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Chemical approaches to the study of cell signaling

Welcome to our lab, located on the 4th floor of Building 18 in the Chemistry Department at MIT. Our research is centered on the development and application of technologies for uncovering molecular signaling events in living cells. In the past, we have developed methods for labeling specific proteins in living cells with chemical probes, imaged protein-protein interactions, imaged the activity of specific enzymes, and developed small and monovalent quantum dots for single protein imaging in live cells. Current work expands and extends these reporter classes using in vitro evolution methods and computational design. Furthermore, we are applying our enzyme engineering and organic synthesis capabilities to develop new methods for the proteomic analysis of living cells. To learn more...

Alice Y. Ting
Ellen Swallow Richards Associate Professor
Department of Chemistry
Massachusetts Institute of Technology
Other affiliations:
Broad Institute, Koch Institute, MIT Biophysics, Picower Institute
   
Tao's paper "Fast, cell-compatible click chemistry with copper-chelating azides for biomolecular labeling" appears in Angewandte Chemie (5-3-2012)
Anupong wins 2012 Randolph G. Wei UROP award (4-30-2012)
Ting receives Vilcek Prize for Creative Promise in Biomedical Science (2-13-2012)
Jen's paper "Fluorophore targeting to cellular proteins via enzyme-mediated azide ligation and strain-promoted cycloaddition" appears in JACS (1-4-2012)
Dan's paper "Diels-Alder cycloaddition for fluorophore targeting to specific proteins inside living cells" appears in JACS (12-16-2011)