Patrick S. Doyle
Current Research

Our research focuses on understanding the dynamics of single polymers and biomolecules under forces and fields. We utilize both experimental and computational approaches in our research in order to understand fundamental issues in a wide variety of applications ranging from lab-on-chip separations to polymer rheology. We profit from interdisciplinary collaboration with biologists, physicists and mechanical engineers.

The ability to visualize and manipulate single DNA molecules can provide unique and valuable insights. In our lab we directly observe single DNA molecules using fluorescence microscopy and manipulate them in custom built microdevices. In our DNA experiments we are focusing on designing new separation techniques for lab-on-chip devices, understanding polymer dynamics in complex flows and confined geometries, and studying single molecule biophysics.

To complement and often guide our experimental studies we perform large-scale Brownian Dynamics simulations. We are currently exploring rational design strategies to optimize DNA sequencing techniques and separations in microlithography arrays. Additionally, we are developing mutli-scale approaches to investigate polymer dynamics near and attached to interfaces for applications in microfluidics and adhesives

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