Chemformation


The Weekly Newsletter of the MIT Chemistry Department

Volume 15, Number 15

Friday, April 30, 1999

Chemformation is published by the Office of the Department Chairman. Please convey items of interest (or mailing list changes) to Linda Earle, Room 18-390, Department of Chemistry, MIT, Cambridge, MA 02139, 617/253-4080; 617/258-7500 (fax) or e-mail to lkn@mit.edu. Back issues of Chemformation can be accessed via the Chemistry Department Website.

Visit the Chemistry Department Website at http://web.mit.edu/chemistry/www/


Seminar Calendar

Tuesday, May 4, 1999
4:00 in Room 2-105
Seminar in Physical Chemistry
Refreshments @ 3:30 in 6-233
Professor Grzegorz Szamel
Colorado State University
"Theory for Single-Molecule Dynamics
in Liquids"
Tuesday, May 4, 1999
9:30 a.m. in Room 6-120
Chemistry 5.561
Chemistry in Industry Lecture Series
Dr. Jeffrey H. Epstein-Toney
Merck Research Laboratories
"Merck¼s Armament Against Antibiotic
Resistance: A Chemical Biology Approach"
Thursday, May 6, 1999
9:30 a.m. in Room 6-120
Chemistry 5.561
Chemistry in Industry Lecture Series
Dr. Steven A. King
Abbott Laboratories
"Diastereo-and Enantioselective Synthesis
of Highly Substituted Pyrrolidines Leading
to Potent Endothelin Antagonists"
Thursday, May 6, 1999
4:00 p.m. in Room 6-120
Seminar in Biological Chemistry
Refreshments @ 3:45 p.m.
Dr. Elizabeth Theil
Children¼s Hospital, Oakland Research Institute
"Ferritin, At the Crossroads of Iron and
Oxygen Biology"
Friday, May 7, 1999
2:00 p.m. in Room 6-120
A Symposium on "Recent Advances in
Organic Synthesis Methodologies"
(see announcement in this issue)
Speakers:
Professor Mark Snapper, Boston College
Professor Rick Danheiser, MIT
Professor Stephen F. Martin, University of Texas
Tuesday, May 11, 1999
9:30 a.m. in Room 6-120
Chemistry 5.561
Chemistry in Industry Lecture Series
Dr. Kevin Chapman
Merck Research Laboratories
"Combinatorial Approaches to the
Somatostatin Family of Receptors"
Wednesday, May 12, 1999
4:00 p.m. in Room 6-120
Seminar in Inorganic Chemistry
Refreshments @ 3:30 p.m.
Professor James K. McCuster
University of California at Berkeley
"Electronic Structure Effects on the
Photo-Induced Dynamics of Transition
Metal Complexes",/TD>
Friday, May 14, 1999
1:00 p.m. in Room 66-100
Graduate Research Symposium on
Organic and Bioorganic Chemistry
Justin Miller, Kemp Group
Dana Buske, Masamune Group
Greg Dudley, Danheiser Group
Ron Castellano, Rebek Group
George Greco, Schrock Group
Kevin Shea, Danheiser Group
Marcus Hansen, Buchwald Group
JosÈ Rivera-Ortiz, Rebek Group
Dave Simone, Swager Group


Massachusetts Institute of Technology
Department of Chemistry

Chemistry 5.561
"Chemistry in Industry" Lecture Series


All lectures 9:30 AM in Room 6-120

May 4 Dr. Jeffrey H. Epstein-Toney
Research Fellow in Endocrinology & Chemical Biology
Merck Research Laboratories

"Merck's Armament Against Antibiotic Resistance:
A Chemical Biology Approach "
May 6 Dr. Steven A. King
Project Leader, Department of Process Research
Abbott Laboratories

"Diastereo- and Enantioselective Synthesis of Highly
Substituted Pyrrolidines Leading to Potent Endothelin Antagonists"
May 11 Dr. Kevin Chapman
Senior Director, Medicinal Chemistry
Merck Research Laboratories

"Combinatorial Approaches to the Somatostatin
Family of Receptors"


Massachusetts Institute of Technology
Department of Chemistry

A SYMPOSIUM ON

RECENT ADVANCES IN
ORGANIC SYNTHESIS

Friday, May 7, 1999
2:00 PM Room 6-120

Marc L. Snapper
Boston College
"New Strategies for the Synthesis
of Biological Probe Reagents"
Rick L. Danheiser
Massachusetts Institute of Technology
"Studies Directed Toward the
Total Synthesis of Glycinoeclepin A"
Stephen F. Martin
University of Texas, Austin
"Recent Advances in the Synthesis of
Heterocyclic Natural Products"
Sponsored by Organic Syntheses, Inc.
For information, contact Professor Rick Danheiser


Massachusetts Institute of Technology
Department of Chemistry

Graduate Research Symposium in Organic and Bioorganic Chemistry

Friday, May 14, 1999
1:00 PM Room 66-110

Justin Miller
Kemp Group
"Efforts Towards the Total Synthesis of
CP-263,114, A Highly Oxygenated
Natural Product"
Dana Buske
Masamune Group
"The Boron-Mediated Aldol Reaction of Carboxylic Esters"
Greg Dudley
Danheiser Group
"Synthetic Approaches to Ascochlorin
and Related Compounds"
Ron Castellano
Rebek Group
"Reversibly-Formed Polymeric Capsules Based On Calixarenes"
George Greco
Schrock Group
"Dinitrogen Activation by Molybdenum and
Tungsten Complexes That Contain Aryl-
Substituted Triamidoamine Ligands"
* * * * Refreshments * * * *
Kevin Shea
Danheiser Group
"Synthesis and Properties of 9-Alkyl and -Aryl
Cyclopenta[a]phenalene Derivatives"
Marcus Hansen
Buchwald Group
"Recent Progress in Asymmetric Titanium-Catalyzed
Imine Reduction"
JosÈ Rivera-Ortiz
Rebek Group
"Chiral Spaces: Dissymmetric Capsules
Through Self-Assembly"
Dave Simone
Swager Group
"Synthesis, Binding Properties, and Electrochemical Studies of Crown Ethers, [2]-
Catenanes, and [2]-Rotaxanes. Progress Towards Photoconducting Poly([2]-
Catenanes) and Poly([n]-Rotaxanes)"


Message from the Chemistry Librarian Erja Kajosalo

The following new chemical electronic resources are now available for MIT community from the MIT Libraries:

* SciFinder Scholar allows access to 'Chemical Abstracts' including the CAS Registry file with over 19 million substances, and CAPlus file which is the most comprehensive database of all chemical literature including patents and conference proceedings. We have four (4) simultaneous users with after 5pm plus weekend access. For more information, go to http://libraries.mit.edu/science/Subjects/Chemistry/scifinder.html

* We have now electronic access to some Wiley journals including 'Angewandte Chemie International Edition, Chemistry - A European Journal, European Journal of Inorganic Chemistry, European Journal of Organic Chemistry, Helvetica Chimica Acta, Heteroatom Chemistry and Journal of Materials Chemistry'. You must register to access these journals. For more info go to http://libraries.mit.edu/science/Subjects/Chemistry/ejournal.html

* The latest version of Beilstein CrossFire commander software (4.0) is now available. For more info go to http://libraries.mit.edu/science/Subjects/Chemistry/beilstein.html

* the latest new book list is available at http://libraries.mit.edu/science/Subjects/Chemistry/news.html

If you have any questions, please contact the chemistry librarian Erja Kajosalo (kajosalo@mit.edu or x3-9795).


Minority & Women Doctoral Directory

The 10th Edition of the Minority & Women Doctoral Directory will be published in Fall 1999. If you are interested in being included, please pick up a Release Form from the Department's Headquarters Office (18-390) or the Chemistry Education Office (2-204). Form can also be downloaded from www.mwdd.com.

Complete the Form and submit it with a rÈsumÈ to M.-T. Kouo or Kitty Valleli in 18-390. Listing is free for the first listing. Updates are available to students and graduates listed in the prior editions for $20. Deadline: 8/31/99.


Get Organized!

Call Ed Udas at 253-4505 or stop by room 4-065 if students, faculty, or staff need help in organizing their MIT space.


Glass Blowing Services

Bob DiGiacomo will be coming in on Wednesdays or Thursdays to pick up any glass blowing work that you may have available. Please bring any work to room 4-064 or call Ed Udas or John Annese at 3-4505. Bob will do the work on a first-come, first-served basis.


Positions Open at Organix

Organix Company located in Woburn, MA has positions open for motivated and experience MS and Ph.D. synthetic organic chemists excited by chemistry and eager to work in a moderin, well-equipped and dyanmic company in the Boston area. Scientists positions available for MS qualified individuals. They would like you to participate in their research in a wide variety of synthetic areas. Industrial experience preferred. Postdoctoral psotions available at the forefront of discovery of new CNS active compounds. Experience in multistep organic synthesis is preferred. Organix offers a vibrant and stimulating work environment and competitive salary for strongly motivated individuals. They provide an excellent salary and comprehensive benefits package including health, dental and eye insurance. 401K and a profit sharing plan and year end bonus. Applications should include a resume, a description of experience, including reaction scheme summaries and three references. Organix hires without regard to race, color, religion, sex, age or national origin. Organix Inc. 240 Salem Street, Woburn, MA 01801. Telephone is (781) 932-4142 and fax is (781) 933-6695.


Postdoctoral Positions

Sandia National Laboratories in Livermore, California. The Combustion Research Facility is seeking a recent PhD scientist or engineer interested in MOLECULAR SENSOR DEVELOPMENT and applications. The successful candidate will join a team that is actively developing and applying optical spectroscopic techniques for real-time sensors of interest to the Departments of Energy, Defense, and U.S. industry. Current work has been based on tunable-diode-laser ABSORPTION SPECTROSCOPY in the mid- and near-infrared regions, and new laser-based mid-infrared sources are being developed in conjunction with other teams at Sandia. Many of the sensor applications are in highly particle-laden gas streams at high temperature. An example of current activities is the application of time-resolved measurements of gas-phase concentrations and temperatures for real-time control of processes in both basic oxygen and electric arc steelmaking. In addition to commercial steelmaking, we are currently conducting experiments in demilitarization of conventional munitions, large-scale pool fires, and the assessment of long-term aging of organic materials in weapons components. The successful candidate will be exceptionally strong technically and be a creative problem-solver. Candidates should have a Ph.D. in either the physical sciences or engingineer and have demonstrated experimental and modeling research experience with aspects of molecular spectroscopy, optics, lasers, combustion diagnostics, electronics, computer simulation, data analysis and methods for process control. Experience with fiber-optically coupled lasers is also advantageous.Laboratory and communications skills must be excellent, and the ability to work independently or in a team environment is a must. Travel for field experiments is required for this position. Please send a resume, with names of references, statement of research expertise, and copies of college transcripts to: Sandia National Laboratories, Anna Isham, MS 9111, HR Dept-CA0022, Job Code DRH-1250, P.O Box 969, Livermore, CA 94551-0969. US citizenship is required. Sandia National Laboratories is an Equal Opportunity / Affirmative Action employer. For more information, please contact: Sarah Allendorf, Principal Member of the Technical Staff, Sandia National Laboratories, MS 9052, P.O. Box 969, Livermore, CA 94551-0969, (925)294-3379. SWALLEN@SANDIA.GOV

The Gas Phase Chemical Dynamics Program at Argonne National Laboratory has an opening for a post doctoral appointment working with R. Glen Macdonald. The research involves the use of high resolution time-resolved near infrared and infrared absorption spectroscopy to study the spectroscopy, dynamics and kinetics of radicals of interest to combustion and atmospheric chemistry. The main thrust of the program over the next few years will be to study the dynamics and kinetics of atom + radical and radical + radical processes; however, other studies are possible, depending on the qualifications and interests of the successful candidate. Several recent articles will give potential candidates an idea of the variety of problems that can be tackled with this apparatus; a) Infrared Spectroscopy, J. Mol. Spectroscopy 186, 349 (1997). b) Chemical Kinetics, J. Phys. Chem. 102, 4585 (1998), and c) Chemical Dynamics, J. Chem. Phys. 109, 4224 (1998). The successful candidate should be planning to graduate soon or be a recent graduate from a Chemical Dynamics or Kinetics Program(within the last 3 years), and have experience in laser spectroscopy, vacuum techniques, and computer data acquisition. A background in rovibrational spectroscopy of polyatomic molecules would be a desirable asset. An application will require a CV and three letters of recommendation. For further information, interested candidates should contact Glen Macdonald. The Gas Phase Chemical Dynamics Program at Argonne consists of ten permanent staff members, five theoreticians and five experimentalists. It offers an unique opportunity for the close interaction between theory and experiment. Argonne is a National Laboratory operated by the University of Chicago for the Department of Energy, and is an equal opportunity employer. The laboratory is located about 25 miles west of Chicago, Illinois, USA. R. Glen Macdonald: (630) 252-7742:Fax.(630) 252-4470 Argonne National Laboratory, Chemistry Division 9700 South Cass Ave. Argonne, IL 60439. Email. macdonald@anlchm.chm.anl.gov

Postdoctoral Research Associate Biological Inorganic Chemistry R & A1A £15,735-£23,651 pa (ref: R9042/NT) Applications are invited for a BBSRC funded 3-year postdoctoral position in the area of biological inorganic chemistry. The project will explore the mechanistic and redox properties in the haem enzyme ascorbate peroxidase, and will use protein engineering, kinetic, electrochemical and spectroscopic techniques. Candidates should have a PhD in chemistry, biochemistry or related discipline and experience in kinetic/mechanistic work would be an advantage. Formal applications should be made to the Personnel Office, University of Leicester, University Road, Leicester, LE1 7RH, please quote reference number (R9042/NT). Informal enquiries may be made to Dr. Emma (nee Lloyd) Raven on 0116-252-2099 or email emma.raven@le.ac.uk. Closing date: 28th May 1999.

Postdoctoral at the University of Kentucky: involves the study of metal clusters and complexes using ZEKE photoionization, TOF-MS, and ab initio methods. The position is available from July 1, 1999 and is initially for one year with possibility of extension. Experience in laser spectroscopy and / or electronic structure calculations is required. Please send a complete CV and names of two references to Dr. Dong-Sheng Yang, Department of Chemistry, University of Kentucky, Lexington, KY 40506-0055. FAX: 606-323-1069. E-mail: dyang0@pop.uky.edu. The University of Kentucky is an EO/AA employer.

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