Angiogenesis Publications

1. Hynes, R.O. (2007).  Cell-matrix adhesion in vascular development.  J. Thromb. Haemostasis. 5(Suppl.1) 32-40.
2. McCarty, J.H. and Hynes, R.O. (2007).  Endothelial cell integrins. in Endothelial Biomedicine, Aird, W.C (Ed.).  Cambridge University Press, Cambridge and New York.
3. Wong, S.Y. and Hynes, R.O. (2007).  Tumor-lymphatic interactions in an activated stromal microenvironment.     J. Cell Biochem. 101(4):840-50.
4. Wong, S.Y. and Hynes, R.O. (2006). Lymphatic or hematogenous dissemination: how does a metastatic tumor cell decide?  Cell Cycle 5: 812-817.
5. McCarty, J.H. and Hynes, R.O. (2006) . Integrins and formation of the microvasculature  in  Encyclopedia of the Microvasculature. Shepro, D. (editor), Elsevier Academic Press.
6. Wong, S.Y., Haack, H., Crowley, D., Barry, M., Bronson, R.T. and Hynes. R.O. (2005). Tumor-secreted VEGF-C is necessary for prostate cancer lymphangiogenesis, but lymphangiogenesis is unnecessary for lymph node metastasis.  Cancer Res. 65: 9789-9798.
7. McCarty, J.H., Lacy-Hulbert, A., Charest, A., Bronson, R.T., Crowley, D., Housman, D.H., Savill, J. and Hynes, R.O.  (2005).  Selective ablation of av integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death.  Development 132:165-176.
8. Astrof, S., Crowley, D., George, E.L., Fukuda, T., Sekiguchi, K., Hanahan, D. and Hynes, R.O. (2004). Direct test of potential roles of EIIIA and EIIIB alternatively spliced variants of fibronectin in physiological and tumor angiogenesis. Mol. Cell Bio. 19: 8662-8670.
   
9. Hamano, Y., Zeisberg, M., Sugimoto, H., Lively, J.C., Maeshima, Y., Yang, C., Hynes, R.O., Werb, Z., Sudhakar, A. and Kalluri, R. (2003). Physiological levels of tumstatin, a fragment of collagen IV a3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via αVβ3 integrin. Cancer Cell 3: 589-601.
   
10. Hynes, R.O., Lively, J.C., McCarty, J.H., Taverna, D., Xiao, Q. and Hodivala-Dilke, K. (2002). Diverse roles of integrins and their ligands in angiogenesis. Cold Spring Harbor Symp. Quant. Biol. 67: 143-153.
    
11. Hynes, R.O. (2002) A reevaluation of integrins as regulators of angiogenesis. Nature Medicine 8: 918-921.
    
12. McCarty, J.H., Monahan-Earley, R.A., Dvorak, A.M., Brown, L.F., Keller, M., Gerhardt, H., Rubin, K., Shani, M., Wolburg, H., Bader, B.L., Dvorak, H.F. and Hynes, R.O. (2002). Defective associations between blood vessels and developing neuronal parenchyma lead to cerebral hemorrhage in mice lacking αv integrins. Mol. Cell. Biol. 22: 7667-7677.
    
13. Francis, S.E., Goh, K.L., Hodivala-Dilke, K., Bader, B.L., Stark, M., Davidson, D. and Hynes, R.O. (2002). Central roles of α5 β1 integrin and fibronectin in vascular development in mouse embryos and embryoid bodies. Arteriosclerosis, Thrombosis and Vasc. Biol. 22: 927-933.
    
14. Maeshima, Y., Sudhakar, A., Lively, J.C., Ueki, K., Kharbanda, S., Kahn, C.R., Sonenberg, N., Hynes, R.O. and Kalluri, R. (2002).αvΒ3-integrin-dependent endothelial cell-specific protein synthesis inhibitor from vascular basement membrane. Science 295: 140-143.
    
15. Reynolds, L., Wyder, L., Lively, J.C., Taverna, D., Robinson, S.D., Huang, X., Sheppard, D, Hart, I., Hynes, R.O. and Hodivala-Dilke, K. (2002). Enhanced pathological angiogenesis in mice lacking β3-integrin or β3- and β5-integrins. Nature Medicine 8: 27-34.
    
16. Rodriguez-Manzaneque, J.C., Lane, T.F., Ortega, M.A., Hynes, R.O., Lawler, J. and Iruela-Arispe, M.L. (2001). Thrombospondin-1 suppresses spontaneous tumor growth and angiogenesis and inhibits activation of matrix metalloprotease-9 and mobilisation of VEGF. Proc. Natl. Acad. Sci. USA 98: 12485-12490.
    
17. Taverna, D. and Hynes, R.O. (2001). Reduced blood vessel formation and tumor growth in α5 integrin-negative teratocarcinomas and embryoid bodies. Cancer Res. 61:5255-5261.
    
18. Hynes, R.O., Bader, B.L. and Hodivala-Dilke, K. (1999) Integrins in vascular development. Brazilian J. Medical and Biological Res..32:501-510.
    
19. Bader, B.L., Rayburn, H., Crowley, D. and Hynes, R.O. (1998) Extensive vasculogenesis, angiogenesis and organogenesis precede lethality in mice lacking all αv integrins. Cell 95: 507-519.
    
20. Hynes, R.O. and Bader, B.L. (1997) Targeted mutations in integrins and their ligands: their implications for vascular biology. Thromb. and Haem. 78:83-87.
    
21. George, E.L., Baldwin, H.S. and Hynes, R.O. (1997). Fibronectins are essential for heart and blood vessel morphogenesis, but are dispensible for initial specification of precursor cells. Blood 90: 3073-3086.
    
22. Yang, J.T., Rayburn, H. and Hynes, R.O. (1993) Embryonic mesodermal defects in α5-integrin-deficient mice. Development 119:1093-1105.
23. George, E.L., Georges-Labouesse, E.N., Patel-King, R.S., Rayburn, H. and Hynes, R.O. (1993) Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin. Development 119:1079-1091.