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Brian Saxton Underwood |
Education:
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Massachusetts Institute of Technology, 2005 - present
Ph.D. candidate with Prof. Timothy F. Jamison |
| B.Sc. |
California Institute of Technology, 2005
with Prof. Brian Stoltz
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Current research:
As part of ongoing research in the lab involving endo-epoxide closures using a variety of lewis-acid/basic conditions, this project involves the total synthesis of Armatol A using a ring-closing cascade reaction.
Isolated in 2000 from Chondria armata the active agents in the plant have antiviral, antibacterial, and antifungal activities, which suggest active agents could be unusual lipophilic metabolites. |
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Publications:
- Lainé, D. I.; McCleland, B.; Thomas, S.; Neipp, C.; Underwood, B.; Dufour, J.; Widdowson, K. L.; Palovich, M. R.; Blaney, F. E.; Foley, J. J.; Webb, E. F.; Luttmann, M. A.; Burman, M.; Belmonte, K.; Salmon, M. “Discovery of Novel 1-Azoniabicyclo[2.2.2]octane Muscarinic Acetylcholine Receptor Antagonists,” J. Med. Chem. 2009, 52, ASAP
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