The Fu Research Group
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New Chiral Ligands for Transition Metal-Catalyzed Reactions

We have established that "planar-chiral" heterocycles can function as useful ligands in a wide array of transition metal-catalyzed reactions. These levels of stereoselectivity represent the state-of-the-art for these processes.

• asymmetric coupling of alkynes with nitrones



• enantioselective hydrosilylation of ketones



• asymmetric isomerization of allylic alcohols



Selected Publications

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Catalytic Enantioselective O-H Insertion Reactions


J. Am Chem. Soc. 2005, 128, 4594-4595.


Maier, T. C.; Fu, G. C.


Kinetic Resolutions of Azomethine Imines via Copper-Catalyzed [3+2] Cycloadditions


J. Am Chem. Soc. 2005, 127, 11244-11245.


Suárez, A.; Downey, C. W.; Fu, G. C.


A New Copper-Catalyzed [3 + 2] Cycloaddition: Enantioselective Coupling of Terminal Alkynes with Azomethine Imines to Generate Five-Membered Nitrogen Heterocycles


J. Am Chem. Soc. 2003, 125, 10778-10779.


Shintani, R.; Fu, G. C.


Catalytic Enantioselective Synthesis of ß-Lactams: Intramolecular Kinugasa Reactions and Interception of an Intermediate in the Reaction Cascade


Angew. Chem. Int. Ed. 2003, 42, 4082-4085.


Shintani, R.; Fu, G. C.


Application of a New Family of P,N-Ligands to the Highly Enantioselective Hydrosilylation of Aryl Alkyl and Dialkyl Ketones


Angew. Chem. Int. Ed. 2002, 41, 3892-3894.


Tao, B.; Fu, G. C.




Download PDFs: Curriculum VitaePublications by DatePublications by Project

Project Pages: Nucleophilic CatalysisChiral LigandsPalladium and Nickel CatalysisBoron Heterocycles

Other Pages: HomeAbout Greg FuGroup MembersPhotos


Professor Gregory C. Fu
Department of ChemistryMassachusetts Institute of Technology
77 Massachusetts Avenue, Room 18-290
Cambridge, MA 02139-4307 USA

(617) 253-2664 • fax: (617) 324-3611



This site was last updated on January 23, 2008



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