Recent Publications

  1. Hynes, R.O. (2008). US policies on human embryonic stem cells. Nature Reviews Molecular Cell Biology 9: 993-997.
  2. Stern, P., Astrof, S., Erkeland, S.J., Schustak, J., Sharp, P.A. and Hynes, R.O. (2008). A system for Cre-regulated RNA interference in vivo. Proc. Natl. Acad. Sci. USA 105:13895-13900.
  3. Shinde, A.V., Bystroff, C., Wang, C., Vincent, P.A., Vogelezang, M.G., Hynes, R.O. and Van De Water, L. (2008). EIIIA (ED-A), the alternatively spliced segment of fibronectin, exhibits cryptic cell adhesive activity to integrin α9β1. J. Biol. Chem. 283: 2858-2870.
  4. Xu, L., Shen, S., Hoshida, Y., Subramanian, A., Ross, K., Brunet, J.P., Ramaswamy, S., Mesirov, J.P. and Hynes, R.O. (2008). Gene expression changes in an animal melanoma model correlate with aggressiveness of human melanoma metastases. Mol Cancer Res. 6:760-769.
  5. Li, S., Jin, Z., Koirala, S., Bu, L., Xu, L., Hynes, R.O., Walsh, C.A., Corfas, G. and Piao, X. (2008) GPR56 regulates pial basement membrane integrity and cortical lamination, J. Neurosci. 28:5817-5826.
  6. McCarty, J.H., Barry, M., Crowley, D., Bronson, R.T., Lacy-Hulbert, A. and Hynes, R.O. (2008). Genetic ablation of av integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma. Am. J. Path. 172:1740-1747.
  7. Wong, S.Y., Crowley, D, Bronson, R.T. and Hynes, R.O. (2008). Analyses of the Role of Endogenous SPARC in mouse models of prostate and breast cancer. Clin. Exp. Metastasis 25: 109-118.
  8. Astrof, S., Crowley, D. and Hynes, R.O. (2007). Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin. Devel. Biol. 311: 11-24.
  9. Hynes, R.O. (2007). Cell-matrix adhesion in vascular development. J. Thromb. Haemostasis. 5(Suppl.1) 32-40.
  10. Wong, S.Y., Haack, H., Kissil, J.L., Barry, M., Bronson, R.T., Shen, S.S., Whittaker, C.A., Crowley, D, and Hynes, R.O. (2007). Protein 4.1B suppresses prostate cancer progression and metastasis. Proc. Natl. Acad. Sci. USA 104: 12784-12789.
  11. Astrof, S., Kirby, A., Lindblad-Toh, K, Daly, M. and Hynes, R.O. (2007). Heart development in fibronectin-null mice is governed by a genetic modifier on chromosome four. Mech. Devel. 124:551-8.
  12. Eshghi, S., Vogelezang, M.G., Hynes, R.O., Griffith, L.G. and Lodish, H.F. (2007). a4b1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development. J. Cell Biol. 177: 871-880.
  13. Izawa, A., Ueno, T., Jurewicz, M., Ito, T., Tanaka, K., Takahashi, M., Ikeda, U., Sobolev, O., Fiorina, P., Smith, R.N., Hynes, R.O. and Abdi, R. (2007). Importance of donor- and recipient-derived selectins in cardiac allograft rejection. J. Am. Soc. Nephrol. 18:2929-2936
  14. Xu, L. and Hynes, R.O. (2007). GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment. Cell Cycle. 6(2):160-5
  15. Whittaker, C.A., Bergeron, K.F., Whittle, J., Brandhorst, B.P., Burke, R.D. and Hynes R. O. (2006). The echinoderm adhesome. Dev. Biol. 300: 252-266.
  16. Wong, S.Y. and Hynes, R.O. (2007). Tumor-lymphatic interactions in an activated stromal microenvironment. J. Cell Biochem. 101:840-50.
  17. Zou, Z., Chen, H., Schmaier, A.A., Hynes R.O. and Kahn, M.L. (2007). In vivo structure-function analysis reveals discrete b3 integrin inside-out and outside-in signaling pathways in platelets. Blood. 109:3284-90.
  18. Sea Urchin Genome Sequencing Consortium, (2006). The genome of the sea urchin Strongylocentrotus purpuratus. Science 314:941-952.
  19. Yang, H., Reheman. A., Chen, P., Zhu, G., Hynes, R.O., Freedman, J., Wagner, D.D. and Ni, H. (2006). Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo. J. Thromb. Haemost. 4:2230-2237.
  20. Xu, L., Begum, S., Hearn, J.D. and Hynes, R. O. (2006). GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis. Proc. Natl. Acad. Sci. USA. 103: 9023-9028.
  21. Wong, S.Y. and Hynes, R.O. (2006). Lymphatic or hematogenous dissemination: how does a metastatic tumor cell decide? Cell Cycle 5: 812-817.
  22. Matuskova, J., Chauhan, A.K., Cambien, B., Astrof, S., Dole, V.S., Piffath, C.L., Hynes, R.O. and Wagner, D.D. (2006). Decreased plasma fibronectin leads to delayed thrombus growth in injured arterioles. Arteriosclerosis, Thrombosis and Vasc. Biol. 26: 1391-1396.
  23. McCarty, J.H. and Hynes, R.O. (2007). Endothelial cell integrins. in Endothelial Biomedicine, Aird, W.C (Ed.). Cambridge University Press, Cambridge and New York.
  24. Ni, H., Chen, P., Spring, C.M., Semple, J.W., Lazarus, A.H., Hynes, R.O. and Freedman, J. (2006). A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy. Blood 107:2976-2983.