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MIT Course Catalog 2013-2014

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Microbiology Graduate Program

Doctoral Program in Microbial Science and Engineering

The study of microbes has been critical in our current understanding of basic biological processes, evolution, and the functions of the biosphere, and has contributed to numerous fields of engineering. Microbes have the amazing ability to grow in extreme conditions, to grow slowly or rapidly, and to readily exchange DNA. They are essential for life as we know it, but can also be agents of disease. They are instrumental in shaping the environment, in evolution, and in modern biotechnology. Microbes are amenable to virtually all modern approaches in science and engineering. As such, they provide natural engineering laboratories for creating new capabilities for industry (e.g., pharmaceuticals, chemicals, energy) and are the foundation of pioneering efforts in synthetic biology, i.e., building life from its component parts. Effective study of microbes and their applications demands multiple interdisciplinary approaches that cross all scales of biological organization, from molecules to vast ecosystems.

Research in microbiology is going on throughout MIT and involves more than 50 faculty. These faculty are from several departments in both the Schools of Science and Engineering, including Biology; Biological Engineering; Chemical Engineering; Chemistry; Civil and Environmental Engineering; Earth, Atmospheric and Planetary Sciences; Electrical Engineering and Computer Science; Materials Sciences and Engineering; and Physics. Many labs take multiple approaches to studying and manipulating microbial systems and the expertise and research covers a wide range of areas, including biochemistry, biotechnology, cell and molecular biology, chemical and biological engineering, computational biology, ecology, environmental biology, evolutionary biology, genetics, genomics, geobiology, immunology, pathogenesis, structural biology, synthetic biology, systems biology, and virology.

The Microbiology Graduate Program—an interdepartmental and interdisciplinary initiative at MIT—integrates educational resources across the participating departments to build connections among faculty with shared interests and to build an educational community for training students in the study of microbial systems.

Interdisciplinary training in microbiology is in increasing demand in both public and private sectors. This program provides a broad exposure to underlying elements of modern microbiological research and engineering as well as in-depth research experience in specific areas of microbiology. Program graduates will be prepared to work in a range of fields in microbial science and engineering, and will have excellent career options in academia, industry, and government.

Curriculum

The major components of the training program are required coursework, elective coursework, rotations and thesis research, teaching, training in the ethical conduct of research, and qualifying exams.

Required Subjects

7.492J Methods and Problems in Microbiology
7.493J Microbial Genetics and Evolution
7.499 Research Rotations in Microbiology
7.57 Quantitative Biology for Graduate Students
 
One of the following biochemistry subjects:
7.51 Principles of Biochemical Analysis
or
7.80 Biological Chemistry II

 

Elective Subjects

Students must take three elective subjects, totaling 36 units, from the following list. Electives can be chosen to provide depth in a specific area of interest or additional breadth in training. Subjects from some other areas may also fulfill the requirement, with the approval of the Graduate Education committee.

1.89 Environmental Microbiology
5.062 Principles of Bioinorganic Chemistry
5.451 Chemistry of Biomolecules and Natural Product Pathways
5.50 Enzymes: Structure and Function
5.52 Advanced Biological Chemistry
5.55 Chemical Tools for Assessing Biological Function
5.64 Biophysical Chemistry
5.65 Molecular Imaging
5.78 Biophysical Chemistry Techniques
6.581J/20.482J Foundations of Algorithms and Computational Techniques in Systems Biology
6.874 Computational Systems Biology
7.26/7.66 Molecular Basis of Infectious Disease
7.56 Foundations of Cell Biology
7.58 Molecular Biology
7.62 Microbial Physiology
7.63 Immunology
7.70 Regulation of Gene Expression
7.75J/5.77J Topics in Metabolic Biochemistry
7.91J/20.490J Foundations of Computational and Systems Biology
8.591J/7.81J Systems Biology
10.542 Biochemical Engineering
10.544 Metabolic and Cell Engineering
10.546J/5.70J/20.465J Statistical Thermodynamics with Applications to Biological Systems
10.977 Advances in Bioinformatics and Metabolic Engineering
20.106J Systems Microbiology
20.440 Analysis of Biological Networks
20.450 Molecular and Cellular Pathophysiology
20.485 Tools for Assessing Biological Function
HST.508 Quantitative Genomics

 

Rotations and Thesis Research

During the first year, students will rotate through three labs of MIT faculty that participate in the Microbiology Graduate Program. These rotations will help provide students broad exposure to microbiology research and will be used to select a lab for their thesis research by the end of the first year. Given the interdisciplinary nature of the program and many research programs, students may be able to work jointly with more than one research supervisor.

Teaching Experience

Learning to effectively communicate scientific ideas is an important skill. Students in the Microbiology program will have an opportunity to improve their communication skills through teaching. Each student will serve as a teaching assistant for one term in an undergraduate or graduate subject related to microbiology. This will typically take place in the second year.

Training in the Ethical Conduct of Research

All students will participate in a course on the ethical conduct of research. This will typically take place during the first and third years.

Qualifying Exams

Students will proceed to PhD candidacy after successful completion of a qualifying exam, typically during the second year. Students will submit a written research proposal in the style of a grant or fellowship application based on their planned thesis project. Students will then present and discuss the research proposal with a small committee of faculty.

Student Advising

In the first year, students will be advised by members of the graduate committee. Once students join a thesis lab, the research mentor will be the primary advisor. Early in the second year, students will form a thesis committee and meet at least annually. The committee will consist of faculty with expertise in the student's area of research and collectively provide the breadth expected by the program. The thesis committee will primarily provide advice on research. In addition, in the student's early years the thesis committee will also provide advice on coursework to ensure that students have the appropriate breadth and depth for their educational program. In later years, the graduate and thesis committees will also provide students with advice on career options.

Financial Support and Fellowships

Students in the program will be financially supported throughout their training. This support includes tuition, stipend, and health insurance. All students in the program will receive a stipend that is sufficient to support living in the Cambridge/Boston area. The stipend will be approximately the same as for graduate students in other MIT departments.

During the first year, students are supported by the Microbiology program. In subsequent years, students will be supported as research assistants in their thesis lab.

Although students will be supported, they are strongly encouraged to apply for fellowships.

Inquiries

For further information about the Graduate Program in Microbiology, contact Bonnie Lee Whang, Room 68-139, microbiology@mit.edu, or visit http://microbiology.mit.edu/.

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