Cancer Publications

  1. Xu, L., Shen, S., Hoshida, Y., Subramanian, A., Ross, K., Brunet, J.P., Ramaswamy, S., Mesirov, J.P. and Hynes, R.O.  (2008).  Gene expression changes in an animal melanoma model correlate with aggressiveness of human melanoma metastases. Mol Cancer Res. 6:760-769.
  2. Wong, S.Y., Crowley, D, Bronson, R.T. and Hynes, R.O. (2008).  Analyses of the Role of Endogenous SPARC in mouse models of prostate and breast cancer.  Clin. Exp. Metastasis 25: 109-118.
  3. McCarty, J.H., Barry, M., Crowley, D., Bronson, R.T., Lacy-Hulbert, A. and Hynes, R.O. (2008).  Genetic ablation of av integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma.  Am. J. Path. 172:1740-1747.
  4. Wong, S.Y. and Hynes, R.O. (2007).  Tumor-lymphatic interactions in an activated stromal microenvironment.     J. Cell Biochem. 101: 840-850.
  5. Xu, L. and Hynes, R.O. (2007). GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment. Cell Cycle. 6:160-165.
  6. Wong, S.Y., Haack, H., Kissil, J.L., Barry, M., Bronson, R.T., Shen, S.S., Whittaker, C.A., Crowley, D, and Hynes, R.O. (2007).  Protein 4.1B suppresses prostate cancer progression and metastasis.  Proc. Natl. Acad. Sci. USA 104: 12784-12789.
  7. Wong, S.Y., Crowley, D, Bronson, R.T. and Hynes, R.O. (2007).  Analyses of the Role of Endogenous SPARC in mouse models of prostate and breast cancer.  Clinical & Experimental Metastasis (Ms in press).
  8. Xu, L. and Hynes, R.O. (2006). GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment. Cell Cycle. 6(2):160-5.
  9. Xu, L., Begum, S., Hearn, J.D. and Hynes, R. O.  (2006).  GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis. Proc. Natl. Acad. Sci. USA. 103: 9023-9028.
  10. Wong, S.Y. and Hynes, R.O. (2006). Lymphatic or hematogenous dissemination: how does a metastatic tumor cell decide?  Cell Cycle 5: 812-817.
  11. Taverna, D., Crowley, D., Connolly, M., Bronson, R.T. and Hynes, R.O.  (2005). A direct test of potential roles for b3 and b5 integrins in growth and metastasis of murine mammary carcinomas.  Cancer Res. 65: 10324-10329.
  12. Wong, S.Y., Haack, H., Crowley, D., Barry, M., Bronson, R.T. and Hynes. R.O. (2005). Tumor-secreted VEGF-C is necessary for prostate cancer lymphangiogenesis, but lymphangiogenesis is unnecessary for lymph node metastasis.  Cancer Res. 65: 9789-9798.
  13. Astrof, S., Crowley, D., George, E.L., Fukuda, T., Sekiguchi, K., Hanahan, D. and Hynes, R.O. (2004).  Direct test of potential roles of EIIIA and EIIIB alternatively spliced segments of fibronectin in physiological and tumor angiogenesis.  Mol. Cell. Biol. 24: 8662-8670.
  14. Taverna, D., Moher, H., Crowley, D., Borsig.L., Varki, A. and Hynes, R.O. (2004). Increased primary tumor growth in mice null for β3- or β3/β5-integrins or selectins. Proc. Natl. Acad. Sci. USA 101: 763-768.
  15. Hynes, R.O. (2003). Metastatic potential: generic predisposition of the primary tumor or rare, highly metastatic variants—or both? Cell 113: 1-3.
  16. Borsig, L., Wong, R., Hynes, R.O., Varki, N.M. and Varki, A. (2002). Synergistic effect of L- and P-selectin in facilitating tumor metastasis in a syngeneic system involving non-mucin ligands - further evidence for selectin inhibition as a mode of heparin action. Proc. Natl. Acad. Sci. USA 99: 2193-2198.
  17. Reynolds, L., Wyder, L., Lively, J.C., Taverna, D., Robinson, S.D., Huang, X., Sheppard, D, Hart, I., Hynes, R.O. and Hodivala-Dilke, K. (2002). Enhanced pathological angiogenesis in mice lacking β3-integrin or β3- and β5-integrins. Nature Medicine 8: 27-34.
  18. Taverna, D. and Hynes, R.O. (2001). Reduced blood vessel formation and tumor growth in α5 integrin-negative teratocarcinomas and embryoid bodies. Cancer Res. 61:5255-5261.
  19. Lawler, J., Miao, W.M., Duquette, M., Bouck, N., Bronson, R.T. and Hynes, R.O. (2001). Thrombospondin-1 gene expression affects survival and tumor spectrum of p53-deficient mice. Am.J. Path. 159: 1949-1956
  20. Rodriguez-Manzaneque, J.C., Lane, T.F., Ortega, M.A., Hynes, R.O., Lawler, J. and Iruela-Arispe, M.L. (2001). Thrombospondin-1 suppresses spontaneous tumor growth and angiogenesis and inhibits activation of matrix metalloprotease-9 and mobilisation of VEGF. Proc. Natl. Acad. Sci. USA 98: 12485-12490.
  21. Clark, E.A., Golub, T.R., Lander, E. and Hynes, R.O. (2000) Genomic analysis of metastasis reveals an essential role for rhoC. Nature, 406: 532-535.
  22. Taverna, D., Ullman-Culleré, M., Rayburn, H., Bronson, R.T. and Hynes, R.O. (1998). A test of the role of α5 integrin/fibronectin interactions in tumorigenesis. Cancer Res., 58: 848-853.
  23. Stellmach, V., Volpert, O.V., Crawford, S.E., Lawler, J., Hynes, R.O. and Bouck, N. (1997) Tumor suppressor genes and angiogenesis: the role of p53 in fibroblasts. Eur. J. Cancer 32A: 2394-2400.
  24. Hynes, R.O., and Plantefaber, L.C. (1991). Integrin receptors for extracellular matrix and their involvement in oncogenic transformation. In Origins of Human Cancer: A Comprehensive Review (Brugge, J., Curran, T., Harlow, E and McCormick, F.). Plainview, NY: Cold Spring Harbor. pp. 293-307.
  25. Plantefaber, L.C. and Hynes, R.O. (1989). Changes in integrin receptors on oncogenically transformed cells. Cell 56:281-290.
  26. Wagner, D.D., Ivatt, R., Destree, A.T. and Hynes, R.O. (1981). Similarities and differences between the fibronectins of normal and transformed hamster cells. J. Biol. Chem. 256:11708-11715.
  27. Senger D.R., Wirth, D.F., Bryant, C. and Hynes, R.O. (1980). Transformation-specific secreted proteins in "Viral Oncogenes", Cold Spring Harbor Symposia 44:651-657.
  28. Senger, D.R., Wirth, D.F. and Hynes, R.O. (l980). Transformation-specific secreted phosphoproteins. Nature 286:619-621.
  29. Senger, D.R., Wirth, D.F. and Hynes, R.O. (1979). Transformed mammalian cells secrete specific proteins and phosphoproteins. Cell 16:885-894.
  30. Mautner, V.M. and Hynes, R.O. (1977). Surface distribution of LETS protein in relation to the cytoskeleton of normal and transformed fibroblasts. J. Cell Biol. 75:743-768.
  31. Ali, I.U., Mautner, V.M., Lanza, R.P. and Hynes, R.O. (1977). Restoration of normal morphology, adhesion and cytoskeleton in transformed cells by addition of a transformation-sensitive surface protein. Cell 11:115-126.
  32. Critchley, D.R., Wyke, J.A. and Hynes, R.O. (1976). Cell surface and metabolic labelling of the proteins of normal and transformed chicken cells. Biochim. Biophys. Acta 436:335-352.
  33. Hynes, R.O. (1976). Cell surface proteins and malignant transformation. Biochim. Biophys. Acta 458:73-107.
  34. Hynes, R.O. and Wyke, J.A. (1975). Alterations in surface proteins in chicken cells transformed by temperature-sensitive mutants of Rous sarcoma virus. Virology 64:492-504.
  35. Hynes, R.O. (1974). Role of surface alterations in cell transformation: the importance of proteases and surface proteins. Cell 1:147-158.
  36. Hynes, R.O. (1973). Alteration of cell-surface proteins by viral transformation and by proteolysis. Proc. Natl. Acad. Sci. USA 70:3170-3174.