Research in the Jamison Group

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Continuous-Flow Chemistry

The Jamison Research Group seeks to develop chemical methods under continuous flow conditions which:
  • Enable reactions that would otherwise be difficult or improbable to achieve under batch conditions
  • Streamline multistep processes
  • Improve reaction efficiency (yield/selectivity)
  • Decrease safety risks
  • Improve the environmental profiles of reactions

New Continuous Flow Methods.
We are focused on developing new reactions that benefit from the many attibutes of flow. This includes reactions which are (1) fast and/or exothermic; (2) mixing- or transport-dependent (e.g. gas-liquid); (3) pathlength dependent (e.g. photochemical, electrochemical); (4) involve unstable or hazardous intermediates; and (5) are “slow” under typical conditions. Examples of our research included the following:

Synthesis of amino acids and β-hydrocarboxylated styrenes via photoredox activation of CO2

J. Am. Chem. Soc., 2017, 139, 13969–13972; Nat. Chem. 2017, 9, 453-456.

Synthesis of fluorinated pyrazoles and pyrazolines

Angew. Chem. Int. Ed. 2017, 57, 8823-8827

Synthesis of sequence-defined polymers via Flow-IEG (iterative exponential growth)

Nat. Chem. 2015, 7, 810-815; Proc. Natl. Acad. Sci. USA, 2015, 112, 10617-10622

Targeted Synthesis in Flow.
Continuous flow enables highly efficient synthesis through the telescoping of multistep and multicomponent reactions. Along with developing streamlined syntheses of active pharmaceutical ingredients and fine chemicals, our group is involved in collaborative efforts aimed at the development of automated, stand-alone, continuous flow platforms capable of synthesis, purification and formulation processes.