The Jamison Research Group

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Bo Shen

Education:
  Massachusetts Institute of Technology, 2010 - present
Postdoctoral Associate with Professor Timothy F. Jamison
Ph.D. Vanderbilt University, Nashville, TN, 2010
with Prof. Jeffrey N. Johnston
B.Sc. University of Science and Technology of China (USTC), Hefei, Anhui, China, 2003
with Prof. Qing-Xiang Guo

Current Research:
    MIT-Novartis collaboration

Publications:
  • Shen, B.; Jamison, T. F. “Continuous Flow Photochemistry for the Rapid and Selective Synthesis of 2’-Deoxy and 2’,3’-Dideoxynucleosides” Aust. J. Chem. 2013, 66, 157-164. (invited contribution for the special issue on Continuous Flow Processing)
  • Leighty, M. W.; Shen, B.; Johnston J. N. “Enantioselective Synthesis of α-Oxy Amides via Umpolung Amide Synthesis” J. Am. Chem. Soc. 2012, 134, 15233.
  • Shen, B.; Jamison, T. F. "Rapid Continuous Synthesis of 5′-Deoxyribonucleosides in Flow via Brønsted Acid Catalyzed Glycosylation" Org. Lett. 2012, 14, 3348.
  • Shen, B., Bedore, M. W.; Sniady, A.; Jamison, T. F. "Continuous Flow Photocatalysis Enhanced Using an Aluminum Mirror: Rapid and Selective Synthesis of 2’-Deoxy and 2’,3’-Dideoxynucleosides" Chem. Commun. 2012, 48, 7444.
  • Shackleford, J. P.*; Shen, B.*; Johnston J. N. "Discovery of Competing Anaerobic and Aerobic Pathways in Umpolung Amide Synthesis Allows for Site-selective Amide 18O-Labeling" Proc. Natl. Acad. Sci. USA 2012, 109, 44. (*equal contribution)
  • Nagy, K. D.; Shen, B.; Jamison, T. F.: Jensen, K. F. "Mixing and Dispersion in Small-Scale Flow Systems" Org. Process Res. Dev. 2012, 16, 976-981.
  • Shen, B.; Makley, D. M.; Johnston J. N. "Umpolung Reactivity in Amide and Peptide Synthesis" Nature 2010, 465, 1027.
  • Shen, B.; Johnston J. N. "A Formal Enantioselective Acetate Mannich Reaction: The Nitro Functional Group as a Traceless Agent for Activation and Enantiocontrol in the Synthesis of β-Amino Acids” Org. Lett. 2008, 10, 4397-4400.
  • Singh, A.; Yoder, R. A.; Shen, B.; Johnston J. N. “Chiral Proton Catalysis: Enantioselective Brønsted Acid Catalyzed Additions of Nitroacetic Acid Derivatives as Glycine Equivalents” J. Am. Chem. Soc. 2007, 129, 3466-3467.
  • Tan, X.-H.; Hou, Y.-Q.; Shen, B.; Liu, L.; Guo, Q.-X. "SnCl2/PdCl2-Mediated Aldehyde Allylation in Fully Aqueous Media” Tet. Lett. 2004, 45, 5525-5528.
  • Tan, X.-H.; Shen, B.; Deng, W.; Zhao, H.; Liu, L.; Guo, Q.-X. "Novel Carbonyl Allylation Mediated by SnCl2/TiCl3 in Water” Org. Lett.2003, 5, 1833-1835.
  • Tan, X.-H.; Shen, B.; Liu, L.; Guo, Q.-X. "Novel Carbonyl Allylation Mediated by SnCl2/Cu in Water” Tet. Lett.2002, 43, 9373-9376.

Contact:
    bshen at mit dot edu