Fu Group Project - Palladium and Nickel Catalysis

Palladium- and Nickel-Catalyzed Coupling Reactions

Palladium- and nickel-catalyzed cross-couplings and Heck reactions are widely used in synthetic organic chemistry (e.g., in the total synthesis of taxol, rapamycin, and dynemicin). We have developed catalysts that can achieve couplings that were not previously possible. In addition, we have pursued mechanistic studies that have provided insight into the reaction pathways.

• Suzuki, Stille, and Negishi cross-coupling of aryl chlorides

• Heck reaction of aryl chlorides

• Suzuki reactions of alkyl bromides, tosylates, and chlorides

Selected Publications

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		Aminoalcohols as Ligands for Nickel-Catalyzed Suzuki Reactions of Unactivated Alkyl Halides, Including Secondary Alkyl Chlorides, with Arylboronic Acids
		J. Am. Chem. Soc. 2006, 128, 5360-5361.
		González-Bobes, F.; Fu, G. C.

		Catalytic Enantioselective Negishi Reactions of Racemic Secondary Benzylic Halides
		J. Am. Chem. Soc. 2005, 127, 10482-10483.
		Arp, F. O.; Fu, G. C.

		Asymmetric Nickel-Catalyzed Negishi Cross-Couplings of Secondary α-Bromo Amides with Organozinc Reagents
		J. Am. Chem. Soc. 2005, 127, 4595-4595.
		Fischer, C.; Fu, G. C.

		Elucidating Reactivity Differences in Palladium-Catalyzed Coupling Processes: The Chemistry of Palladium Hydrides
		J. Am. Chem. Soc. 2004, 126, 13178-13179.
		Hills, I. D.; Fu, G. C.

		Cross-Couplings of Unactivated Secondary Alkyl Halides: Room-Temperature Nickel-Catalyzed Negishi Reactions of Alkyl Bromides and Iodides
		J. Am. Chem. Soc. 2003, 125, 14726-14727.
		Zhou, J.; Fu, G. C.

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Project Pages: Nucleophilic Catalysis • Chiral Ligands • Palladium and Nickel Catalysis • Boron Heterocycles

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Professor Gregory C. Fu
Department of Chemistry • Massachusetts Institute of Technology
77 Massachusetts Avenue, Room 18-290
Cambridge, MA 02139-4307 USA

(617) 253-2664 • fax: (617) 324-3611

email: gcf@mit.edu

This site was last updated on January 23, 2008