maul, S., A.J. Sinskey and S.R. Tannenbaum. 1970. A new process for reducing the nucleic acid content of yeast. Nature 228:181.
Morhart, R.E., L.J. Mata, A.J. Sinskey and R.S. Harris. 1970. A microbiological and biochemical study of gingival crevice debris obtained from Guatemalan Mayan Indians. J. Periodontology - Periodontics 41(11):644-649.
Wang, D.I.C., A.J. Sinskey and P. Sonoyama. 1969. Recovery of biological materials through ultrafiltration. Biotechnol. Bioeng. 11:987-1003.
Chang, R.S. and A.J. Sinskey. 1968. Observations on the transformation of human amnion cell cultures by the SV40. J. Natl. Cancer Institute 40:505-512.
Silverman, G.J. and A.J. Sinskey. 1968. The Destruction of Microorganisms by Ionizing Radiation. In: Antiseptic Disinfectants, Fungicides and Chemical and Physical Sterilization. 3rd edition, Block, S.S. and Lawrence, C.A. (eds.), Lea and Febiger Publishers: Philadelphia, PA. Chapter 44, pp. 741-761.
Wang, D.I.C., A.J. Sinskey, R. Gerner and R.P. deFillippi. 1968. Effect of centrifugation of the viability of Burkett's lymphoma cells. Biotech. Bioeng. 10:641-649.
Pablo, I.S., A.J. Sinskey and G.J. Silverman. 1967. The selection of microorganisms due to freeze-drying. Food Technology 21(5):64-70.
Sinskey, A.J., G.J. Silverman and S.A. Goldblith. 1967. Influence of platen temperatures and relative humidity during storage on the survival of Salmonella typhimurium in freeze-dried model systems. Appl. Microbiol. 15(1):22-30.
Sinskey, A.J., I.S. Pablo, G.J. Silverman and L. Ronsivalli. 1967. The effect of packaging on the major microbial flora of irradiated haddock. Nature 213(5074):425-426.
Sinskey, A.J., A.H. McIntosh, I.S. Pablo, G.J. Silverman and S.A. Goldblith. 1964. Considerations in the recovery of microorganisms from freeze-dried foods. Health Laboratory Science 1:297-306.