The Jamison Research Group

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Zhi He

Education:
  Massachusetts Institute of Technology, 2012 - present
Postdoctoral Associate with Professor Timothy F. Jamison
Ph.D. University of Toronto, Canada, 2012
“Synthetic Application of Amphoteric Aziridine Aldehydes and α-Boryl Aldehydes”
with Professor Andrei K. Yudin
M.Sc. University of Toronto, Canada, 2006
“Palladium(II)-Catalyzed Oxidative Activation of Arylcyclopropanes”
with Professor Andrei K. Yudin
B.Sc. Peking University, China, 2003
“Application of Electroorganic Chemistry in the Synthesis of Furanone and 2,5-Diaminotoluene Sulfate”
with Professor Shrong-Shi Lin

Current Research:
    Continuous-Flow Synthesis (MIT-Novartis Collaboration)

Publications:
  • He, Z.; Bae, M.; Wu, J.; Jamison, T. F. “Synthesis of Highly Functionalized Polycyclic Quinoxaline Derivatives Using Visible-Light Photoredox Catalysis” Angew. Chem. Int. Ed. 201453, early view (DOI: 10.1002/anie.201408522).
  • He, Z.; Zajdlik, A.; Yudin, A. K. “α-Borylcarbonyl Compounds: from Transient Intermediates to Robust Building Blocks” Dalton Trans. 201443, 11434−11451.
  • Wu, J.; Yang, X.; He, Z.; Mao, X.; Hatton, T.A.; Jamsion, T.F. "Continuous Flow Synthesis of Ketones from Carbon Dioxide and Organolithium or Grignard Reagents" Angew. Chem. Int. Ed. 2014, 53, 8416-8420.
  • He, Z.; Jamison, T. F. “Continuous-Flow Synthesis of Functionalized Phenols via Aerobic Oxidation of Grignard Reagents” Angew. Chem. Int. Ed., 2014, 53, 3353-3357.
  • He, Z.; Yudin, A. K. “Air- and Moisture-stable Amphoteric Molecules: Enabling Reagents in Synthesis” Acc. Chem. Res. 2014, 47, 1029-1040.
  • Zajdlik, A.; He, Z.; St Denis, J. D.; Yudin, A. K. “Efficient Preparation of a-Aminoboronic Acid Derivatives via Boroalkyl Group Migration” Synthesis 2014, 46, 445−454.
  • Chen, G.; He, Z.; Yudin, A. K. “Synthesis of Functionalized 1-Azabicyclo[3.1.0]hexanes: Studies towards Ficellomycin and Its Analogs” Heterocycles 2014, 88, 1299−1310.
  • Liew, S.; He, Z.; Yudin, A. K. “Stereocontrolled Synthesis of Vicinal Diamine Building Blocks from Aziridine Aldehyde Dimers” J. Org. Chem. 2013, 78, 11637−11645.
  • He, Z.; Dobrovolsky, D.; Trinchera, P.; Yudin, A. K. “Synthesis of Multisubstituted Pyridines” Org. Lett. 2013, 15,334−337.
  • He, Z.; Trinchera, P.; Adachi, S.; St. Denis, J. D.; Yudin, A. K. “Oxidative gem-Functionalization of Organoboron Compounds” Angew. Chem. Int. Ed. 2012, 51, 11092−11096.
  • St. Denis, J. D.; He, Z.; Yudin, A. K. “Chemoselective Palladium-Catalyzed α-Allylation of α-Boryl Aldehydes” Org. Biomol. Chem. 2012, 10, 7900−7902.
  • He, Z.; Zajdlik, A.; St. Denis, J. D.; Assem, N.; Yudin, A. K. “Boroalkyl Group Migration Provides a Versatile Entry into α-Aminoboronic Acid Derivatives” J. Am. Chem. Soc. 2012, 134, 9926−9929.
  • Assem, N.; Hili, R.; He, Z.; Kasahara, T.; Inman, B.; Decker, S.; Yudin, A. K. “Control of Carbonyl Reactivity Using Reversible Covalent Interactions” J. Org. Chem. 2012, 77, 5613−5623.
  • He, Z.; Yudin, A. K. “Amphoteric α-Boryl Aldehydes” J. Am. Chem. Soc. 2011, 133, 13770−13773.
  • Cheung, L. L. W.; He, Z., Decker, S. M.; Yudin, A. K. “Skeletal Fusion of Small Heterocycles with Amphoteric Molecules" Angew. Chem. Int. Ed. 2011, 50, 11798–11802.
  • He, Z.; Yudin, A. K. “A Versatile Synthetic Platform Based on Strained Propargyl Amines” Angew. Chem. Int. Ed. 2010, 49, 1607−1610.
  • He, Z.; Yudin, A. K. "Palladium-Catalyzed Oxidative Activation of Arylcyclopropanes" Org. Lett. 2006, 8, 5829−5832.

Contact:
    zhihe at mit dot edu