Hynes, R.O. (2008). US policies on human embryonic stem cells. Nature Reviews Molecular Cell Biology, Advance Online Publication, published online 9 October 2008; doi: 10.1038/nrm2528.
Stern, P., Astrof, S., Erkeland, S.J., Schustak, J., Sharp, P.A. and Hynes, R.O. (2008). A system for Cre-regulated RNA interference in vivo. Proc. Natl. Acad. Sci. USA 105:13895-13900.
Li, S., Jin, Z., Koirala, S., Bu, L., Xu, L., Hynes, R.O., Walsh, C.A., Corfas, G. and Piao, X. (2008). GPR56 regulates pial basement membrane integrity and cortical lamination, J. Neurosci. 28:5817-5826.
McCarty, J.H., Barry, M., Crowley, D., Bronson, R.T., Lacy-Hulbert, A. and Hynes, R.O. (2008). Genetic ablation of ±v integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma. Am. J. Path. 172:1740-1747.
Shinde, A.V., Bystroff, C., Wang, C., Vincent, P.A., Vogelezang, M.G., Hynes, R.O. and Van De Water, L. (2008). Identification of the Peptide Sequences within the EIIIA (EDA) Segment of Fibronectin That Mediate Integrin α9β1-dependent Cellular Activities. J. Biol. Chem. 283: 2858-2870.
Wong, S.Y., Crowley, D, Bronson, R.T. and Hynes, R.O. (2008). Analyses of the Role of Endogenous SPARC in mouse models of prostate and breast cancer. Clin. Exp. Metastasis 25: 109-118.
Xu, L., Shen, S., Hoshida, Y., Subramanian, A., Ross, K., Brunet, J.P., Ramaswamy, S., Mesirov, J.P. and Hynes, R.O. (2008). Gene expression changes in an animal melanoma model correlate with aggressiveness of human melanoma metastases. Mol Cancer Res. 6:760-769.
Izawa, A., Ueno, T., Jurewicz, M., Ito, T., Tanaka, K., Takahashi, M., Ikeda, U., Sobolev, O., Fiorina, P., Smith, R.N., Hynes, R.O. and Abdi, R. (2007). Importance of donor- and recipient-derived selectins in cardiac allograft rejection. J. Am. Soc. Nephrol. 18:2929-2936.
Wong, S.Y., Haack, H., Kissil, J.L., Barry, M., Bronson, R.T., Shen, S.S., Whittaker, C.A., Crowley, D, and Hynes, R.O. (2007). Protein 4.1B suppresses prostate cancer progression and metastasis. Proc. Natl. Acad. Sci. USA 104: 12784-12789.
Wong, S.Y. and Hynes, R.O. (2007). Tumor-lymphatic interactions in an activated stromal microenvironment. J. Cell Biochem. 101: 840-850.
Zou, Z., Chen, H., Schmaier, A.A., Hynes R.O. and Kahn, M.L. (2007). In vivo structure-function analysis reveals discrete b3 integrin inside-out and outside-in signaling pathways in platelets. Blood 109: 3284-3290.
Xu, L. and Hynes, R.O. (2007). GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment. Cell Cycle. 6:160-165.
Lacy-Hulbert, A., Ueno, T., Ito, T., Jurewicz, M., Izawa, A., Smith, R.N., Chase, C.M., Tanaka, K., Fiorina, P., Russell, P.S., Auchincloss, H., Sayegh, M.H., Hynes, R.O. and Abdi, R. (2007). b3 integrins regulate lymphocyte migration and cytokine responses in heart transplant rejection. Am. J. Transplant. 7: 1080-1090.
Eshghi, S., Vogelezang, M.G., Hynes, R.O., Griffith, L.G. and Lodish, H.F. (2007). a4b1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development. J. Cell Biol. 177: 871-880.
Hynes, R.O. (2007). Cell-matrix adhesion in vascular development. J. Thromb. Haemostasis. 5(Suppl.1) 32-40.
Astrof, S., Kirby, A., Lindblad-Toh, K., Daly, M.J. and Hynes, R.O. (2007). Heart development in fibronectin-null mice is governed by a genetic modifier on chromosome four. Mech. Dev. 124: 551-558.
Wong, S.Y., Haack, H., Kissil, J.L., Barry, M., Bronson, R.T., Shen, S.S., Whittaker, C.A., Crowley, D, and Hynes, R.O. (2007). Protein 4.1B suppresses prostate cancer progression and metastasis. Proc. Natl. Acad. Sci. USA 104: 12784-12789.
Astrof, S., Crowley, D. and Hynes, R.O. (2007). Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin. Devel. Biol. 311: 11-24.
Lacy-Hulbert, A., Smith, A.M., Tissire, H., Barry, M., Crowley, D., Bronson, R.T., Roes, J.T., Savill, J.S. and Hynes, R.O. (2007). Ulcerative colitis and impaired clearance of apoptotic cells induced by loss of myeloid av integrins. Proc. Natl. Acad. Sci. USA 104: 15823-15828.
Hynes R. (2007). Reply to 'UK set to reverse stance on research with chimeras'. Nat Med. 13:1133.
Ni, H., Chen, P., Spring, C.M., Semple, J.W., Lazarus, A.H., Hynes, R.O. and Freedman, J. (2006). A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy. Blood 107:2976-2983.
Matuskova, J., Chauhan, A.K., Cambien, B., Astrof, S., Dole, V.S., Piffath, C.L., Hynes, R.O. and Wagner, D.D. (2006). Decreased plasma fibronectin leads to delayed thrombus growth in injured arterioles. Arteriosclerosis, Thrombosis and Vasc. Biol. 26: 1391-1396.
Xu, L., Begum, S., Hearn, J.D. and Hynes, R. O. (2006). GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis. Proc. Natl. Acad. Sci. USA. 103: 9023-9028.
Yang, H., Reheman. A., Chen, P., Zhu, G., Hynes, R.O., Freedman, J., Wagner, D.D. and Ni, H. (2006). Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo. J. Thromb. Haemost. 4:2230-2237.
Sea Urchin Genome Sequencing Consortium, (2006). The genome of the sea urchin Strongylocentrotus purpuratus. Science 314:941-952.
Whittaker, C.A., Bergeron, K.F., Whittle, J., Brandhorst, B.P., Burke, R.D. and Hynes R. O. (2006). The echinoderm adhesome. Dev. Biol. 300: 252-266.
Reynolds, L., Conti, F.A., Lucas, M. Grose, R., Robinson, S., Stone, M., Saunders, G.,C. Dickson, C., Hynes, R.O., Lacy-Hulbert, A. and Hodivala-Dilke, K. (2005). Accelerated re-epithelialisation in b3-integrin-deficient mice is associated with enhanced TGFb-mediated signaling. Nat. Med. 11: 167-174.
Hamano, Y., Zeisberg, M., Sugimoto, H., Lively, J.C., Maeshima, Y., Yang, C., Hynes, R.O., Werb, Z., Sudhakar, A. and Kalluri, R. (2003). Physiological levels of tumstatin, a fragment of collagen IV a3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via aVb3 integrin Cancer Cell 3:589-601.
Hynes, R.O. (2004). The emergence of integrins: a personal and historical perspective. Matrix Biology 23: 331-338.
Hynes, R.O. (2003). Metastatic potential: generic predisposition of the primary tumor or rare, metastatic variants—or both? Cell 113: 821-823.
Hynes, R.O. (2002). Integrins: bi-directional, allosteric, signaling machines. Cell : 110:673-687.
Hynes, R.O. (2002). A reevaluation of integrins as regulators of angiogenesis. Nature Medicine 8: 918-921.
Reynolds, L., Wyder, L., Lively, J.C., Taverna, D., Robinson, S.D., Huang, X., Sheppard, D, Hart, I., Hynes, R.O. and Hodivala-Dilke, K. (2002). Enhanced pathological angiogenesis in mice lacking b3-integrin or b3- and b5-integrins. Nature Medicine 8: 27-34.
Clark, E.A., Golub, T.R., Lander, E. and Hynes, R.O. (2000) Genomic analysis of metastasis reveals an essential role for rhoC. . Nature, 406: 532-535.
Arroyo, A.G., Yang, J.T., Rayburn, H. and Hynes, R.O. (1999). a4 integrins regulate the proliferation/differentiation balance of multilineage hematopoietic progenitors in vivo. Immunity 11: 555-566.
Hynes, R.O. (1999). Cell adhesion: old and new questions. Trends Millenium Issue. M33-37.
Bader, B.L., Rayburn, H., Crowley, D. and Hynes, R.O. (1998) Extensive vasculogenesis, angiogenesis and organogenesis precede lethality in mice lacking all av integrins. Cell 95: 507-519.
Arroyo, A. G., Yang, J. T., Rayburn, H. and Hynes, R. O. (1996) Differential requirements for a4 integrins during fetal and adult hematopoiesis. Cell 85: 997-1008.
Rees, D.J.G. Ades, S.A., Singer, S.J. and Hynes, R.O. (1990). Sequence and domain organization of talin, a member of a family of submembranous cytoskeletal proteins. Nature 347: 685-689.
Ali, I.U. and Hynes, R.O. (1978). Role of disulfide bonds in the attachment and function of large, external, transformation-sensitive glycoprotein at the cell surface. Biochem. Biophys. Acta 510:140-150.