The Fu Research Group
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New Chiral Ligands for Transition Metal-Catalyzed Reactions

We have established that "planar-chiral" heterocycles can function as useful ligands in a wide array of transition metal-catalyzed reactions. These levels of stereoselectivity represent the state-of-the-art for these processes.

• asymmetric coupling of alkynes with nitrones

scheme

 

• enantioselective hydrosilylation of ketones

scheme

 

• asymmetric isomerization of allylic alcohols

scheme

 


Selected Publications

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Catalytic Enantioselective O-H Insertion Reactions

   

J. Am Chem. Soc. 2005, 128, 4594-4595.

   

Maier, T. C.; Fu, G. C.

     
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Kinetic Resolutions of Azomethine Imines via Copper-Catalyzed [3+2] Cycloadditions

   

J. Am Chem. Soc. 2005, 127, 11244-11245.

   

Suárez, A.; Downey, C. W.; Fu, G. C.

     
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A New Copper-Catalyzed [3 + 2] Cycloaddition: Enantioselective Coupling of Terminal Alkynes with Azomethine Imines to Generate Five-Membered Nitrogen Heterocycles

   

J. Am Chem. Soc. 2003, 125, 10778-10779.

   

Shintani, R.; Fu, G. C.

     
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Catalytic Enantioselective Synthesis of ß-Lactams: Intramolecular Kinugasa Reactions and Interception of an Intermediate in the Reaction Cascade

   

Angew. Chem. Int. Ed. 2003, 42, 4082-4085.

   

Shintani, R.; Fu, G. C.

     
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Application of a New Family of P,N-Ligands to the Highly Enantioselective Hydrosilylation of Aryl Alkyl and Dialkyl Ketones

   

Angew. Chem. Int. Ed. 2002, 41, 3892-3894.

   

Tao, B.; Fu, G. C.

     
 
 

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Project Pages: Nucleophilic CatalysisChiral LigandsPalladium and Nickel CatalysisBoron Heterocycles

Other Pages: HomeAbout Greg FuGroup MembersPhotos

 


Professor Gregory C. Fu
Department of ChemistryMassachusetts Institute of Technology
77 Massachusetts Avenue, Room 18-290
Cambridge, MA 02139-4307 USA

(617) 253-2664 • fax: (617) 324-3611

email: gcf@mit.edu


 

This site was last updated on January 23, 2008

 

 
 

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