The Jamison Research Group

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James Mousseau

Education:
  Massachusetts Institute of Technology, 2011 - present
Postdoctoral Fellow with Professor Timothy F. Jamison
Ph.D. Université de Montréal, Montréal, Qc, 2011
"Direct Functionalization of heterocyclic and non-heterocyclic arenes"
with Prof. André B. Charette
M.Sc. Concordia University, Montréal, Qc, 2007
"Synthesis of Crescent Shaped Heterocyclic Urea-Linked Foldamers"
with Prof. Louis A. Cuccia
B.Sc. Concordia University, Montréal, Qc, 2004
with Prof. Heidi M. Muchall

Current Research:
    Development of novel methods in cascade epoxide ring-opening processes

Publications:
  • Mousseau, J. J.; Charette, A. B. "Direct Functionalization Processes: A Journey from Palladium-, to Copper-, to Iron-, to Nickel-, to Metal-Free Coupling Reactions" Acc. Chem. Res. In Press.
  • Pelletier, G.; Lie, S.; Mousseau, J. J.; Charette, A. B. "One-pot Synthesis of 1-Iodoalkynes and Trisubstituted Alkenes" Org. Lett. 2012, 14, 5464-5467
  • Bull, J. A.; Mousseau, J. J.; Pelletier, G.; Charette, A. B. Synthesis of Pyridine and Dihydropyridine Derivatives by Regio- and Stereoselective Addition to N-Activated Pyridines. Chem. Rev. 2012, 112, 2642-2713.
  • Mousseau, J. J.; Bull, J. A.; Ladd, C. L.; Fortier, A.; Sustac Roman, D.; Charette, A. B. "Synthesis of 2- and 2,3-Substituted Pyrazolo[1,5-a]pyridines: Scope and Mechanistic Considerations of a Domino Direct Alkynylation and Cyclization of N-Iminopyridinium Ylides Using Alkenyl Bromides, Alkenyl Iodides, and Alkynes." J. Org. Chem. 2011, 76, 8243–8261
  • Mousseau J. J.  “ 4-Methylbenzenesulfonamide ” e-EROS, Encyclopedia of Reagents for Organic Synthesis. Wiley, 2011.
  • Mousseau J. J.  “β-Chloroethyl chloroformate” e-EROS, Encyclopedia of Reagents for Organic Synthesis. Wiley, 2011.
  • Mousseau J. J.  “3,5-Bis(methoxycarbonyl)-1-(phenylmethyl)pyridinium bromide” e-EROS, Encyclopedia of Reagents for Organic Synthesis. Wiley, 2011.
  • Mousseau, J. J.; Vallée, F.; Lorion, M. M.; Charette, A. B. Umpolung Direct Arylation Reactions: Facile Process Requiring only Catalytic Palladium and Sub-Stoichiometric Amount of Silver Salts. J. Am. Chem. Soc. 2010, 132, 14412-14414.

  • Bull, J. A.; Mousseau, J. J.; Charette, A. B. Convenient One-Pot Synthesis of (E)-ß-Aryl Vinyl Halides from Benzyl Bromides and Dihalomethanes. Org. Synth. 2010, 87, 170-177.

  • Vallée, F.; Mousseau, J. J.; Charette, A. B. Iron-Catalyzed Direct Arylation Through an Aryl Radical Transfer Pathway. J. Am. Chem. Soc. 2010, 132, 1514-1516.
  • Mousseau, J. J.; Bull, J. A.; Charette, A. B. Ligand-Free Copper-Catalyzed Direct Alkenylation of N-Iminopyridinium Ylides. Angew. Chem., Int. Ed. 2010, 49, 1115-1118.

  • Mousseau, J. J.; Fortier, A.; Charette, A. B. Synthesis of 2-Substituted Pyrazolo[1,5-a]pyridines Through Cascade Direct Alkenylation/Cyclization Reactions. Org. Lett. 2010, 12, 516-519.

  • Mousseau, J. J.; Xing, L.; Tang, N.; Cuccia, L. A. Design and Synthesis of Urea-Linked Heterocycles - A Route Towards Convoluted Foldamers. Chem. Eur. J. 2009, 15, 10030-10038.
  • Bull, J. A.; Mousseau, J. J.; Charette A. B. Convenient One-Pot Synthesis of (E)-ß-Aryl Vinyl Halides from Benzyl Bromides and Dihalomethanes. Org. Lett. 2008, 10, 5485-5488.
  • Mousseau, J. J. Larivée, A.; Charette, A. B. Palladium-Catalyzed Benzylic C-H Insertion of 2-Substituted N-Iminopyridinium Ylides. Org. Lett. 2008, 10, 1641-1643.

  • Larivée, A., Mousseau J. J., Charette, A. B. Palladium-Catalyzed Direct C-H Arylation of N-Iminopyridinium Ylides: Application to the Synthesis of (±)-Anabasine. J. Am. Chem. Soc. 2008, 130, 52-54.

Contact:
    jj_mouss at mit dot edu