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Chemical approaches to the study of cell signaling

 Welcome to our lab, located on the 4th floor of Building 18 in the Chemistry Department at MIT. Our research is centered on the development and application of technologies for uncovering molecular signaling events in living cells. In the past, we have developed methods for labeling specific proteins in living cells with chemical probes, imaged protein-protein interactions, imaged the activity of specific enzymes, and developed small and monovalent quantum dots for single protein imaging in live cells. Current work expands and extends these reporter classes using in vitro evolution methods and computational design. Furthermore, we are applying our enzyme engineering and organic synthesis capabilities to develop new methods for the proteomic analysis of living cells. To learn more...

Alice Y. Ting
Ellen Swallow Richards Associate Professor
Department of Chemistry
Massachusetts Institute of Technology
Other affiliations: Broad Institute, Koch Institute, MIT Biophysics, Picower Institute

Philipp receives Simons (SCSB) postdoctoral fellowship (4-12-2013)

New postdoc Philipp Stawski joins the lab (4-1-2013)

Kurt receives NSF graduate research fellowship (3-29-2013)

Hyun-Woo and Peng's APEX proteomics paper highlighted in Nature Methods (3-28-2013)

Our lab receives a HFSP research grant, with Hayashi, Poncer, and de la Prida labs (3-19-2013)

Kayvon receives Simons Center for the Social Brain UROP funding (3-5-2013)

Monica is selected for the Amgen-UROP Scholars Program (3-1-2013)

Dan and Ken's paper "Imaging trans-cellular neurexin-neuroligin interactions by enzymatic probe ligation" appears in PLoS One (2-14-2013)

Hyun-Woo and Peng's paper "Proteomic mapping of mitochondria in living cells via spatially-restricted enzymatic tagging" appears in Science (1-31-2013). MIT news article.

Jeff's APEX EM paper highlighted in Nature Methods and Nature (12-13-2012)

Dan's paper "Quantum dot targeting with lipoic acid ligase and HaloTag for single molecule imaging on living cells" appears in ACS Nano (11-26-2012)

New graduate student Chai Kaewsapsak joins the lab (11-14-2012)

Jeff's paper "Engineered ascorbate peroxidase as a genetically encoded reporter for electron microscopy" appears in Nature Biotechnology (10-21-2012). MIT news article.

Our lab receives HHMI Collaborative Innovation Award, with Perrimon, Sanes, & Carr labs (9-7-2012)

Tao's Click paper highlighted in Nature Chemical Biology (6-18-2012)

Tao's paper "Fast, cell-compatible click chemistry with copper-chelating azides for biomolecular labeling" appears in Angewandte Chemie (5-3-2012)

Anupong wins 2012 Randolph G. Wei UROP award (4-30-2012)

Alice receives Vilcek Prize for Creative Promise in Biomedical Science (2-13-2012)

Jen's paper "Fluorophore targeting to cellular proteins via enzyme-mediated azide ligation and strain-promoted cycloaddition" appears in JACS (1-4-2012)