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ChemE Spring Seminar Series

Crystal Engineering for Morphology Evolution and Product Design

Michael Doherty
Department of Chemical Engineering, University of California, Santa Barbara

Friday, April 11, 2008
Room 66-110
3:00 PM (refreshments will be served at 2:45 pm)

All are welcome!    

Crystalline organic solids are ubiquitous as either final products or as intermediates in the specialty chemical, pharmaceutical, and home & personal care industries.  Virtually all small molecular weight drugs are isolated as crystalline materials, and over 90% of all pharmaceutical products are formulated in particulate, generally crystalline form.  Crystalline chemical intermediates, such as adipic acid, are produced in large amounts to make polymers and specialty products.  Skin creams and other personal care product formulations contain crystalline solids.  In most cases the properties of the crystalline solid have a major impact on the functionality of the product as well as the design and operation of the manufacturing process, and in most cases the two cannot considered separately.

In this lecture we will focus on new developments for predicting polymorph selection at the nucleation stage, and on predicting shape evolution of the resulting crystals, with particular emphasis on product and process engineering applications to pharmaceutical products.