The Jamison Research Group


Matthew Katcher

  Massachusetts Institute of Technology, 2013 - present
Postdoctoral Associate with Professor Timothy F. Jamison
Ph.D. Princeton University, 2013
"Palladium(0)-Catalyzed Aliphatic Carbon–Fluorine Bond Formation: Methods and Mechanism"
with Abigail G. Doyle
A.B. Harvard University, 2005 (Chemistry)

Current Research:
Cascade reactions for the synthesis of ladder polyether natural products

  • Seo, H.; Katcher, M. H.; Jamison, T. F. “Photoredox Activation of Carbon Dioxide for Amino Acid Synthesis in Continuous Flow,” Nat. Chem. 2016, ASAP. DOI: 10.1038/nchem.2690.
  • Siu, T.; Kumarasinghe, S. E.; Altman, M. D.; Katcher, M.; Northrup, A.; White, C.; Rosenstein, C.; Mathur, A.; Xu, L.; Chan, G.; Bachman, E.; Bouthillette, M.; Dinsmore, C. J.; Marshall, C. G.; Young, J. R. “The discovery of reverse tricyclic pyridone JAK2 inhibitors. Part 2: Lead optimization.” Bioorg. Med. Chem. Lett.2014, 24, 1466–1471.

  • Katcher, M. H.; Norrby, P.-O.; Doyle, A. G. “Mechanistic Investigations of Palladium-Catalyzed Allylic Fluorination.” Organometallics, 2014, 33, 2121-2133.

  • Northrup, A. B.; Katcher, M. H.; Altman, M. D.; Chenard, C.; Daniels, M. J.; Deshmukh, S. V.; Falcone, D.; Guerin, D. J.; Hatch, H.; Li, C.; Lu, W.; Lutterbach, B.; Patel, S. B.; Reilly, J. F.; Reutershan, M.; Rickert, K. W.; Rosenstein, C.; Soisson, S. M.; Szewczak, A. A.; Walker, D.; Wilson, K. Young, J. Pan, B.-S.; Dinsmore, C. J. “Discovery of 1-[3-(1-Methyl-1H-pyrazol-4-yl)-5-oxo- 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron Dual Kinase Inhibitor with Preferential Affinity for the Activated State of c-Met.” J. Med. Chem.201356, 2294–2310.

  • Braun, M.-G.; Katcher, M. H.; Doyle, A. G. “Carbofluorination via a Palladium-Catalyzed Cascade Reaction.” Chem. Sci., 20134, 1216–1220.)

  • Katcher, M. H.; Sha, A.; Doyle, A. G. “Palladium-Catalyzed Regio- and Enantioselective Fluorination of Acyclic Allylic Halides.” J. Am. Chem. Soc.2011133, 15902–15905.

  • Katcher, M. H.; Doyle, A. G. “Palladium-Catalyzed Asymmetric Synthesis of Allylic Fluorides.” J. Am. Chem. Soc.2010132, 17402–17404.

  • Grimm, J. B.; Katcher, M. H.; Witter, D. J.; Northrup, A. B.  “A New Strategy for the Synthesis of Benzylic Sulfonamides: Palladium-Catalyzed Arylation and Sulfonamide Metathesis.” J. Org. Chem.200772, 8135–8138.

    katcher at mit dot edu